腹腔神经丛阻滞

摘要： 目的:探讨腹腔神经丛阻滞对大鼠肝部分切除术后应激反应及免疫炎性的影响,并阐明其作用机制.方法:取40只大鼠,随机选取10只作为正常组,10只作为阻滞剂对照剂组,20只制备大鼠肝部分切除术模型.取造模成功的16只大鼠,随机分为模型组和模型+阻滞剂组,每组8只.模型+阻滞剂组大鼠于术毕关腹前给予腹腔神经丛双侧注射0.5％利多卡因,阻滞剂对照组大鼠不制备模型,给予腹腔神经丛双侧注射0.5％利多卡因,正常组与模型组大鼠给予腹腔神经丛双侧注射等量生理盐水.给药12 h后,酶联免疫吸附试验(ELISA)法检测各组大鼠血清中皮质酮(CORT)、促肾上腺皮质激素(ACTH)、去甲肾上腺素(NE)、肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)和白细胞介素6(IL-6)水平,实时荧光定量聚合酶链式反应(RT-qPCR)和Western blotting法检测各组大鼠外周血单个核细胞中糖皮质激素受体(GR)、Toll样受体4(TLR4)mRNA和蛋白表达水平.结果:与正常组和阻滞剂对照组比较,模型组和模型+阻滞剂组大鼠血清中CORT、ACTH和NE水平升高(P0.05).结论:腹腔神经丛阻滞能减轻肝部分切除术后大鼠的应激反应及免疫炎性反应,其机制可能与上调GR蛋白表达和下调TLR4蛋白表达有关.

摘要： Objective To evaluate the efficacy of endoscopic ultrasonography-guided celiac plexus radiation with iodine-125 (125I) seeds and celiac plexus neurolysis with absolute ethanol for pain relief secondary to advanced pancreatic cancer.Methods A retrospective analysis of 43 patients of advanced pancreatic cancer with moderate to severe abdominal pain in the Department of Gastroenterology,Shanghai Changhai Hospital from January 2017 to April 2018 was performed.20 patients underwent EUS-guided celiac plexus neurolysis (CPN),and 23 patients underwent EUS-guided celiac plexus radiation (CPR) with the implantation of 125I seeds around the celiac ganglia.The postoperative VAS score of abdominal pain,mean analgesic (MS Contin [morphine sulfate]) consumption and complications were compared between the two groups.Results There were no statistically significant differences between the two groups in the sex ratio (male/female,10/10 vs 14/9),average age [(64 ± 11) vs (64 ± 12)],lesion location (head/tail,7/13 vs 8/15] and TNM stage (Ⅲ/Ⅳ,9/11 vs 7/16),and the two groups were comparable.Compared with preoperative ones,the VAS score (3.0 points vs 5.5 points) and morphine dosage (30 mg vs 52.5 mg) were significantly lower in the CPN group one week after operation.In the CPR group,the VAS score (5.0 points vs 6.0 points) and morphine dosage (50 mg vs 55 mg) at 2 weeks after the operation were lower than those before the operation;the VAS scores of 4,8 and 12 weeks after the operation decreased to 3.0 points,and the dosage of morphine decreased to 30 mg,25 mg and 30 mg,respectively.The differences were statistically significant (P＜0.0001).Compared with the CPR group,at 2 weeks postoperatively the CPN group demonstrated a significantly higher decrease of VAS score (3.0 points vs 2.0 points),degree of morphine reduction (30 mg vs 10 mg) and rate of partial pain relief (70.0％ vs 4.3％).However,from 4 to 12 weeks postoperatively,the decrease in VAS score,the decrease in the dosage of MS Contin and the rate of partial pain relief in the CPR group were all significantly higher than those in the CPN group (P ＜ 0.05).There was no complete relief of pain in the two groups.No procedure-related deaths or serious complications were observed and only mild gastrointestinal adverse reactions occurred.Conclusions Two methods can both relieve abdominal pain in patients with advanced pancreatic cancer safely and effectively.CPR takes effect late but has advantages of good extent and long duration of pain relief.%目的 评估内镜超声(EUS)引导下125I粒子腹腔神经丛放射术和无水乙醇腹腔神经丛阻滞术治疗晚期胰腺癌腹痛的疗效.方法 回顾性分析第二军医大学长海医院消化内科2017年1月至2018年4月间收治的43例伴有中重度腹痛的晚期胰腺癌患者的临床资料,其中20例接受EUS引导下腹腔神经丛阻滞术(CPN),23例接受EUS引导下腹腔神经丛放射术(CPR),即在腹腔神经丛植入125I粒子.比较CPN组与CPR组患者术后腹痛VAS评分、硫酸吗啡控释片用量及并发症发生情况.结果 CPN组与CPR组患者的性别比(男/女,10/10比14/9)、平均年龄[(64±11)岁比(64±12)岁]、病灶部位(头部/体尾部,7/13比8/15)、TNM分期(Ⅲ/Ⅳ,9/11比7/16)的差异均无统计学意义,具有可比性.与术前相比,术后1周CPN组患者VAS评分(3.0分比5.5分)及吗啡用量(30.0 mg比52.5 mg)显著降低;术后2周CPR组VAS评分(5.0分比6.0分)及吗啡用量(50.0 mg比55.0 mg)均低于术前,且术后4、8、12周VAS评分均为3.0分,吗啡用量分别降至30.0、25.0、30.0 mg,与术前比较差异均具有统计学意义(P值均＜0.0001).与CPR组比较,术后2周CPN组患者VAS评分下降程度(3.0分比2.0分)、吗啡用量减少程度(30.0 mg比10.0 mg)及腹痛部分缓解率(70.0％比4.3％)均更高(P值分别为0.01、0.005、＜0.001);但术后4、8、12周CPR组患者较术前VAS评分下降程度、吗啡用量减少程度及腹痛部分缓解率均显著高于CPN组(P值均＜0.05).CPN组与CPR组患者无1例疼痛完全缓解,未观察到严重并发症的发生,仅有轻度消化道不良反应.结论 CPN和CPR均能安全、有效地缓解晚期胰腺癌患者的腹痛.CPR起效时间晚,但疼痛缓解程度及持续时间更具优势.

