糖尿病,非胰岛素依赖型

摘要： 目的 观察针刺加闪罐治疗老年2型糖尿病胃轻瘫患者的临床疗效.方法 104例符合纳入标准的患者作为研究对象,随机分为治疗组和对照组,每组52例.对照组口服多潘立酮片,治疗组在对照组基础上加用针刺、闪罐治疗.8周后观察恶心/呕吐、反酸/嗳气、早饱、上腹胀痛症状改善情况,胃排空率及临床疗效差异.结果 治疗组临床疗效明显高于对照组(P<0.05).治疗组治疗后恶心/呕吐、反酸/嗳气、早饱、上腹胀痛评分明显低于对照组(P<0.05).两组治疗后4 h胃排空率比较差异具有统计学意义(P<0.05).结论 针刺加闪罐能提高糖尿病胃轻瘫患者的胃排空率,有效改善临床症状,提高临床疗效.

摘要： 目的 观察耳部放血联合针刺疗法对2型糖尿病患者血糖的影响.方法 将60例2型糖尿病患者随机分为治疗组和对照组,每组30例.对照组采用常规药物治疗,治疗组在对照组基础上采用耳部放血联合针刺疗法.治疗3个月后,观察两组治疗前后空腹血糖、餐后2 h血糖和糖化血红蛋白的变化情况.结果 治疗组治疗后空腹血糖、餐后2 h血糖和糖化血红蛋白与同组治疗前比较差异均具有统计学意义(P<0.01).治疗组治疗后各项指标与对照组比较差异均具有统计学意义(P<0.01).治疗组总有效率明显优于对照组,差异有统计学意义(P<0.01).结论 耳部放血联合针刺疗法是一种治疗2型糖尿病的有效方法,具有较好的降糖作用.

摘要： Objective:To investigate the CT features of patients with type 2 diabetes mellitus complicated with pulmonary tuberculosis.Methods:98 patients with type 2 diabetes comphcated with pulmonary tuberculosis were selected as research group;100 cases of non diabetic patients with pulmonary tuberculosis treated at the same period were selected as control group;the clinical data and CT imaging features were compared between the two groups.According to the duration of diabetes,research group was further divided into the study group A (DM duration ≥ 10 years,n =50) and the study group B (DM duration ＜ 10 years,n =48)to compare the effects of different diabetic courses on the clinical data and CT imaging features.Results:In the study group,61 (63.26％) cases had comorbidities,such as hypertension,chronic renal failure,heart failure and arrhythmia,which were significantly higher than those in the control group,differences were statistically significant (P ＜,0.001).Double lung lesions (OR,2.39;95％ CI,1.34 ～4.25;P =0.003),all lobe lesion (OR,2.79;95％ CI,1.24 ～6.27;P =0.013) and lymphadenopathy (OR,1.98;95％ CI,1.10～3.55;P=0.022) were independent predictors of DM with TB.The average age of the patients in the study group A was higher than that in the study group B (P ＜ 0.05).There was no significant difference in CT imaging between two groups of TB patients with different DM courses (P ＞ 0.05).Conclusion:Patients with type 2 diabetes mellitus complicated with pulmonary tuberculosis infection CT imaging showed bilateral lung lesions,involving all lung and lymph nodes;CT can help strengthen the diagnosis of patients and provide the basis and reference for the clinical treatment.%目的:探讨2型糖尿病(DM2)并发肺结核(TB)感染患者的CT影像特征.方法:DM2并发TB感染患者98例作为研究组,同时选取同期入院治疗的TB非糖尿病(DM)患者100例作为对照组,对比两组患者的临床资料及CT影像特征;研究组中根据DM病程长短进一步将研究组分为研究组A(DM病程≥10年,n=50)和研究组B(DM病程＜10年,n=48),对比不同DM病程患者临床资料及CT影像特征.结果:研究组患者中61例(63.26％)具有高血压、慢性肾功能不全、心衰、心律失常等合并症,显著高于对照组患者,差异有统计学意义(P＜0.001);双肺病变(OR,2.39;95％ CI,1.34 ～4.25;P =0.003)、所有肺叶病变(OR,2.79;95％ CI,1.24～6.27;P=0.013)以及淋巴结肿大(OR,1.98;95％ CI,1.10 ～3.55;P =0.022)均为DM合并TB的独立预测因素;在研究组中,研究组A患者的平均年龄高于研究组B患者(P＜0.05);两组不同病程DM2合并TB患者的CT影像学表现差异无统计学意义(P＞0.05).结论:DM2合并TB患者的CT检查有明显示影像子特征,认识这些特征有助于准确诊断和临床治疗方案的选择.

