活血祛瘀剂/治疗应用

活血祛瘀剂/治疗应用的相关文献在2000年到2019年内共计1475篇,主要集中在中国医学、内科学、外科学 等领域,其中期刊论文1474篇、会议论文1篇、专利文献1662683篇;相关期刊18种,包括健康必读·新医学导刊、中国保健营养(中旬刊)、河北中医等; 相关会议1种,包括中华中医药学会血栓病分会第四次学术研讨会暨广东省中医药学会血栓病专业委员会首届学术研讨会等;活血祛瘀剂/治疗应用的相关文献由2954位作者贡献,包括李军、张莉、张青等。

活血祛瘀剂/治疗应用—发文量

期刊论文>

论文:1474 占比:0.09%

会议论文>

论文:1 占比:0.00%

专利文献>

论文:1662683 占比:99.91%

总计:1664158篇

活血祛瘀剂/治疗应用—发文趋势图

活血祛瘀剂/治疗应用

-研究学者

  • 李军
  • 张莉
  • 张青
  • 李联社
  • 赵立新
  • 于小勇
  • 张玲
  • 李敏
  • 熊佩华
  • 荣培红
  • 期刊论文
  • 会议论文
  • 专利文献

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    • 邓彬; 李志峰; 聂启; 胡洪涛; 王晓占; 甘泉
    • 摘要: [目的]探讨参附注射液联合血必净注射液治疗脓毒症急性肾损伤(AKI)对患者肾功能和血流动力学水平的影响.[方法]116例脓毒症AKI患者分为两组.对照组采用血必净注射液治疗,观察组采用参附注射液联合血必净注射液治疗,比较两组患者治疗后的疗效.[结果]两组患者治疗前巨噬细胞炎症蛋白-2 (MIP-2)、血管紧张素Ⅰ (Ang Ⅰ)、尿肾损伤分子-1(KIM-1)、人中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、肾功能、肾动脉血流动力学水平组间比较差异无显著性(P>0.05).观察组患者治疗后MIP-2、Ang Ⅰ、KIM-1、NGAL、血肌酐(SCr)、血尿素氮(BUN)、胱抑素(Cys-C)水平低于对照组,肾动脉收缩期峰值血流速度(Vp)、舒张期最小血流速度(Vd)、平均血流速度(Vm)水平高于对照组(P<0.05).两组患者治疗前急性生理与慢性健康状况评分系统Ⅱ(APACHEⅡ)、多器官功能障碍评分系统(Marshall)评分组间比较差异无显著性(P>0.05);观察组治疗后APACHEⅡ、Marshall评分低于对照组(P<0.05).[结论]参附注射液联合血必净注射液治疗脓毒症AKI,可降低MIP-2、Ang Ⅰ、KIM-1、NGAL水平,改善患者的肾功能及肾动脉血流动力学.
    • 付强; 齐霁
    • 摘要: [Objective]To investigate the therapeutic effect of Gu Hong Injection on angina pectoris after percutaneous coronary intervention (PCI) in patients with coronary heart disease and its influence on inflammatory reaction and vascular endothelial function.[Methods]From January 2014 to December 2016,114 patients with angina pectoris treated by PCI operation in our hospital were selected.According to the random number method;they were divided into observation group and control group with 57 cases in each group.Patients in the control group were treated with aspirin enteric-coated tablets,clopidogrel sulfate tablets,isosorbide mononitrate tablets and metoprolol tartrate tablets.The observation group was treated with Gu Hong Injection on the basis of the use of the control group.All the patients were treated for 2 weeks.The frequency and duration of angina pectoris before and after treatment were compared between the two groups.The therapeutic effect of angina pectoris was evaluated.Levels of serum Hs-CRP,tumor necrosis factor-α (TNF-a),interleukin-6 (IL-6) and endothelin-1 (ET-1) and nitric oxide (no) were compared between the two groups before and after treatment.At the same time,Doppler color ultrasound was used to evaluate vascular endothelium-dependent diastolic (FMD) function.[Results] After treatment,the attack frequency and duration of angina pectoris in the two groups were lower than those before treatment,and the attack frequency and duration of angina pectoris in the observation group were significantly lower than those in the control group.The difference was statistically significant (P <0.05).The total effective rate of treatment in the observation group was 91.2 % (52/ 57),which was significantly higher than that in the control group 82.5% (47/ 57),and the difference was statistically significant (x2 =5.368,P <0.05).After treatment,the