摘要： To investigate the effects of neurolytic celiac plexus block (NCPB)on blood glucose and insulin receptor substrate in GK (Goto-Kakizaki)rats,the GK rats were used to establish a non-insulin dependent diabetes mellitus (NIDDM)model. 5 GK rats before NCPB were randomly selected to be subjected to the oral glucose tolerance test (OGTT)and the liver tissue was excised. The remaining 20 GK rats were randomly divided into two groups:rats in the NCPB group were treated with 0. 5% lidocaine (1mL/1 time/day)for 28 consecutive days,while the control group received the same procedure with physiological saline injected instead of 0. 5%lidocaine. The OGTT were performed after 14 and 28 days. Western blot assay was used to analyze the expression of insulin receptor substrate 1 (IRS-1),IRS-2 and phosphorylation of IRS-1 in the liver tissue. After 14 and 28 days of treatment with NCPB,the con-centration of blood glucose in the NCPB group was significantly lower than before NCPB (P<0. 05 or P<0. 05)and the control group (P<0. 01)at 0,60 and 120 min of the OGTT,while the levels of serum insulin exhibited no statistical difference between the control group and the NCPB group. The IRS-1 and IRS-2 expression levels of liver tissue in the NCPB group were significantly higher than con-trol group at the corresponding time points (P<0. 01),which significantly increased compared to before NCPB (P<0. 01). The phosphorylation level of Ser 307 of IRS-1 was significantly lower in the NCPB group than the control group (P<0. 01)at the corre-sponding time points,which declined significantly (P<0. 01)in the NCPB group,while were significantly increased (P<0. 05)in the control group compared with before NCPB. The NCPB treatment can decrease the fasting blood glucose level as well as reduce the degree of impaired glucose tolerance in GK rats. The mechanism may be related to increased protein expression and inhibition of the serine phosphorylation.%观察NCPB对GK(Goto-Kakizaki,GK)大鼠血糖及胰岛素受体底物的影响.构建25只非胰岛素依赖糖尿病(NIDDM)的雄性GK大鼠,随机抽取5只GK大鼠,以NCPB前表示,先进行口服葡萄糖耐受试验(OGTT),然后处死采取肝组织.其余20只GK大鼠随机分为对照组和NCPB组,每组10只.NCPB组给予双侧质量分数0.5%利多卡因进行NCPB,1 mL/侧,每天1次,而对照组以质量分数0.9%生理盐水替换.分别在14 d和28 d后取对照组和NCPB组各5只GK大鼠进行OGTT实验,通过Western Blot检测对照组和NCPB组肝组织中的胰岛素受体底物-1(IRS-1)、IRS-2表达以及IRS-1磷酸化情况.结果表明:NCPB组在14 d和28 d NCPB处理后,在0、60和120 min时的血糖均显著低于NCPB前(P<0.05或P<0.01)和对照组(P<0.01),而血清胰岛素水平与NCPB前和对照组相差不显著;在14、28 d NCPB后NCPB组肝组织IRS-1和IRS-2蛋白表达水平与NCPB前相比均显著增加(P<0.01),在相应时间点并显著高于对照组(P<0.01);而对照组的肝组织IRS-1丝氨酸307残基的磷酸化水平在14、28 d NCPB后与NCPB前均有所上调(P<0.05),NCPB组在相应时间点丝氨酸307残基的磷酸化程度均较NCPB前显著下降(P<0.01),且均显著低于对照组(P<0.01).NCPB可降低GK大鼠的空腹血糖,减轻GK大鼠糖耐量受损的程度,其机制可能与NCPB提高胰岛素受体底物的蛋白表达和抑制其丝氨酸磷酸化有关.

