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curcumin

curcumin的相关文献在2000年到2023年内共计108篇,主要集中在肿瘤学、中国医学、基础医学 等领域,其中期刊论文108篇、相关期刊49种,包括中国药理学与毒理学杂志、华中科技大学学报(医学)(英德文版)、世界胃肠病学杂志:英文版等; curcumin的相关文献由468位作者贡献,包括Thierry Appelboom、Christian Mélot、Duan-Yong Liu等。

curcumin—发文量

期刊论文>

论文:108 占比:100.00%

总计:108篇

curcumin—发文趋势图

curcumin

-研究学者

  • Thierry Appelboom
  • Christian Mélot
  • Duan-Yong Liu
  • Hai-Mei Zhao
  • 吴裕丹
  • 陈燕
  • CHEN Yan
  • Chao Wang
  • Duangporn Thong-Ngam
  • Hai-Yang Yue
  • 期刊论文

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    • Yun-Qian Chang; Gui-Juan Zhou; Hong-Mei Wen; Duan-Qun He; Chen-Lin Xu; Ya-Rui Chen; Yi-Hui Li; Shuang-Xi Chen; Zi-Jian Xiao; Ming Xie
    • 摘要: Radiation therapy is considered the most effective non-surgical treatment for brain tumors.However,there are no available treatments for radiation-induced brain injury.Bisdemethoxycurcumin(BDMC)is a demethoxy derivative of curcumin that has anti-proliferative,anti-inflammatory,and anti-oxidant properties.To determine whether BDMC has the potential to treat radiation-induced brain injury,in this study,we established a rat model of radiation-induced brain injury by administe ring a single 30-Gy vertical dose of irradiation to the whole brain,followed by intraperitoneal injection of 500μL of a 100 mg/kg BDMC solution every day for 5 successive weeks.Our res ults showed that BDMC increased the body weight of rats with radiation-induced brain injury,improved lea rning and memory,attenuated brain edema,inhibited astrocyte activation,and reduced oxidative stress.These findings suggest that BDMC protects against radiationinduced brain injury.
    • Luhui Wang; Xinru Zhang; Junxia Xiao; Jiayi Shi
    • 摘要: The stability against various environmental stresses of the curcumin-loaded secondary and tertiary emulsions that was emulsified by whey protein isolate(WPI)and coated by chitosan(CHI),carboxymethyl konjac glucomannan(CMKGM),or their combination through layer-by-layer assembly was investigated.Generally,the multilayered emulsions were destabilized in high Na Cl concentrations or medium p H that could interrupt the electrostatic interaction between the three polyelectrolytes or deprotonate CHI,indicating that electrostatic interaction played an important role in the stability of emulsions.Compared with the primary emulsion that was solely stabilized by WPI,extra coating with CHI and CMKGM generally increased the stability of the emulsion against repeated freezing-thawing,improved the retention of curcumin against heating,UV irradiation,and long-term storage,and the effects were more remarkable in the tertiary emulsion with CMKGM locating in the outmost layer.Since CMKGM has shown the colon-targeted delivery potency,the multilayered emulsions assembled by layer-by-layer deposition,especially the tertiary emulsion,could be used as an effective carrier for the targeted delivery of curcumin.
    • Zhiyu Li; Wenxiu Hu; Jiajia Dong; Fidelis Azi; Xiao Xu; Chuanhai Tu; Sijie Tang; Mingsheng Dong
    • 摘要: Curcumin is a bioactive molecule with limited industrial application because of its instability and poor solubility in water.Herein,curcumin-loaded Pickering emulsion was produced using purified bacterial cellulose from fermented kombucha(KBC).The morphology,particle size,stability,rheological properties,and antioxidant activities of the curcumin-loaded Pickering emulsion were investigated.The fluorescence microscope and scanning electron microscopy images showed that the curcumin-loaded Pickering emulsion formed circular droplets with good encapsulation.The curcumin-load Pickering emulsion exhibited better stability under a wide range of temperatures,low p H,sunlight,and UV-365 nm than the free curcumin,indicating that the KBC after high-pressure homogenization improved the stability of the CPE.The encapsulated curcumin retained its antioxidant capacity and exhibited higher functional potential than the free curcumin.The study demonstrated that the KBC could be an excellent material for preparing a Pickering emulsion to improve curcumin stability and antioxidant activity.
    • Mengxia Duan; Jishuai Sun; Yequn Huang; Haixin Jiang; Yaqin Hu; Jie Pang; Chunhua Wu