levels of serum Hs-CRP,TNF-and IL-6 were significantly decreased in both groups.The level of serum Hs-CRP,TNF-and IL-6 in the observation group was significantly lower than that in the control group (P <0.05).After treatment,the serum ET-1 level in the two groups was significantly decreased,the levels of NO and FMD increased significantly;the serum ET-1 level in the observation group was significantly lower than that in the control group.The NO and FMD were significantly higher than those of the control group,the difference was statistically significant (P <0.05).[Conclusion]On the basis of routine treatment after PCI operation for coronary heart disease,Guhong injection significantly reduce the frequency of recurrent angina pectoris after PCI and the level of serum inflammatory factors,and improve vascular endothelial function.%[目的]探讨谷红注射液辅助治疗冠心病患者经皮冠脉动脉介入术(PCI)术后再发心绞痛的临床疗效及其对患者炎性因子水平和血管内皮功能的影响.[方法]选择2014年1月至2016年12月本院收治的114例行PCI治疗后复发心绞痛的冠心病患者,根据随机数表法将其分为观察组和对照组,每组各57例.对照组患者给予阿司匹林肠溶片、硫酸氢氯吡格雷片、单硝酸异山梨酯片、酒石酸美托洛尔片治疗,观察组在对照组用药的基础上给予谷红注射液治疗,所有患者均治疗2周.比较两组患者治疗前后的心绞痛发生频率和持续时间,并对患者心绞痛症状的治疗效果进行评价,比较两组患者治疗前后血清高敏C反应蛋白(Hs-CRP)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、内皮素-1(ET-1)、一氧化氮(N())水平.同时应用多普勒彩色超声对患者血管内皮依赖性舒张功能(FMD)进行评价.[结果]两组治疗后心绞痛的发作频率及持续时间均低于治疗前,观察组治疗后心绞痛发作频率及持续时间均明显低于对照组,差异均具有统计学意义(P<0.05).观察组治疗的总有效率为91.2%(52/57)显著高于对照组的82.5%(47/57),差异具有统计学意义(x2=5.368,P<0.05).治疗后,两组患者血清Hs-CRP、TNF-α及IL-6水平均显著降低,观察组治疗后血清Hs-CRP、TNF-α、IL-6水平显著低于对照组,差异均具有统计学意义(P<0.05).治疗后,两组血清ET-1水平显著降低,NO、FMD水平显著升高,观察组血清ET-1水平显著低于对照组,NO、FMD显著高于对照组,差异均具有统计学意义(P<0.05).[结论]在冠心病PCI术后常规治疗的基础上,谷红注射液明显减少冠心痛PCI术后再发心绞痛频率并能够显著降低患者血清炎症因子水平,改善血管内皮功能.
    • 朱玲; 尹璐; 陶睿
    • 摘要: 目的:研究自拟眩清汤治疗痰瘀阻络型慢性脑供血不足临床疗效,为临床提供参考.方法:选取100例痰瘀阻络型慢性脑供血不足患者作为研究对象,根据随机数表法分为对照组、研究组,各50例.对照组患者采用银杏叶片治疗,研究组患者采用自拟眩清汤治疗.治疗2个月后,比较两组患者治疗前后中医症候积分、血清hs-CRP、脂蛋白a水平变化及临床疗效、不良反应发生率.结果:治疗2个月后,两组患者的中医症候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P0.05).结论:采用自拟眩清汤治疗痰瘀阻络型慢性脑供血不足疗效显著,安全性高,能有效缓解临床症状与体征,减轻炎性反应,调节脂质代谢水平,值得临床应用.%Objective:To study the clinical efficacy of self made Xuan Qing soup in the treatment of chronic cerebral circulation insufficiency with phlegm and blood stasis obstructing collaterals,and to provide reference for clinical treatment.Methods:100 cases of patients with chronic cerebral circulation insufficiency of blood stasis and phlegm as the research object,according to randomly divided into control group and study group,50 cases in each.Patients in the control group were treated with Ginkgo Biloba leaves extract tablets,and patients in the study group were treated with Xuan Qing soup.After 2 months of treatment,the TCM syndrome scores,serum hs-CRP,lipo-protein a levels,clinical efficacy and adverse reaction rate were compared between the two groups before and after treatment.Results:After 2 months of treatment,the TCM syndrome score of the two groups of patients were lower than those before treatment,and the study group than in the control group,the difference was statistically signifi-cant (P0.05).Conclusion:The treatment of chronic cerebral circulation insufficiency of phlegm and blood stasis collateral type with self made Xuan Qing soup has remarkable curative effect,high safety,can effective-ly relieve the clinical symptoms and signs,reduce inflammatory response and regulate the level of lipid metabolism,so it is worthy of clinical application.