摘要： 目的：建立2型糖尿病周围神经病变（ DPN）大鼠模型。方法：SD大鼠40只分为对照组（10只）和模型组（30只），模型组予高脂高糖饲料喂养及2~3次小剂量腹腔注射1%的链脲佐菌素（ STZ）建立糖尿病（ DM）动物模型，对照组给予普通饲料喂养并注射同等剂量生理盐水，模型组中DPN造模成功的作为DPN组， DPN造模不成功但DM造模成功的作为DM组；于实验第14周后，检测大鼠坐骨神经动作电位传导速度、血清神经生长因子（ NGF）水平及坐骨神经病理形态学变化。结果：30只大鼠中DM成模24只，其中15只大鼠并发DPN，DPN成模率62.5%；与对照组相比，DPN组大鼠坐骨神经动作电位传导速度、血清NGF含量均明显降低（ P﹤0.05）；与DM组相比，DPN组大鼠血清NGF含量明显降低（ P﹤0.05）。结论：高脂高糖饮食联合腹腔注射STZ可成功制作DPN大鼠模型，其机制与大鼠血清NGF水平降低有关。%Objective:To establish Type II diabetic peripheral neuropathy model of rats. Methods:40 SD rats were divided into normal control group(Group A,10)and model group(Group B,30);Group B fed with high fat and sugar diet. Giving Group B 2 to 3 times of small dose of intraperitoneal injection of 1% STZ concentration and use self-made mold to form the diabetes model. Group A fed with normal diet and equal amount of saline water. Group B DPN model was established successfully and then used as DPN group;DPN modeling failed ones but DM modeling succeed ones were used as DM group. 14 weeks later,ratsˊsciatic potential conduction velocity,NGF and sciatic pathomorphology was tested. Results:Out of 30 rats,24 succeeded in DM modeling,15 rats were complicated by DPN,DPN modeling success rate was 62. 5%;comparing with control group,ratsˊsciatic potential conduction velocity and NGF of DPN group decreased significantly( P ﹤0 . 05 );comparing with DM group,NGF content of DPN group decreased significantly(P﹤0. 05). Conclusion:The method can successfully induce the establishment of type 2 diabetic peripheral neuropathy model,the mechanism is correlated with ratsˊserum NGF level decrease.

摘要： Objective:To investigate the correlation of vitamin D( VD)levels with serum folic acid ( FA)levels and homocysteine( HCY)levels in type 2 diabetes. Methods:87 patients with type 2 di-abetes were selected as the observation group,and 90 healthy subjects were selected as control group. The serum levels of VD,FA and HCY of the two groups were measured and compared,and the corre-lation between these 3 components was analyzed. Results:The serum levels of VD and FA in the ob-servation group were significantly lower than those in the control group( P﹤0 . 05 ). The serum levels of HCY in the observation group were significantly higher than those in the control group( P﹤0 . 05 ). VD levels was positively correlated with FA levels and negatively correlated with HCY levels ,and FA lev-els was negatively correlated with HCY levels in the two groups. Conclusion:The levels of VD in pa-tients with type 2 diabetes was low,and the serum VD level was correlated with FA and HCY.%目的：探讨2型糖尿病血清中维生素D（ VD）水平与叶酸（ FA）、同型半胱氨酸（ HCY）的相关性。方法：选取87例2型糖尿病患者作为观察组，90例健康体检者为对照组，测定并比较两组被检者血清中VD与FA、HCY水平，并比较这3种成分的相关性。结果：观察组血清中VD、FA水平明显低于对照组，差异均具有统计学意义（P﹤0.05）；而HCY水平明显高于对照组，差异具有统计学意义（P﹤0.05）；两组被检者血清中VD与FA水平呈正相关，与HCY水平呈负相关，FA与HCY水平呈负相关。结论：2型糖尿病患者VD含量较低，且血清中VD与FA、HCY水平有相关性。