摘要： Pancreatic cancer is a malignant digestive system tumor.The incidence of pancreatic cancer is rising,the prognosis is very poor,the mortality rate is extremely high (almost 100％),and the 5-year survival rate is less than 5％.One of the main symptoms of this tumor is pain and mostly neuropathic origin,which significantly decreases the quality of life and the impacts on patient's functional activity.The most common pain treatment for pancreatic cancer is drug analgesia therapy,which is based on the WHO analgesic ladder rule.However,it is not always effective,and many side effects reduce the quality of life of patients.Invasive treatment of pain in pancreatic cancer mainly includes neurolytic celiac plexus block and splanchnicectomy,which can significantly reduce the level of pain and help to improve the quality of life.Invasive remedies should not be applied at the final stage and should be considered in the early stages of the disease (such as the first or second step of the WHO analgesic ladder).This paper comprehensively analyzes the current clinical treatment of pancreatic cancer pain and evaluates its effectiveness,and hopes to provide more information on the treatment of pain in patients with pancreatic cancer.%胰腺癌是一种恶性程度较高的消化系统肿瘤,发病率持续上升,预后极差,5年生存率低于5％,死亡率极高,几乎达100％.胰腺癌主要症状之一是疼痛,大部分属于神经源性起源,显著降低患者的生活质量并影响功能活动.胰腺癌最常见的疼痛治疗是药物镇痛治疗,这是基于WHO镇痛阶梯规则.但是它并不总奏效,且许多不良反应降低了患者生活质量.胰腺疼痛的侵入性治疗主要包括腹腔神经丛阻滞和内脏神经切断术,可显著降低疼痛水平,有助于提高生活质量.微创手术不应在最后阶段使用,应考虑在疾病早期阶段(如WHO镇痛阶梯治疗的第一或第二步).本文综合分析了目前临床上胰腺癌疼痛治疗方法,评估其有效性,希望获取更多对治疗胰腺癌疼痛有帮助的信息.

摘要： 癌性腹痛是一种腹部晚期恶性肿瘤所致的剧烈疼痛,由于其无法从根本上有效治疗,所以对于患者及家属而言是很严重的问题.腹腔神经节阻滞是一种以治疗与诊断腹部脏器疼痛为目的的介入技术,而腹腔神经节接受肝脏、胰腺、脾脏、网膜、直到横结肠的消化道、肾上腺以及肾脏的病理状态下的感觉传入.腹腔神经节阻滞已经运用在肝脏、胰腺、肾脏等脏器的炎症与癌症引起的难治性剧烈疼痛的治疗,理论上它能降低患者对阿片类药物的依赖并提高药物止痛的效果.过去,该神经节的阻滞都是通过触诊骨性标志,辨认局部软组织进行,而现在,各种各样的显像技术被运用在介入治疗疼痛上.X射线透视、计算机断层扫描(CT)、超声内镜可被用于帮助医生们进行腹腔神经节(丛)阻滞.辅助技术的选择依赖于医生们的专业特色,比如胃肠病学者会选择超声内镜技术,内科医生选择介入治疗,影像学医生选择CT引导.该文章是为了描述各种辅助技术的方法及适用范围,以期为难治性剧烈腹痛的患者更好的进行腹腔神经节的阻滞治疗.