    • 郝青松
    • 摘要: 目的:观察分析化瘀疏通方对气虚血瘀型脑梗死患者脑血流灌注量及神经功能的影响.方法:选取94例气虚血瘀型脑梗死患者,按随机数字表法分为治疗组与对照组各47例,对照组患者入院后给予西医常规治疗,治疗组在对照组的基础上加上化瘀疏通方联合进行治疗.回顾性分析两组患者的临床资料,比较分析两组患者治疗前后血流灌注量、神经功能的变化及临床疗效.结果:治疗后,治疗组神经功能缺损评分明显低于对照组(P<0.05).治疗后,治疗组脑血流灌注量明显高于对照组(P<0.05).治疗后,治疗组有效率(95.74%)明显高于对照组(72.34%)(P<0.05).结论:化瘀疏通方治疗气虚血瘀型脑梗死患者相比常规西药治疗临床疗效更显著,降低神经功能缺损程度评分,提高脑血流灌注量,改善患者生活质量,有利于患者病情快速恢复.%Objective:To observe and analyze the effect of Huayu Shutong recipe on cerebral blood perfusion and neurological function in patients with cerebral infarction with difficiency of Qi and blood stasis.Methods:94 pa-tients with cerebral infarction of Qi deficiency and blood stasis were randomly divided into treatment group and con-trol group with 47 cases in each group.The control group was given routine western medicine treatment after admis-sion,and the treatment group was treated with Huayu Shutong recipe on the basis of the control group.The clinical data of two groups were retrospectively analyzed.The changes of blood perfusion,neurological function and clinical efficacy were compared between the two groups before and after treatment.Results:After treatment,the neurologi-cal deficit scores in the treatment group were significantly lower than those in the control group (P<0.05);The cerebral blood perfusion in the treatment group was significantly higher than that in the control group (P<0.05);And the effective rate of the treatment group was 95.74%,which was significantly higher than 72.34% of the con-trol group (P<0.05).Conclusion:Compared with conventional Western medicine treatment,Huayu Shutong Reci-pe is a more effective way in reducing the degree of neurological deficit score,improving cerebral blood perfusion and patient quality of life for patients with cerebral infarction with difficiency of Qi and blood stasis.
    • 张玉龙
    • 摘要: 目的:观察平肺化瘀汤联合阿司匹林对慢性阻塞性肺疾病(COPD)合并继发性红细胞增多症患者凝血功能、呼吸功能和运动耐量的影响.方法:将90例COPD合并继发性红细胞增多症患者随机分为两组,每组45例,两组均给予常规基础治疗,对照组在其基础上给予阿司匹林,观察组在对照组基础上给予自拟平肺化瘀汤治疗,疗程8周.观察两组治疗前后血液学、凝血功能、呼吸功能和运动耐力的变化情况.结果:两组治疗后RBC、Hb、EPO、Hct显著降低,观察组EPO、Hct低于对照组(P<0.05);两组治疗后APTT、Fib显著降低,观察组上述指标均低于对照组(P<0.05);两组治疗后FEV1/FVC、峰值呼吸流速(PEF)、肺一氧化碳弥散量(DLCO)均显著升高,观察组均高于对照组(P<0.05);两组治疗后6min步行试验距离(6M WD)分级和距离均显著提高,观察组的改善情况优于对照组(P<0.05).结论:自拟平肺化瘀汤联合阿司匹林可显著降低COPD合并继发性红细胞增多症患者RBC、Hb、EPO、Hct,降低高凝状态,改善微循环和呼吸功能,从而提高运动耐量.