摘要： Objective To investigate the effect of acupuncture plus astragalus polysaccharide on the expression of Bcl-2 protein in pancreatic islet b cells in db/db mice. Method C57BL/Ksj-db/db mice as an animal model of spontaneous type 2 diabetes were selected for this experiment. Five-week-old db/db mice were randomized into model, acupuncture, medication and acupuncture+medication groups. Meanwhile, db/m mice were selected as a normal group. The acupuncture group received acupuncture at points Housanli (equivalent to Zusanli, ST36), Neiting(ST44) and Yishu(Extra) and the medication group, an oral gavage of astragalus polysaccharide (1400 mg/kg). Both groups were treated once daily, for 12 consecutive weeks. After the end of experiment, blood glucose, insulin and resistin were measured, and the expression of Bcl-2 protein in islet b cells was determined by immunohistochemical method. Result Blood glucose, insulin and resistin levels were significantly lower in the acupuncture+medication, acupuncture and medication groups than in the model group. They were significantly lower in the acupuncture+medication group than in the acupuncture and medication groups and significantly lower in the acupuncture group than in the medication group. The expression of Bcl-2 protein in islet b cells was higher in the medication, acupuncture and acupuncture+medication groups than in the model group; there was a statistically significant difference (P0.05). Conclusion Acupuncture plus astragalus polysaccharide can significantly reduce blood glucose and serum insulin and resistin levels and increase the expression of Bcl-2 protein in islet b cells to effectively inhibit apoptosis in islet b cells in db/db mice. Its effect is better than that of acupuncture alone or medication.%目的：观察针刺联合黄芪多糖对 db/db 小鼠胰岛b细胞 Bcl-2蛋白表达的影响。方法选用自发性2型糖尿病动物模型C57BL/Ksj-db/db 小鼠为本实验动物模型。将5周龄db/db 小鼠随机分为模型组、针刺组、药物组和针药组，同时将db/m小鼠作为正常组。针刺组大鼠取后三里(相当于足三里)、内庭和胰俞穴予针刺治疗，药物组用黄芪多糖(1400 mg/kg)灌胃，针药组同时给予针刺和药物治疗，均每日1次，连续12星期。实验结束后，采血检测血糖、胰岛素和抵抗素，免疫组化检测胰岛b细胞 Bcl-2的蛋白表达。结果在血糖、胰岛素和抵抗素水平方面，针药组、针刺组、药物组显著低于模型组，针药组显著低于针刺组和药物组，针刺组显著低于药物组；在对胰岛b细胞 Bcl-2蛋白表达的影响方面，药物组、针刺组及针药组 Bcl-2的表达均高于模型组，差异有统计学意义(P＜0.01)；针药组 Bcl-2的表达高于药物组(P＜0.01)；药物组与针刺组 Bcl-2的表达基本相同，未见明显差异(P＞0.05)。结论针刺联合黄芪多糖能够显著降低 db/db 小鼠血糖、血清胰岛素和抵抗素水平，提高胰岛b细胞 Bcl-2蛋白的表达水平，从而有效抑制胰岛b细胞的凋亡，作用强于单一针刺治疗和药物治疗。

摘要： 目的:观察中药养阴消渴汤结合西药治疗老年2型糖尿病的临床疗效.方法:选择2012年3月-2014年3月本院收治的120例确诊为2型糖尿病患者为研究对象,将其随机分为对照组60例和治疗组60例.对照组患者接受常规西药治疗(门冬胰岛素注射液),治疗组在此基础上给予自制的养阴消渴汤治疗.观察两组患者治疗前后空腹血糖(FPG)及餐后2小时血糖(2hPG)及糖化血红蛋白(HbAlc)的含量变化.治疗1个月后,对两组患者的临床效果进行比较.结果:两组患者的FPG、2hPG及HbAlc均比治疗前有明显改善(P＜0.05),并且治疗组改善效果较对照组更加显著(P＜0.05);治疗组患者的总有效率明显高于对照组(P＜0.05).结论:在老年2型糖尿病治疗中采用自拟养阴消渴汤能够取得比较良好的临床效果,值得借鉴使用.

