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神经吻合

神经吻合的相关文献在1987年到2022年内共计95篇,主要集中在外科学、基础医学、神经病学与精神病学 等领域,其中期刊论文88篇、会议论文4篇、专利文献86679篇;相关期刊60种,包括国际外科学杂志、河南外科学杂志、临床骨科杂志等; 相关会议4种,包括2011第七届全军手外科会议、中华医学会2011年显微外科学术年会、2009年度宋儒耀整形外科青年医师论坛等;神经吻合的相关文献由296位作者贡献,包括杨继庆、王彦刚、段新民等。

神经吻合—发文量

期刊论文>

论文:88 占比:0.10%

会议论文>

论文:4 占比:0.00%

专利文献>

论文:86679 占比:99.89%

总计:86771篇

神经吻合—发文趋势图

神经吻合

-研究学者

  • 杨继庆
  • 王彦刚
  • 段新民
  • 刘卫平
  • 王斯刚
  • 龙开平
  • 章翔
  • 侯春林
  • 刘顺利
  • 刘鲁伟
  • 期刊论文
  • 会议论文
  • 专利文献

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    • 徐纪伟; 孙丹华; 陈旭东
    • 摘要: 目的:观察移植脊神经前后根重建脊髓白质纤维束的形态学情况。方法:取4周龄SD大鼠,分为移植组、损伤组和假手术组。移植组损伤第10~12胸段脊髓,然后切取脊髓损伤区废用的脊神经前根和后根,并将前根移植到脊髓损伤区域的皮质脊髓束位置,再将后根移植到薄束位置,脊髓与移植的神经根进行显微吻合,同时切取第12、13肋间神经连接损伤节段上下的脊神经,留置导管给予胶质细胞源性神经营养因子(GDNF)、轴突生长相关蛋白(GAP-43)、突触分化诱导基因产物1(SynDIG1)。损伤组仅损伤第10~12胸段脊髓。假手术组仅切开皮肤和分离肌肉,不损伤脊髓。术后7、30、60、90 d,行斜板实验、BBB功能运动评分、神经电生理检测方法检测3组大鼠运动功能。免疫荧光染色显示移植区脊髓组织吻合段神经组织结构变化及神经细胞的活性。结果:肉眼观察损伤组脊髓组织缺损、断端出现萎缩现象,移植组脊髓吻合段组织光滑圆润,没有明显萎缩现象,吻合段在显微镜下可见神经纤维排列整齐、走行一致。移植组斜板实验、BBB功能运动评分明显高于损伤组,体感电位、运动诱发电位潜峰时较损伤组明显缩短。结论:移植脊神经前后根重建脊髓白质纤维束,神经组织结构吻合修复良好,有利于神经信号传递,促进下肢运动功能的恢复。
    • 岳凤文; 刘力萍; 孙广峰; 吴祥奎; 魏在荣; 王达利
    • 摘要: OBJECTIVE: To investigate the efficacy of autologous peripheral blood mononuclear cells in the treatment of high radial nerve injury. METHODS: From April 2011 to September 2015, 12 cases of radial nerve injury in the middle arm were treated. Preoperatively peripheral blood mononuclear cells were mobilized, and then 15 mL of mononuclear cell suspension was prepared on the operation day. Radial nerves scheduled for anastomosis were surgically explored and subjected to end-end anastomosis using outer membrane suturing under microscope. The anastomotic site of the nerve was enveloped with gelatin sponge soaked with 5 mL of autologous peripheral blood mononuclear cell suspension. The remaining 10mL of cell suspension was used for a multi-point injection into the local muscles, 0.5 mL at each point. Thereafter, the deep fascia and the incision were sutured in sequence. Postoperative antibiotic treatment was used to prevent infection for 48 hours, and upper limb immobilization lasted for 4 weeks. Performance of rehabilitation exercise was guided. During the follow-up, wrist dorsal extension and muscle strength of extensor carpi ulnaris and extensor digitorum communis were detected to evaluate the therapeutic efficacy. RESULTS AND CONCLUSION: All the patients were followed up for 15 to 36 months, with an average of 17 months. Efficacy was excellent in 9 cases, good in 2 cases, fair in 1 case and poor in 0 case. The excellent and good rate was 92%. The wrist dorsal extension could achieve the functional needs, and the thumb dorsal extension and finger extension basically met the functional requirements. It is suggested that autologous peripheral blood mononuclear cell transplantation can achieve good outcomes in the treatment of high radial nerve injury.