%Objective:To observe the effect of Pingfei Huayu soup in combination with aspirin on coagulation function,respiratory function and exercise tolerance of chronic obstructive pulmonary disease (COPD) patients with secondary polycythemia.Methods:90 cases of COPD patients with secondary polycythemia were randomly divided into two groups with 45 cases in each,both groups received conventional treatments,control group received aspirin on the basis of routine treatment meanwhile observation group received Pingfei Huayu soup combined with aspirin for 8 weeks.Haematological indexes,coagulation function,respiratory function and exercise tolerance were ob-served in both groups before and after treatment.Results:RBC,Hb,EPO and Hct after treatment were markedly decreased in both groups,EPO and Hct of observation group were lower than those of control group (P<0.05),APTT and Fib after treatment were significantly decreased as compared with those before treatment in both groups (P<0.05),those indexes in observation group were lower than those in the control group (P<0.05).FEV1/FVC,peak expiratory flow (PEF) and diffusing capacity of the lungs for carbon monoxide (DLCO ) after treatment in both groups were significantly higher than those before treatment,and these indexes in observation group were higher than the control group (P<0.05).classification and distance of 6-minute walking distance (6MWD) test were significant-ly improved after the treatment in both goups,and improvement of observation group was obviously better than the control group (P<0.05).Conclusion:The treatment of Pingfeihuayu soup combined with aspirin can significantly reduce RBC,Hb,EPO,Hct of COPD patients with secondary erythrocytosis,and reduce high coagulation state,im-prove microcirculation and respiratory function,so as to improve exercise tolerance.
    • 侯利红; 白莹
    • 摘要: Objective:To investigate the effect of activating blood circulation and removing phlegm method on the rehabilitation function of patients with cerebral infarction.Methods:One hundred and eighty patients with cere-bral infarction were enrolled in this study.They were equally divided into two groups according to the order of the patients,with 54 patients in each group.In the control group,the study group was treated with qi and activating blood circulation and resolving phlegm by oral administration of traditional Chinese medicine for 8 weeks.After 8 weeks,the therapeutic effect,hemodynamics,quality of life and other indicators were observed.Results:The cura-tive effect,the control group,the basic cure rate of 29.63%,the total effective rate of 77.78%,the study group,the basic cure rate was 38.89%,the total effective rate of 88.89%,the study group of the basic cure rate,the total effective rate was significantly better than the control group (P<0.05).Compared with before treatment,NHISS significantly decreased in both groups,but significantly increased in ADL,FMA,self -efficacy and quality of life in-dicators,before and after treatment (P<0.05) (P<0.05).The mean blood viscosity,blood viscosity,erythrocyte area,erythrocyte aggregation index,plasma protein C and plasma protein S were significantly increased in both groups before and after treatment (P<0.05) The study group above the end of the index were significantly better than the control group (P<0.05).Conclusion:The combination of qi and activating blood circulation and resolving phlegm can improve neurological function,improve quality of life,improve curative effect and promote blood circula-tion in cerebral infarction.