摘要： 目的:探讨2型糖尿病合并缺血性脑卒中的临床特点和危险因素.方法:544例2型糖尿病患者按是否合并缺血性脑卒中分为合并脑卒中组及单纯糖尿病组,比较不同性别的2型糖尿病合并缺血性脑卒中患病率,比较两组患者年龄、吸烟、饮酒、血压及各生化指标,采用多元Logistic回归分析2型糖尿病合并缺血性脑卒中的危险因素.结果:女性2型糖尿病合并缺血性脑卒中患病率高于男性,合并脑卒中组高血压患病率高于单纯糖尿病组;多元Logistic回归分析结果显示年龄、糖尿病病程、尿Alb/Cr及颈动脉斑块是2型糖尿病合并缺血性脑卒中的危险因素.结论:2型糖尿病合并缺血性脑卒中以女性居多,其重要危险因素是高龄、糖尿病病程、颈动脉斑块和尿Alb/Cr升高.

摘要： 目的:探讨硒酵母联合左旋甲状腺素治疗2型糖尿病(T2DM)伴桥本甲状腺炎(HT)的效果.方法:60例确诊为T2DM伴HT患者随机均分为试验组和对照组,试验组采用200 mg/d硒酵母联合12.5 μg/d左旋甲状腺素(L-T4)治疗,对照组采用常规L-T4治疗,疗程3月;分别于治疗前及治疗3月时,采用电化学发光法测定两组患者血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺激素(TSH)水平,微粒子酶免疫法测定甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)水平,记录3月时两组患者甲状腺肿胀、甲状腺疼痛、黏液性水肿及腹痛缓解情况.结果:两组患者治疗前各指标比较,差异无统计学意义(P＞0.05);治疗3月时,对照组仅FT3水平低于治疗前(P＜0.05);试验组FT3、TGAb及TPOAb水平低于治疗前,TGAb及TPO-Ab水平也低于对照组(P＜0.05);治疗3月时,试验组甲状腺肿胀、甲状腺疼痛、黏液性水肿以及腹痛等症状发生率显著低于对照组(P＜0.05).结论:L-T4与硒酵母联合应用能有效降低糖尿病伴HT患者血清TGAb、TPO-Ab水平,缓解甲状腺功能减低的症状.

摘要： 本发明公开了一种治疗非胰岛素依赖型和胰岛素依赖型糖尿病的药物。以黄芪、黄精、黄连、红参、玄参、丹参、生山药、生花粉、葛根、益智仁(盐水炒)、车前子、苍术、升麻、柴胡、陈皮、茯苓、白术、甘草。制成的汤剂、散剂、胶囊对治疗非胰岛素依赖型和胰岛素依赖型糖尿病有特效。本发明临床已治愈近100例。其治愈率、显效率、总有效率为99％。

摘要： 本发明提供治疗和诊断与高血糖症相关的疾病，包括糖尿病、胰岛素抵抗等疾病的方法和组合物。基因多态性显示与疾病易感性相关，且它们的检测被用于诊断这些病症的诱因。相应的蛋白质用作介入治疗的靶。

摘要： 本发明公开了一种治疗非胰岛素依赖型和胰岛素依赖型糖尿病的药物。以黄芪、黄精、黄连、红参、玄参、丹参、生山药、生花粉、葛根、益智仁(盐水炒)、车前子、苍术、升麻、柴胡、陈皮、茯苓、白术、甘草。制成的汤剂、散剂、胶囊对治疗非胰岛素依赖型和胰岛素依赖型糖尿病有特效。本发明临床已治愈近100例。其治愈率、显效率、总有效率为99％。

