摘要:
目的:探讨不同剂量右美托咪定(Dex)复合丙泊酚对老年无痛肠镜检查的麻醉效果.方法:选取2016年11月~2017年10月我院择期行无痛纤维结肠镜检查的老年患者60例为研究对象,依据Dex用量分为低剂量组和高剂量组.检查前10 min采用微量输液泵静脉泵注Dex,低剂量组泵入负荷量为0.25 μg/kg,高剂量组为0.75 μg/kg,10 min泵注完毕,然后以0.5 μg/kg/h速度持续泵注,直至检查完毕.Dex负荷量泵注完毕后,以丙泊酚1~1.5 mg/kg缓慢静脉注射.于用药前(T0)、进镜后5 min(T1)、检查结束时(T2)分别记录平均动脉压(MAP)、心率(HR)、血氧饱和度(SpO2);使用生物电阻抗技术持续监测每搏输出量(SV)、心排出量(CO)、外周血管阻力(SVR);记录可唤醒时间、丙泊酚用量、离院时间.结果:2组患者T0时MAP、HR、SpO2相比无明显差异(P>0.05),T1、T2时MAP、HR、SV、CO、SVR低于T0时(P<0.05),SpO2无明显变化(P>0.05).高剂量组MAP在T1时高于同期低剂量组,HR在T1、T2时低于同期低剂量组(P<0.05);剂量组T1、T2时SV、CO、SVR均高于同期低剂量组(P<0.05).高剂量组患者可唤醒时间短于低剂量组,丙泊酚用量少于低剂量组(P<0.05),离院时间无明显差异(P>0.05).结论:高剂量Dex可减少老年无痛纤维结肠镜检查术患者丙泊酚用量,且不增加呼吸、循环的抑制作用.%Objective:To explore the anesthetic effect of dexmedetomidine (Dex) in different doses in combined with propofol on the painless colonoscopy in the elder patients.Methods:A total of 60 elder patients who were admitted in our hospital from November,2016 to October,2017 for selective painless fiber colonoscopy were included in the study and divided into the low dose group and high dose group according to Dex dose.The micro-infusion pump was used to inject Dex 10 min before examination.The load capacity in the low dose group was 0.25 μg/kg,while in the high dose group was 0.75 μg/kg.The pump injection was completed within 10 min,then a continuous pump injection was performed in a speed of 0.5 μg/kg/h until the check off.After the completion of Dex pumping,propofol (1~1.5 mg/kg) was slowly injected.MAP,HR,and SpO2 before medication (T0),5 min after inserting the endoscope (T1),and the time after the examination being finished (T2) were recorded,respectively.The bioelectrical impedance technic was used to continuously monitor SV,CO,and SVR.The awakening time,propofol dose,and discharge time were recorded.Results:The comparison of MAP,HR,and SpO2 at T0 between the two groups was not statistically significant (P>0.05).MAP,HR,SV,CO,and SVR at T1 and T2 were significantly lower than those at T0(P<0.05),while the comparison of SpO2 was not significantly changed (P>0.05).MAP at T1 in the high dose group was significantly higher than that in the low dose group,while HR at T1 and T2 was significantly lower than that in the low dose group (P<0.05).SV,CO,and SVR at T1 and T2 in the high dose group was significantly higher than those in the low dose group (P<0.05).The awakening time in the high dose group was significantly shorter than that in the low dose group,and the propofol dose was significantly less than that in the low dose group (P<0.05),while the comparison of discharge time was not significantly different (P >0.05).Conclusions:Application of Dex in a high dose in the painless colonoscopy in the elder patients can reduce the propofol dose,and will not increase the inhibiting effect on respiration and circulation.