摘要:
Objective:To study the correlation of serum angiogenin 2 (Ang-2) level with neurohumor indexes and myocardial remodeling indexes in patients with chronic heart failure.Methods:The patients with chronic heart failure who were treated in the People's Hospital of Huangmei between March 2015 and October 2017 were selected and divided into NYHA Ⅰ-Ⅱ group and NYHA Ⅲ-Ⅳ group according to cardiac function classification;healthy subjects who received physical examination during the same period were selected as the control group.The levels of Ang-2,neurohumor indexes and myocardial remodeling indexes in serum were determined.Results:Serum Ang-2,NT-proBNP,Copeptin,ET-1,AT-Ⅱ,ALD,FGF23,TGFβ1,Gal-3,PICP and ICTP levels of NYHA Ⅰ-Ⅱ group and NYHA Ⅲ-Ⅳ group were significantly higher than those of control group whereas TIMP4 levels were significantly lower than that of control group;serum Ang-2,NT-proBNP,Copeptin,ET-1,AT-Ⅱ,ALD,FGF23,TGFβ1,Gal-3,PICP and ICTP levels of NYHA Ⅲ-Ⅳ group were significantly higher than those of NYHA Ⅰ-Ⅱ group whereas TIMP4 level was significantly lower than that of NYHA Ⅰ-Ⅱ group.Serum NT-proBNP,Copeptin,ET-1,AT-Ⅱ,ALD,FGF23,TGFβ1,Gal-3,PICP and ICTP levels in chronic heart failure patients with high Ang2 level were significantly higher than those in chronic heart failure patients with low Ang-2 level whereas TIMP4 level was significantly lower than that in chronic heart failure patients with low Ang-2 level.Conclusion:The increase of Ang-2 in patients with chronic heart failure is related to neurohumoral disorder and myocardial remodeling aggravation.%目的:研究慢性心衰患者血清血管生成素2(Ang-2)含量与神经体液指标、心肌重构指标的相关性.方法:选择黄梅县人民医院2015年3月~2017年10月期间收治的慢性心衰患者,根据心功能分级分为NYHA Ⅰ-Ⅱ组、NYHA Ⅲ-Ⅳ组;另取同期体检的健康者作为对照组.测定血清中Ang-2、神经体液指标、心肌重构指标的含量.结果:NYHA Ⅰ-Ⅱ组、NYHA Ⅲ-Ⅳ组患者血清中Ang-2、NT-proBNP、Copeptin、ET-1、AT-Ⅱ、ALD、FGF23、TGFβ1、Gal-3、PICP、ICTP的含量显著高于对照组,TIMP4的含量显著低于对照组;NYHA Ⅲ-Ⅳ组患者血清中Ang-2、NT-proBNP、Copeptin、ET-1、AT-Ⅱ、ALD、FGF23、TGFβ1、Gal-3、PICP、ICTP的含量显著高于NYHA Ⅰ-Ⅱ组患者,TIMP4的含量显著低于NYHA Ⅰ-Ⅱ组患者.Ang-2高含量的慢性心衰患者血清中NT-proBNP、Copeptin、ET-1、AT-Ⅱ、ALD、FGF23、TGFβ1、Gal-3、PICP、ICTP的含量显著高于Ang-2低含量的慢性心衰患者,TIMP4的含量显著低于Ang-2低含量的慢性心衰患者.结论:慢性心衰患者血清Ang-2含量的升高与神经体液紊乱、心肌重构加剧有关.