摘要： 本发明涉及一种治疗胰岛素依赖型或非胰岛素依赖型糖尿病及糖尿病合并症的中药与中药提取物相结合的纯中药制剂及制备方法。配方是由：黄连提取物、葛根提取物、鳝鱼提取物、桑叶浸膏粉等七味中药组成。按工艺流程制成超高倍浓缩浸膏(按15％浓缩比例)，低温干燥。然后与中药提取物相结合，拌匀。采用超微粉加工技术进行加工。剂型为胶囊剂(或者开发成糖衣片剂)。适用于胰岛素依赖型或非胰岛素依赖型糖尿病及糖尿病合并病。其特点：服药疗程短，临床症状消失快，降低血糖快。有广泛的使用及推广价值，适合于国内外规格化生产。

摘要： 一种治疗胰岛素依赖型和非依赖型糖尿病药物的制备方法，由佩兰、地骨皮、人参籽、生山药、升麻、莲子心、五加皮、银耳、山楂核、决胆子和芦根等成分组成。首先取上述各组分的药物饮片，先后经过混合、干燥和粉碎后制成粉状药物，其次取上述二倍组分的药物饮片，经煎煮、过滤和浓缩制膏状药物，最后将粉状和膏状药物经温合、烘干、粉碎和灭菌后制成，它对胰岛素依赖型和非依赖型糖尿病及各类型糖尿病均有显著疗效，无副作用。

摘要： 本发明提供通过向患者施用治疗有效量的噻唑烷二酮衍生物和/或相关化合物来减少非胰岛素依赖型糖尿病患者外源性胰岛素给药量的方法。

摘要： 一种防治糖尿病药食兼用营养素及制造方法，由嘌呤类核苷酸、复合维生素、复合微量元素、复合矿物质、必需脂肪酸油并辅以适量食用纤维素作填充剂和降糖剂组成，用作食品、药品及其主剂或添加剂。防治糖尿病必须要从根本病因入手即首先必需解决好胰岛素与高血糖素的平衡，其次是胰岛和肾的功能修复，第三是防治并发症，第四是恢复正常的物质合成与代谢功能，才能治表又治本。本发明采用c－GMP等和微量元素锰调控(减少)高血糖素的第二信使c－AMP量及寿命而调控了高血糖素的活性和释放时间，矿物质碳酸钙可缓冲和中和酮等酸性物质而减缓酸中毒、柠檬酸钾的钾离子可补偿糖尿病“多饮”失去的过量的钾以利维持和维护酸碱和电解质平衡等，且无毒副作用和药物依赖性、可长期使用，目前多数药物所难做到，这些对防治糖尿病均极重要。

摘要： 一种防治非胰岛素依赖型糖尿病药食兼用营养素及制造方法，由嘌呤类核苷酸、复合维生素、复合微量元素、复合矿物质、必需脂肪酸油并辅以适量食用纤维素作填充剂和降糖剂组成，用作食品、药品及其主剂或添加剂。防治糖尿病必须要从根本病因入手即首先必需解决好胰岛素与高血糖素的平衡，其次是胰岛和肾的功能修复，第三是防治并发症，第四是恢复正常的物质合成与代谢功能，才能治表又治本。本发明采用c－GMP等和微量元素锰调控(减少)高血糖素的第二信使c－AMP量及寿命而调控了高血糖素的活性和释放时间，矿物质碳酸钙可缓冲和中和酮等酸性物质而减缓酸中毒、柠檬酸钾的钾离子可补偿糖尿病“多饮”失去的过量的钾以利维持和维护酸碱和电解质平衡等，且无毒副作用和药物依赖性、可长期使用，目前多数药物所难做到，这些对防治糖尿病均极重要。

摘要： 提供采用特定的类维生素A化合物,在有相当风险发生非胰岛素依赖型糖尿病(NIDDM)的受治疗者中治疗和/或预防NIDDM的方法,所述类维生素A化合物在结构上与9－顺式视黄酸相关,它们诱导前脂肪细胞分化为脂肪细胞。这些化合物可以单独给予或结合其它抗糖尿病发生药(诸如噻唑烷二酮)一起给予。

摘要： 本发明提供治疗和诊断与高血糖症相关的疾病，包括糖尿病、胰岛素抵抗等疾病的方法和组合物。基因多态性显示与疾病易感性相关，且它们的检测被用于诊断这些病症的诱因。相应的蛋白质用作介入治疗的靶。