摘要： 目的:研究腹腔神经丛阻滞对大鼠肝部分切除术后残肝炎症反应的影响效果.方法:对30只雄性大鼠行肝部分切除术,然后将其随机分为两组各15例,观察组在术后12h于双侧给予利多卡因(0.5％)行经皮腹腔神经丛阻滞,对照组以生理盐水(0.9％)替换,对比两组肝功能水平与炎症因子表达量.结果:观察组AST(天门冬氨酸转氨酶)、ALT(丙氨酸转氨酶)含量均明显低于对照组,P<0.05;观察组炎症因子IL-β(白细胞介素-β)、TNF-α(肿瘤坏死因子)表达量均明显低于对照组,P<0.05.结论:对于行肝部分切除术大鼠而言,选择腹腔神经丛阻滞可以显著地提升肝功能水平以减少炎症因子,值得推广应用.

摘要： Objective To investigate the effects of neurolytic celiac plexus block(NCPB) on stress response during the early stage of partial hepatectomy(PH) postoperation in rats.Methods Thirty healthy SPF-grade male Sprague-Dawley rats were randomly divided into control group and NCPB group,and then were constructed the 70％ PH model.NCPB group received NCPB with 0.5 ％ lidocaine before closing abdominal,and control group received the same procedures,but 0.9％ physiological saline was injected instead of 0.5 ％ lidocaine.The serum concentration of CRP,GC,ACTH,NA and AD,and the levels of serum TNF-α and IL-1β were determined at 6 hours,12 hours and 24 hours after PH.The western blot assay was performed to examine the expression of GR in the peripheral blood mononuclear cells (PBMCs).Results The obvious stress response was produced within 24 hours after PH in rats,postoperative serum CRP,GC,ACTH,NA and AD concentrations increased in the different extent,but the NCPB group were significantly lower than those in the control group in the corresponding time point (P ＜0.01 or P ＜0.05).The expression levels of GR in PBMCs in the control group were significantly decreased after PH,and markedly lower than those in the NCPB group in the corresponding time point(P ＜ 0.01).The serum TNF-o and IL-1β levels were gradually increased in the control group and NCPB group within 24 hours after PH.But at the respective time points,the levels in the NCPB group were significantly lower than those in control group(P ＜ 0.01 or P ＜ 0.05).Conclusion Intraoperation NCPB can effectively inhibit postoperative stress response at the early stage after PH,and thereby help to reduce the degree of systemic inflammatory response.%目的 观察大鼠肝部分切除术(PH)后给予腹腔神经丛阻滞(NCPB)对早期应激反应的影响.方法 30只健康清洁雄性SD大鼠,随机分为对照组和NCPB组,每组15只,均构建大鼠70％ PH模型.NCPB组在PH术毕关腹前给予0.5％利多卡因的NCPB,而对照组以0.9％生理盐水替换.分别于术后6h、12 h、24 h测定血清C反应蛋白(CRP)、皮质酮(GC)、促肾上腺皮质激素(ACTH)、去甲肾上腺素(NA)、肾上腺素(AD)浓度及肿瘤坏死因子(TNF)-α、白介素(IL)-1β水平,并通过Western blot分析外周血单核细胞(PBMCs)糖皮质激素受体(GR)的蛋白表达.结果 PH术后24h内大鼠产生明显的应激反应,术后血清CRP、GC、ACTH、NA及AD浓度均有不同程度的升高,但在相应时间点NCPB组均显著低于对照组(P＜0.01或P＜0.05);对照组PBMCs的GR蛋白表达在PH术后明显下降,在相应时间点NCPB组均显著高于对照组(P＜0.01);无论是对照组还是NCPB组的血清TNF-α和IL-1β水平在术后24 h内均逐渐升高,但在相应时间点NCPB组均显著低于对照组(P＜0.01或P＜0.05).结论 PH术中给予NCPB可有效抑制术后早期应激反应,有助于减轻全身性炎症反应.