%背景:近年来神经干细胞、脂肪间充质干细胞、肌源性干细胞、诱导多能干细胞已应用于治疗周围神经损伤,但自体外周血单个核细胞应用于外周神经损伤的治疗鲜有报道.目的:观察自体外周血单个核细胞治疗高位桡神经离断伤的疗效.方法:自2011年4月至2015年9月,共收治上臂中段桡神经离断伤12例,术前动员外周血单个核细胞,手术当日提取外周血单个核细胞悬液15 mL,手术探查吻合桡神经,显微镜下行端端外膜缝合法吻合神经,用浸泡5 mL自体外周血单个核细胞悬液的凝胶海绵包裹神经吻合口,剩余10 mL外周血单个核细胞悬液行局部肌肉多点注射,每点注射0.5 mL,缝合深筋膜,常规缝合伤口.术后给予抗生素预防感染48 h,上肢制动4周,指导患者康复锻炼.随访观察腕关节背伸度数、伸腕伸指肌肌力,进行疗效评价.结果与结论:①术后患者均获随访,随访时间15-36个月,平均17个月;②综合评价:优9例,良2例,可1例,差0例,优良率为92%;③腕关节背伸均能够达到功能需要,拇指背伸、伸指基本满足功能要求;④结果提示,自体外周血单个核细胞移植治疗高位桡神经损伤效果满意.
    • 李建华; Zheng MX; Hua XY; Feng JT
    • 摘要: 痉挛性上肢瘫是脑血管意外或其他颅内病变患者长期并发症之一。这项研究评估了C7神经移植治疗痉挛性上肢瘫痪的疗效。实验纳入了脑卒中、脑外伤后偏瘫患者。在经过至少5年的康复治疗后,所有人的功能都已趋于稳定。实验组将对侧C7神经吻合到患侧,对照组未行手术,两组均予以相同康复治疗。一年后评估Fugl-Meyer上肢评分。
    • 刘鹏飞
    • 摘要: 舌下-面神经吻合术(HFA)是治疗周围性面瘫的常用术式,经典的端端吻合术式需切断舌下神经,而侧端吻合术在修复面神经功能的同时可最大程度保留同侧舌下神经的功能,有良好的应用前景.本文通过对面瘫的手术治疗现状、HFA术式演变和侧端吻合神经再生机制及临床应用现状进行综述,以期为进一步研究及临床应用提供参考.
    • 陈姚地; 李显; 鲁琦; 刘平; 李勇; 赵洪伟
    • 摘要: 目的 探讨副神经化上斜方肌肌皮瓣即刻修复舌鳞癌手术后舌体缺损的临床疗效.方法 收集2015年1月至2016年12月重庆医科大学附属口腔医院口腔颌面外科收治的6例经病理确诊的舌鳞癌患者,均行舌颈联合根治性颈清术,术中采用副神经和舌下神经吻合术的上斜方肌肌皮瓣同期修复舌缺损.供区创面直接拉拢缝合,未行植皮.结果 6例皮瓣全部成活.6个月至1年后,皮瓣呈现黏膜化,类似口腔黏膜形态,质地良好.再造舌的早期(3个月内)动度主要依靠残留舌体的运动.6个月后再造舌有明显动度,但灵活度较健侧差,患者对语言、吞咽等功能满意.结论 副神经化上斜方肌肌皮瓣是修复舌鳞癌术后缺损理想皮瓣之一.%Objective To explore the clinical effects of superior trapezius myocutaneous flap through accessory nerve anastomosis in immediately repairing the tongue defect after tongue squamous cell carcinoma operation.Methods Six cases of tongue squamous cell carcinoma diagnosed by pathology in the Maxillofacial Surgery Department of the Affiliated Stomatological Hospital of Chongqing Medical University from January 2015 to December 2016 were collected and Performed the tongue-neck combined radical operation.The superior trapezius myocutaneous flap simultaneous repair of tongue defect with accessory nerve and hypoglossal anastomosis was adopted during operation.The wound surface of donor site was directly sutured without skin grafting.Results All flaps survived.After 6 months to one year,the flap became mucolized,the surface of flap was similar to the normal oral mucosa with good character.The movement of reconstructed tongue mainly depended on the movement of residual tongue at early stage (within postoperative 3 months).After 6 monthsthe reconstructed tongue had obvious mobility,but the flexibility was poorer than that of the uninjured side,and the patient was satisfied with the language and swallowing function.Conclusion The superior trapezius myocutaneous flap through the accessory nerve anastomosis is one of the ideal skin flaps for repairing tongue defect after e tongue squamous cell carcinoma operation.