    • 摘要: Recently,food grade nanofiber-based materials have received growing attentions in food packaging.In this work,novel active and intelligent packaging nanofibers based on gelatin/chitosan with curcumin(GA/CS/CUR)were developed via electrospinning technique.Effects of the incorporation of CUR content(0.1%-0.3%,m/m)on the microstructure and functional properties of the electrospun nanofibers were investigated.Morphological studies using scanning electron microscopy indicated that loading CUR can affect the average diameter of nanofiber mats,which remained around 160-180 nm.The addition of an appropriate level CUR(0.2%,m/m)led to a stronger intermolecular interaction,and thus enhanced the thermal stability and tensile strength of the obtained nanofibers.Meanwhile,the incorporation of CUR significantly improved antioxidant activity and the antimicrobial activity of GA/CS/CUR nanofibers.Moreover,the sensitivity of nanofibers to ammonia results indicated that GA/CS nanofibers containing 0.2%CUR(GA/CS/CURⅡ)presented high sensitivity of colorimetric behavior to ammonia(within 3 min).These results suggest GA/CS/CURⅡnanofibers has great potential as a multifunctional packaging to protect and monitor the freshness of proteinrich animal foods,such as meat and seafood.
    • Zhuo Zhang; Yiqi Yang; Hongbo Zhang; Shengbing Yang; Ruixue Yin; Wenjun Zhang
    • 摘要: 3D Bioprinting plays an irreplaceable role in bone tissue engineering. Shellac and curcumin are two natural compounds that are widely used in the food and pharmaceutical sectors. In this study, a new composite scaffold with good biocompatibility and antibacterial ability was manufactured by adding shellac and curcumin into the traditional bone scaffold through low-temperature three-dimensional printing (LT-3DP), and its impact on the osteoimmune microenvironment was evaluated.
    • Wen-hui FAN; Feng-chun WANG; Zhi JIN; Lin ZHU; Jian-xin ZHANG
    • 摘要: Objective:Colorectal cancer(CRC)is one of the most lethal and prevalent malignancies world-wide.Currently,surgery,radiotherapy and chemotherapy are clinically applied as common approaches for CRC patients.Cisplatin is one of the most frequently used chemotherapy drugs for diverse cancers.Although chemotherapeutic strategies have improved the prognosis and survival of cancer patients,development of cisplatin resistance has led to cancer recurrence.Curcumin,isolated from turmeric,has been used as an effective anti-cancer agent.However,the molecular mechanisms for curcumin-mediated cisplatin sensitivity of CRC have not been elucidated.
    • Lei WANG; Lijun FU; Yongcun WANG; Xiangdong WANG; Shangqing ZHANG; Yuxiang LU; Liang ZHANG; Hefeng ZHANG
    • 摘要: [Objectives]This study was conducted to establish a mathematical model for supercritical CO_(2) extraction of curcumin.[Methods]With ginger as the experimental raw material,a quadratic polynomial mathematical model of the yield of curcumin extracted by supercritical CO_(2) was established by response surface methodology(RSM).The validity of the mathematical model was verified,and the effects of extraction temperature(60-70°C),pressure(30-50 MPa)and time(70-90 min)on curcumin yield were analyzed.[Results]According to the model,the process parameters were optimized.Taking curcumin yield as the index,the optimal process conditions for supercritical CO_(2) extraction obtained were:temperature 62.6°C,pressure 37.7 MPa,time 82.9 min,under which the yield of curcumin was as high as 7.34%.Under the optimal extraction conditions,curcumin had a certain reducing capacity,and showed strong scavenging capacities to·OH,O_(2)^(-)·and DPPH,and its IC_(50) values were 9.40,9.03 and 8.04 mg/ml,respectively.Therefore,it is feasible to extract curcumin from ginger using supercritical CO_(2).[Conclusions]This study provides a theoretical basis for the development and utilization of curcumin.
    • Panpan GUO; Ting HAN