摘要： 目的:观察连续膈肌脚后间隙神经阻滞对顽固性上腹部癌性疼痛的疗效.方法:71例中晚期上腹部癌痛患者,随机分单次腹腔神经丛阻滞(NCPB)组(N组)、连续膈肌脚后间隙神经阻滞组(C组)和单独镇痛药物组(D组).观察治疗前、后1周、1、2、4、6个月视觉模拟评分(VAS),吗啡用量和生存质量(QOL)及相关并发症情况.结果:3组治疗前后VAS评分均显著降低(P＜ 0.01),1周至4个月,N组、C组低于D组(P＜0.05),第6个月时,N组、D组差异不显著(P＞0.05).治疗后1-6个月疗效优良率D组低于N组、C组(P＜ 0.05).N组、C组治疗后吗啡用量低于D组,QOL均明显提高(P＜0.01).结论:神经阻滞联合镇痛药物优于单独药物治疗.连续膈肌脚后神经阻滞远期疗效及QOL改善优于单次NCPB治疗,可安全应用于临床治疗.

摘要： 目的：探讨腹腔神经丛阻滞在控制胰腺癌患者疼痛中的效果。方法选择2012年3月—2014年10月在该院就诊的100例采用腹腔神经丛阻滞的胰腺癌患者，采用简明疼痛问卷测量患者采用腹腔神经丛阻滞前后的疼痛情况。结果腹腔神经丛阻滞前患者的疼痛得分为（6．67±1．12）分，阻滞后得分为（2．11±0．49）分，疼痛影响得分术前为（5．81±2．19）分，术后为（1．98±0．51）分，差异有统计学意义（P ＜0．01）。结论腹腔神经丛阻滞可以有效控制胰腺癌患者的疼痛，减少疼痛对患者的不良影响。%Objective To explore the effects of neurolytic celiac plexus block in controlling pancreatic cancer patients’pain.Methods A hundred patients admitted to Xiangyang Central Hospital from March 2012 to October 2014 were recruited into this study.Self -designed demographic questionnaire and Brief Pain Inventory were used to test the pain of patients before and after they underwent neu-rolytic celiac plexus block.Results The pain intensity score was 6.67 ±1.12 before neurolytic celiac plexus block and 2.11 ±0.49 after.Parameters of interference with pain score was 5.81 ±2.19 before and 1.98 ±0.51 after.The difference was statistically signifi-cant(P <0.05).Conclusions Neurolytic celiac plexus block can manage pancreatic cancer patients’pain effectively and lessen ad-verse effects caused by pain.

摘要： Objective To explore the efficacy of three dimensional conformal radiotherapy combined with solar plexus block in the treatment of locally advanced pancreatic cancer pain, and to observe the safety, feasibil-ity and the patients′quality of life. Methods Sixty-three locally advanced pancreatic cancer patients were randomly divided into two groups:the control group (31cases) and the combination group (32cases). In the combi-nation group, ultrasound guided celiac plexus block was first performed. Then three-dimensional conformal radio-therapy was did 2 days later. In the control group, patients were treated with three dimensional conformal radia-tion therapy alone. The pain relief and KPS score were compared between the two groups before and after treat-ment. The security and feasibility of treatment were analyzed. Results The pain relief rates of the control group and combination group were 48.3% and 84.3% respectively. The increasing rate of KPS score in control group was not significant, but in the combination group, it was 56.3%. Conclusion Three dimensional confor-mal radiotherapy combined with solar plexus block technique is better in the treatment of locally advanced pan-creatic cancer patients. It can relieve pain and improve intervention the patient's quality of life.%目的:探讨三维适形放疗联合B超引导下无水酒精腹腔神经丛阻滞术治疗局部晚期胰腺癌的疼痛效果,判断其安全性和可行性及患者生活质量改善情况.方法:应用单因素分析方法,回顾性分析63例局部晚期胰腺癌患者的临床资料, 63例局部晚期胰腺癌患者根据随机数字表分成对照组(31例)和联合治疗组(32例),联合治疗组先行B超引导下腹腔神经丛阻滞术,术后第2 d进行三维适形放疗,对照组则仅采用三维适形放疗;比较两组治疗前后的疼痛缓解情况及Karnofsky评分情况,分析其安全性和可行性.结果:对照组和联合治疗组疼痛缓解率为48.3%和84.3%,对照组卡氏评分没有发生显著变化,联合治疗组卡氏评分提高率56.3%;两组间副反应差异不明显.结论:三维适形放疗联合腹腔神经丛阻滞术治疗局部晚期胰腺癌效果较单用三维适形放疗优越,能够缓解疼痛,提高患者生活质量.