    • 马建军1; 何新泽2; 王浩琪1; 孙勃1; 高云峰1; 付士杰1; 王培1
    • 摘要: 背景:课题组前期研究发现创伤性脑损伤可促进周围神经损伤的修复再生,这可能与减少神经断端胶原瘢痕形成有关。目的:观察不同位置脑损伤对大鼠同一侧坐骨神经损伤后修复的影响。方法:将99只SD雄性大鼠,按照完全随机分组原则,分为单纯右侧坐骨神经损伤组(A组)、右侧坐骨神经损伤并右侧脑损伤组(B组)、右侧坐骨神经损并左侧脑损伤组(C组)。全部大鼠右侧坐骨神经完全切断,显微镜下吻合,B组同时采用Feeney方法建立右侧大脑皮质损伤模型,C组建立左侧大脑皮质损伤模型,于造模后4,6,8,10和12周各时间点踩足印并测量数值,计算坐骨神经功能指数;于造模后4,8和12周,取每组大鼠双侧腓肠肌,称湿质量并计算腓肠肌湿质量比;随后取右侧腓肠肌进行运动终板的乙酰胆碱酯酶染色,分析平均吸光度值;于造模后4,8和12周进行右侧坐骨神经处荧光金逆行示踪,示踪1周后取脊髓L4、L5节段做冰冻切片,荧光显微镜观察并计数被荧光金标记的脊髓前角运动神经元。结果与结论:①随时间延长,各组大鼠坐骨神经功能指数逐渐恢复,造模后4、6周时B和C组均优于A组(P0.05);自8周起,B组明显高于A和C组(P<0.05);③腓肠肌运动终板乙酰胆碱酯酶染色后,在造模后4周,3组间腓肠肌运动终板吸光度差异无显著性意义。自8周起B组吸光度值明显高于A和C组(P<0.05);④在造模后4周时,B组与C组的荧光金阳性脊髓前角运动神经元的数目均明显多于A组(P<0.05);12周时B组荧光金阳性神经元数量明显较A和C组多(P<0.05);⑤结果提示,伴有同侧脑损伤可促进大鼠坐骨神经损伤修复再生,这为进一步揭示创伤性脑损伤可促进周围神经损伤的具体机制提供理论依据。
    • 马建军; 何新泽; 王浩琪; 孙勃; 高云峰; 付士杰; 王培
    • 摘要: BACKGROUND:Previous studies have shown that traumatic brain injury can promote the regeneration of peripheral nerve by reducing scar collagen in nerve endings.OBJECTIVE:To investigate the effect of brain injury at different locations on the ipsilateral rat sciatic nerve regeneration.METHODS:Ninety-nine healthy male Sprague-Dawley rats were equivalently randomized into three groups:group A,right sciatic nerve transection;group B,right sciatic nerve transection combined with right brain injury;and group C,right sciatic nerve transection combined with left brain injury.All of transected nerves were sutured under microscope.Classical Feeney method was used to establish a model of traumatic brain injury.At 4,6,8,10 and 12 weeks after modeling,the sciatic functional index (SFI) was calculated by measuring footprint.At 4,8 and 12 weeks after modeling,the bilateral gastrocnemius were harvested for determining wet weight and calculate wet weight ratio,followed by acetylcholinesterase staining at the motor end plate to detect the absorbance values.At 4,8 and 12 weeks after modeling,fluoro-gold retrograde tracing was used to trace L4-5 vertebrae for 1 week,and the number of spinal cord anterior horn motor neurons positive for fluoro-gold was detected and calculated by fluorescence microscope.RESULTS AND CONCLUSION:The SFI value in each group was gradually improved with time.The SFI value was significantly higher in the groups B and C than the group A at 4 and 6 weeks after modeling (P < 0.05),and was further improved in the group B at 8 weeks compared with the groups A