%目的:探讨活血化痰行气法联合西药对脑梗死患者康复功能影响性.方法:选取108例脑梗死患者为研究对象,按入组先后顺序平均分成两组,每组为54例.对照组西药治疗,研究组加用活血化痰行气法中药口服,连续治疗8周,8周后观察不同方法治疗后在疗效、血液动力学、生活质量等指标影响性.结果:疗效上,对照组基本痊愈率29.63% 、总有效率77.78%,研究组基本痊愈率38.89% 、总有效率88.89%,研究组基本痊愈率、总有效率显著优于对照组(P<0.05);两组治疗末N HISS较治疗前显著下降,而在ADL、FM A、自我效能、生活质量指标上比较则显著升高,治疗前末比较差异显著(P<0.05),研究组治疗末以上指标均显著优于对照组(P<0.05);两组治疗末量血黏度、血液黏度、红细胞面积、红细胞聚集指数、血浆蛋白C、血浆蛋白S含量水平均显著治疗前(P<0.05),研究组治疗末以上指标均显著优于对照组(P<0.05).结论:活血化痰行气法联合西药能改善脑梗死神经功能,改善生活质量,提高疗效,促进血液循环.
    • 张斌剑
    • 摘要: 目的:探讨中药汤剂辅助闭合复位股骨近端防旋髓内钉(PFN-A)微创内固定术治疗老年闭合性股骨转子间骨折的临床效果.方法:将116例老年闭合性股骨转子间骨折患者均分为两组,其中对照组患者接受闭合复位PFN-A微创内固定治疗,观察组患者在对照组手术治疗基础上加服中药汤剂持续治疗4周.观察这两组患者患侧肿胀消除时间、卧床时间、骨性愈合时间、下地负重时间、Harris评分及短期并发症发生情况;记录两组患者术后2 d和术后30 d时机体血红蛋白(Hb)、隐性失血量(V失血)、血钙及血清碱性磷酸酶(AKP)水平变化情况.结果:与对照组相比,观察组患者患侧肿胀消退时间、卧床时间、骨性愈合时间及下地负重时间均明显缩短,Harris评分明显提高,术后短期并发症发生率明显降低,差异具有统计学意义(P0.05).与术后2 d时相比,对照组患者术后30 d时体内上述指标均未发生明显变化,差异无统计学意义(P>0.05);而观察组患者体内Hb含量明显增加,V失血明显减少,血钙及血清AKP水平均明显升高,且术后30 d时,观察组患者Hb、V失血及血清AKP水平均优于同时期对照组患者水平,差异具有统计学意义(P<0.05).结论:中药汤剂可显著改善股骨转子间骨折患者围术期隐性失血状况,促进骨组织钙化,减少术后并发症,提高治疗效率.
    • 李跃京; 刘锋伟; 李彦州; 赵敏; 韩松辉
    • 摘要: 目的:观察艽活四物汤联合介入疗法治疗骨质疏松性椎体压缩性骨折的疗效及对骨代谢的影响.方法:将92例骨质疏松性椎体压缩性骨折患者随机分为观察组(45例)和对照组(47例) ,对照组接受经皮穿刺椎体成形术(PVP) ,术后给予标准抗骨质疏松三联疗法治疗;观察组在对照组的基础上给予艽活四物汤治疗,疗程12周.观察两组临床预后和骨代谢变化情况.并统计临床疗效.结果:两组治疗后疼痛视觉模拟法评分(VAS)、椎体前壁高度(AVBH)、椎体后凸角度(Cobb)、骨密度(BMD)均有显著改善,观察组以上指标改善情况优于对照组(P均<0 .05) ;两组治疗后Oswestry功能障碍指数(ODI)、Barthel指数(BI)和世界卫生组织生存质量测定量表(WHO-QOL-100)总分均显著改善,观察组以上指标的改善情况均优于对照组(P均<0 .05) ;两组治疗后血清骨钙素(BGP)、碱性磷酸酶(ALP)、骨保护素(OPG)水平显著升高,I型胶原交联羧基末端肽(CTX-I)显著降低,观察组以上指标均优于对照组(P均<0 .05) ;观察组临床疗效优于对照组(P<0 .05) .结论:艽活四物汤联合介入疗法治疗骨质疏松性椎体压缩性骨折疗效满意,不仅缓解疼痛,促进椎体形态和功能恢复,还提高了日常生活能力和生活质量,其机制之一可能与其改善骨代谢有关.
    • 冯华国; 代国华; 冯毅; 鲁灵
    • 摘要: 目的 探讨血必净注射液治疗急性梗阻性化脓性胆管炎老年患者的临床应用价值及可能作用机制.方法 选取2011年9月至2016年3月该院肝胆外科住院接受急诊开腹手术、经内镜逆行胰胆管造影(ERCP)或经皮肝穿刺胆道引流(PTCD)术的急性梗阻性化脓性胆管炎老年患者(年龄大于或等于60岁)60例,随机分为治疗组和对照组,每组30例.2组患者均给予常规急诊手术或急诊ERCP或PTCD治疗,治疗组在此基础上静脉滴注血必净注射液50 mL,每天2次,连用7 d.分别检测2组患者治疗前后凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(Fg)、血小板计数(Plt)等凝血指标,并同时检测降钙素原(PCT)及C-反应蛋白(CRP),并记录2组患者术后住院时间及病死率,统计分析2组患者相关指标的差异.结果 2组患者治疗7d后凝血功能较治疗前均有所好转,且治疗组患者PT[(13.29±4.29)s]、APTT[(36.80±8.27)s]、CRP[(23.54±23.21)mg/L]、PCT[(1.62±4.03)ng/mL]均明显低于对照组[分别为(16.29±4.29)s、(39.08±7.26)s、(45.01±19.56)mg/L、(6.23±3.26)ng/mL],Fg(3.38±0.82)g/L、Plt[(115.87±39.51)×109 L-1]均明显高于对照组[分别为(2.71±0.19)g/L、(80.36±40.23)×109 L-1],差异常均有统计学意义(P<0.05).2组患者中各死亡1例,病死率均为3.33%(1/30).结论 血必净注射液能改善急性梗阻性化脓性胆管老年患者的凝血功能,明显提高疗效,改善患者预后.
    • 舒畅
    • 摘要: [目的]探讨加用血必净对急诊急性百草枯中毒患者肾损伤的保护作用.[方法]将本院收治的86例急诊急性百草枯中毒患者随机分为两组,各43例,两组患者均实施急诊常规处理,观察组在对照组基础上另加用血必净治疗.比较治疗前后两组血清细胞因子[白细胞介素-6(IL-6)、血清肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]、氧化应激指标[血浆丙二醛(MDA)、超氧化物歧化酶(SOD)]、肾功能指标[内生肌酐清除率(Ccr)、血尿素氮(BUN)]的变化及疗效.[结果]治疗前两组各项指标相比较差异无显著性(P>0.05);治疗后两组IL-6、TNF-α、CRP、MDA、BUN较治疗前明显降低,而SOD、Ccr明显升高,且观察组改变幅度较对照组明显,其差异有显著性(P<0.05);观察组治疗后1个月随访存活率明显高于对照组(P<0.05).[结论]急诊百草枯中毒患者在常规治疗基础上加用血必净注射液,可通过有效调节患者炎症反应及氧化应激反应,达到保护肾功能的目的,从而有效改善预后提高存活率.
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