摘要： 腹腔神经丛阻滞对腹部癌痛患者止痛治疗效果确切。超声引导下完成治疗操作相对简便，时间相对短。相对CT，MR引导下完成同样治疗费用更低。结合相应部肿瘤局部治疗(粒子等)能达到更持久的疗效。其缺点是，术中无去准确了解阻滞药物弥散情况。

摘要： 目的:观察CT引导经椎间盘穿刺法行内脏与腹腔神经丛阻滞对胰腺癌晚期癌性疼痛的疗效比较.rn 方法:48例胰腺癌晚期伴有上腹部癌性疼痛的患者,随机分为两组,在CT引导下分别行腹腔神经丛(N组)或经椎间盘穿刺行内脏神经(S组)无水乙醇毁损性阻滞.记录术前(T0)、术后第1天(T1)、第15(T2)、30(T3)、60(T4)、90(T5)天VAS评分,评估疗效;记录两组并发症和副作用的发生情况.rn 结果:各组内T1～T5时的VAS评分均较T0时降低(P<0.01),S组在T3～T5时较N组同期降低(P<0.05).术后第1天,S组与N组的总有效率分别为87.5%和83.3%.随时间延长该百分比均逐渐降低,至T5时分别为60.0%和42.9%,S组T3～T5时的总有效率较N组高.两组在治疗及随访期间两组均未发生严重并发症.rn 结论:内脏神经阻滞应用于胰腺癌晚期癌性疼痛的治疗,其远期疗效优于腹腔神经丛阻滞.CT引导下经椎间盘穿刺法行内脏神经阻滞,操作方便,安全有效.

摘要： 胰腺癌最突出的症状是剧烈疼痛，为缓解疼痛，提高病人的生存质量，本文分析了胰腺癌的发病特点，介绍了内脏痛的特点和机制，并就腹腔神经丛阻滞的临床应用及研究进展作一综述。

摘要： 作者采用了穿入淋巴结内腹腔神经丛阻滞的方法,提高了对部分常规方法难以奏效的癌性疼痛患者的治疗效果,本文介绍其手术方法及临床资料.

摘要： 本发明公开一种神经丛刺激系统、神经丛刺激器及刺激方法，主要针对传统的外周神经阻滞手术中神经丛定位不准确而设计。所述神经丛刺激系统包括：神经丛刺激器、辅助电极以及神经丛刺激针，所述辅助电极与所述神经丛刺激针经连接器与所述神经丛刺激器相连接；其中，所述神经丛刺激器包括：工作参数调节设置模块、微处理器、刺激脉冲发送控制模块、显示模块和电源模块。基于上述结构和刺激方法，本发明可客观、直接、精确地确定神经丛位置，避免了现有主观、难量化的盲探法所存在的诸多问题。

摘要： 本发明提供一种用于引起电神经阻滞的三节点电极及电神经阻滞系统。三节点电极包括电极体，第一导电表面和第二导电表面，所述第一导电表面和第二导电表面接收相同电信号，第三导电表面，所述第三导电表面接收所述相同电信号的另一侧，在工作时，第一和第二导电表面以及第三导电表面与皮肤接触，从而，所述相同电信号在由第一和第二导电表面以及第三导电表面形成的三角形内传输。本发明的三节点电极将三个导电表面布置在一个电极体上，直接将该三节点电极放置在疼痛位置处进行治疗即可，不需要放置多个分散的小电极，也不需要布置多根导联线，使得安装方便，如发生故障，也方便维护。

摘要： 本发明公开一种神经丛刺激系统、神经丛刺激器及刺激方法，主要针对传统的外周神经阻滞手术中神经丛定位不准确而设计。所述神经丛刺激系统包括：神经丛刺激器、辅助电极以及神经丛刺激针，所述辅助电极与所述神经丛刺激针经连接器与所述神经丛刺激器相连接；其中，所述神经丛刺激器包括：工作参数调节设置模块、微处理器、刺激脉冲发送控制模块、显示模块和电源模块。基于上述结构和刺激方法，本发明可客观、直接、精确地确定神经丛位置，避免了现有主观、难量化的盲探法所存在的诸多问题。