and C (P < 0.05).The wet weight ratio of gastrocnemius showed no significant difference among groups at 4 weeks after modeling (P > 0.05),and the group B showed a significantly higher wet weight ratio than the other groups from the 8th week (P < 0.05).Compared with the groups A and C,the absorbance values of motor endplate in group B appeared to be a significant increase at the beginning of the 8th week (P < 0.05).At 4 and 6 weeks after modeling,the number of spinal cord anterior horn motor neurons positive for fluoro-gold was significantly nigher in the groups B and C than in the group A,and the number was significantly higher in the group B than the groups A and C at 12 weeks (all P < 0.05).These finding manifest that brain injury can promote the repair of ipsilateral sciatic nerve injury,thus proving theoretical reference for unveiling the mechanism by which traumatic brain injury promotes peripheral nerve regeneration.%背景:课题组前期研究发现创伤性脑损伤可促进周围神经损伤的修复再生,这可能与减少神经断端胶原瘢痕形成有关.目的:观察不同位置脑损伤对大鼠同一侧坐骨神经损伤后修复的影响.方法:将99只SD雄性大鼠,按照完全随机分组原则,分为单纯右侧坐骨神经损伤组(A组)、右侧坐骨神经损伤并右侧脑损伤组(B组)、右侧坐骨神经损并左侧脑损伤组(C组).全部大鼠右侧坐骨神经完全切断,显微镜下吻合,B组同时采用Feeney方法建立右侧大脑皮质损伤模型,C组建立左侧大脑皮质损伤模型,于造模后4,6,8,10和12周各时间点踩足印并测量数值,计算坐骨神经功能指数;于造模后4,8和12周,取每组大鼠双侧腓肠肌,称湿质量并计算腓肠肌湿质量比;随后取右侧腓肠肌进行运动终板的乙酰胆碱酯酶染色,分析平均吸光度值;于造模后4,8和12周进行右侧坐骨神经处荧光金逆行示踪,示踪1周后取脊髓L4、L5节段做冰冻切片,荧光显微镜观察并计数被荧光金标记的脊髓前角运动神经元.结果与结论:①随时间延长,各组大鼠坐骨神经功能指数逐渐恢复,造模后4、6周时B和C组均优于A组(P<0.05);自8周起,B组坐骨神经功能指数恢复明显优于A组与C组(P<0.05);②在造模后4周,3组大鼠的腓肠肌湿质量比无明显差异(P>0.05);自8周起,B组明显高于A和C组(P<0.05);③腓肠肌运动终板乙酰胆碱酯酶染色后,在造模后4周,3组间腓肠肌运动终板吸光度差异无显著性意义.自8周起B组吸光度值明显高于A和C组(P<0.05);④在造模后4周时,B组与C组的荧光金阳性脊髓前角运动神经元的数目均明显多于A组(P< 0.05);12周时B组荧光金阳性神经元数量明显较A和C组多(P<0.05);⑤结果提示,伴有同侧脑损伤可促进大鼠坐骨神经损伤修复再生,这为进一步揭示创伤性脑损伤可促进周围神经损伤的具体机制提供理论依据.
    • 马瑞峰; 孙鹏
    • 摘要: 目的 比较不同神经吻合方式修复双侧指固有神经缺损的临床疗效.方法 选择70例双侧指固有神经缺损患者按照不同神经吻合方式分成A、B、C3组:A组24例采用移植神经弓端侧吻合,B组26例采用移植神经弓双端侧吻合,C组20例采用移植神经直接桥接端端吻合.观察3组指关节自主活动度总和(TAM)、感觉恢复情况、两点辨别觉和不良反应发生情况.结果 患者均获得随访,时间1~ 10个月.3组指关节TAM优良率比较差异无统计学意义(P>0.05).A组和B组远节指腹感觉明显高于C组(P<0.05),A、B两组比较差异无统计学意义(P>0.05).A组和B组两点辨别觉明显低于C组(P<0.05),A、B两组比较差异无统计学意义(P>0.05).3组患者伤口均甲级愈合,未出现伤口感染和皮肤软组织坏死.术后72 h出现血管危象A组1例、B组2例、C组1例,均在肌肉注射盐酸哌替啶+静脉滴注肝素钠后缓解.B组2例术后4~6周用力握物时出现麻木和放射性疼痛等,术后6~12周疼痛自行消失.结论 移植神经弓端侧吻合能够有效修复双侧指固有神经缺损,促进指腹感觉的恢复,效果优于移植神经直接桥接端端吻合.
    • 李俊; 陈燕; 金红旭
    • 摘要: 目的:对比吻合神经的逆行指背筋膜皮瓣、指动脉逆行岛状皮瓣的临床效果,为临床选择更理想的术式.方法:选取55例(62指)指端缺损患者,根据伤情分为吻合神经的逆行指背筋膜皮瓣组29例(A组32指)、指动脉逆行岛状皮瓣组26例(B组30指)进行手术修复.术后均随访12个月,分析比较血供状态、愈合情况及手指功能.结果:两组患指皮瓣均存活,外观较理想.B组术后创口愈合时间短于A组(P<0.05);A组血液循环状态优良率、近侧指间关节(PIP)活动度及感觉恢复功能优于B组(P<0.05).皮瓣血管危象发生率、远侧指间关节(DIP)活动度及皮瓣两点辨别觉组间无明显差异(P>0.05).结论:与指动脉逆行岛状皮瓣相比,吻合神经的逆行指背筋膜皮瓣在患指功能恢复方面效果更理想.
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