    • 摘要: [Objectives]To analyze the current research situation,hotspots and trends of curcumin and diabetes in recent 10 years.[Methods]Web of Science database was set as data source,the annual number of papers,the distribution of authors,the distribution of country/institution,the distribution of journals,the distribution of key words in the literature about curcumin and diabetes from January 1,2010 to March 31,2021 were quantitatively and visually analyzed with the aid of visualization software Bibliometrix.[Results]A total of 475 articles were included,and the annual number of papers was on the rise;the top three high-yielding countries were China(120 papers),India(65 papers),and the United States(58 papers).In terms of international cooperation,China and the United States had the most cooperation(27 papers);the top three high-yielding institutions were Wenzhou Medical University(42 papers),Mashhad University of Medical Sciences(41 papers)and Tehran University of Medical Sciences(30 papers);the most frequently cited authors were Wang Y(19 times),Li X(13 times),Li Y(12 times),Liang G(12 times)and Zhang Y(12 times);the top three journals in number of papers were Diabetology&Metabolic Syndrome(8 papers),PLoS One(8 papers),and European Journal of Pharmacology(7 papers),and the h index was 7,8,and 6,respectively;the most frequently cited journals were Diabetes(496 times),Journal of Biological Chemistry(486 times),PLoS One(347 times),Diabetes Care(284 times),and European Journal of Pharmacology(229 times);the most frequent key words mainly included oxidative stress,curcumin,insulin-resistance and expression;the hotspots were insulin resistance and NF-κB,mainly focusing on in vitro experiments.[Conclusions]The curcumin has good therapeutic potential in improving insulin resistance,inhibiting inflammation and oxidative stress,etc.The results are expected provide a reference and basis for scientific researchers to understand the current situation of curcumin and diabetes research and carry out the further research.
    • Cristina Pereira-Wilson
    • 摘要: Activating mutations in the oncogenes KRAS,BRAF and PI3K define molecular colorectal cancer(CRC)subtypes because they play key roles in promoting CRC development and in determining the efficacy of chemotherapeutic agents such as 5-fluorouracil and anti-epidermal growth factor receptor monoclonal antibodies.Survival of patients with cancers displaying these molecular profiles is low.Given the limited efficacy of therapeutic strategies for CRC presenting mutational activations in mitogen-activated protein kinase and/or PI3K pathways,developing combination therapies with natural flavonoids or other phytochemicals with demonstrated effects on these pathways(and little or no toxic effects)may constitute a valuable path forward.Much has been published on the anticancer effects of dietary phytochemicals.However,even an exhaustive characterization of potential beneficial effects produced by in vitro studies cannot be extrapolated to effects in humans.So far,the available data constitute a good starting point.Published results show quercetin and curcumin as possibly the best candidates to be further explored in the context of adjuvant CRC therapy either as part of dietary prescriptions or as purified compounds in combination regimens with the drugs currently used in CRC treatment.Clinical trial data is still largely missing and is urgently needed to verify relevant effects and for the development of more personalized treatment approaches.
    • 郑锐年; 孙成晖; 贾筠; 林顺欢; 林钦雄; 刘淳; 郝艳艳; 潘学兵; 何宇; 邵俊伟
    • 摘要: 目的探讨Curcumin协同ABT-737对肝癌7404细胞上皮间质转化(epithelial-mesenchymal transition,EMT)的抑制作用及机制研究。方法2μmol/L Curcumin、5μmol/L ABT-737或2μmol/L Curcumin+5μmol/L ABT-737作用肝癌7404细胞后,观察细胞形态的变化,细胞划痕实验检测7404细胞的迁移能力,蛋白质印迹法检测7404细胞中E-cadherin、Vimentin、N-cadherin、ZEB1蛋白的表达和p-beta-catenin、p-JNK、Snail、Twist蛋白的表达。构建肝癌动物模型(Alb-Cre;P53f/f;Ras),在苏木精伊红染色下观察肝转移瘤情况,并对在肝脏形成的转移灶进行数量统计。结果相比2μmol/L Curcumin、5μmol/L ABT-737,2μmol/L Curcumin+5μmol/L ABT-737作用后,7404细胞梭形化明显减少(P<0.05),细胞迁移能力显著降低(P<0.05),Vimentin、N-cadherin、ZEB1蛋白的表达水平明显抑制(P<0.05),E-cadherin蛋白的表达水平明显上调(P<0.05),beta-catenin和JNK的磷酸化水平明显上调(P<0.05),beta-catenin下游靶基因Snail、Twist的表达水平明显抑制(P<0.05)。相比对照组,Curcumin+ABT-737作用后,肝癌动物模型(Alb-Cre;P53f/f;Ras)中肝转移瘤数量明显减少(P<0.05)。结论Curcumin协同ABT-737能抑制肝癌细胞上皮间质转化,JNK-beta-catenin可能参与EMT转化的抑制。
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