摘要： 本发明公开了一种外周神经阻滞和椎管内神经阻滞的辅助机器人装置，所述装置包括：患者阻滞部位固定系统、机械臂、超声探头、消毒杀菌装置、无菌耦合剂装置、计算机控制系统、自动进针装置。本发明提供的外周神经阻滞和椎管内神经阻滞的辅助机器人装置利用人工智能和计算机图像识别以及自动化控制等技术为基础，可视化精准穿刺至神经干(丛)周边、椎管硬膜外腔或蛛网膜下腔，达到精准麻醉的作用。

摘要： 本实用新型公开了一种用于神经丛连续阻滞的套件，包括留置管，金属丝，第一紧固连接装置或第二紧固连接装置；通过金属丝和紧固连接装置对留置管进行二次定位，使得留置管的定位准确率大幅上升。本实用新型所提出的套件，设计巧妙，使用方便，能够显著提高神经丛连续阻滞的成功率，适合在临床上大量推广。

摘要： 本实用新型公开了一种用于神经丛连续阻滞的留置管和套件，该留置管包括首端和尾端，首尾两端的外壁上分别设有金属涂层，留置管的管壁中设有连接首尾两端的金属涂层的金属导丝；该套件除了包括该留置管，还包括神经刺激针、固定器、导线或导线夹。本实用新型所提出的留置管及其组成的套件，结构简单，使用便利，能够大幅提高神经丛连续阻滞的成功率，并节省医护人员的时间成本和人力成本。

摘要： 本实用新型公开了一种连续神经丛阻滞套件，属于医疗器械设备技术领域。该实用新型的穿刺导针内设置有导药孔道，穿刺导针与推药导管连接成Y型结构，推药导管和穿刺导针均为金属材质，针尾活动套接设置有留置管连接件，推药导管端部的导药连接件一侧分别设置有导药连接管和电刺激导线，导药连接管与推药导管相互连通，电刺激导线与推药导管连接，留置导管为硅胶软管，留置导管内壁设置有螺旋状的金属丝，留置导管一侧活动设置有留置固定件，留置导管端部活动设置有导药接头。本实用新型结构设计合理，能够在超声实时监测下实现准确穿刺和置管，操作便捷高效，提升使用安全性，实现连续阻滞效果，满足使用的需要。

摘要： 本实用新型公开了一种腹腔神经丛穿刺弯针。其特征在于将针管弯曲成圆弧形，弧长L与针管圆弧半径R的关系为L/R＝π/2。本实用新型作腹腔神经丛穿刺，更符合穿刺部位椎体和周边组织的解剖学结构，穿刺简便，减少和避免穿刺中的意外损伤，提高了穿刺成功率。对腹部器官癌患者，止痛时间长，效果好，病人易接受。本实用新型设计合理，制作简单，社会和经济效益显著，具有广泛的应用价值，是新型腹腔神经丛穿刺针。

摘要： 本实用新型公开一种神经丛刺激系统及神经丛刺激器，主要针对传统的外周神经阻滞手术中神经丛定位不准确而设计。所述神经丛刺激系统包括：神经丛刺激器、辅助电极以及神经丛刺激针，所述辅助电极与所述神经丛刺激针经连接器与所述神经丛刺激器相连接；其中，所述神经丛刺激器包括：工作参数调节设置模块、微处理器、刺激脉冲发送控制模块、显示模块和电源模块。基于上述结构和刺激方法，本实用新型可客观、直接、精确地确定神经丛位置，避免了现有主观、难量化的盲探法所存在的诸多问题。

摘要： 本发明公开了一种用于治疗2型糖尿病的腹腔神经丛电刺激系统。该系统包括体外程控仪、个人控制器、植入患者侧腹部皮下发放电脉冲的体内刺激器、植入患者腹腔神经丛的电极；体外程控仪通过数据线与个人控制器连接，个人控制器通过射频通讯方式与体内刺激器连接，体内刺激器与电极通过导线连接。体外程控仪为安装腹腔神经丛电刺激系统操作软件的电脑；个人控制器集成功能模块E类放大器；体内刺激器包括射频接收器、微处理器、双通道脉冲发生器和电源系统四个功能单元；电极为双极电极。本发明发现了腹腔神经丛阻滞可用于2型糖尿病的治疗；本发明腹腔神经丛电刺激系统操作简单、方便、灵活，能有效治疗糖尿病，并发症少。