Clinical

摘要： Potential causes for the clinical and pathological variability observed in Alzheimer’s disease(AD):AD is an age-related neurodegenerative disorder characterized by the impairment of cognitive functions such as memory,learning,and reasoning.These commonly described clinical symptoms are due to particular pathological changes in the brain,including inflammation,synaptic loss,and neuronal death.These changes are a consequence of the accumulation of abnormally folded amyloid-β(Aβ)and tau proteins in specific areas of the central nervous system.Considering the progressive aging of the world’s population,the number of people affected by AD is expected to substantially and consistently increase in the coming years.This positions AD as one of the main public health challenges in the near future.

摘要： In recent years,large animal models of naturally occurring diseases have become increasingly studied,with the rationale that their disease attributes may better recapitulate the pathological features of corresponding human diseases as compared to induced disease models(Hoffman and Dow,2016).Of the available naturally occurring disease models,the canine is increasingly recognized as a valuable pre-clinical animal model in translational medicine for numerous human diseases,including cancer.

摘要： Parkinson's disease(PD)is the most frequent movement disorder and the second most prevalent age-related neurodegenerative disease(ND)worldwide.From the clinical point of view,it is characterized by severe motor complications,including uncontrollable resting tremors,rigidity,bradykinesia,and postural instability.

摘要： Epigenetic dysregulation is a key factor leading to oncogenesis and tumor progression1. To date, seven agents in three epigenetic target classes have been approved by the U.S. Food and Drug Administration for the treatment of diverse malignancies. Despite this approval for clinical application, the mechanisms of many epigenetic modulators are not completely understood, because many genes are epigenetically regulated.

摘要： Radiologic imaging is a diagnostic tool that greatly affects patient outcomes,[1]and with the recent development of imaging technology,advanced imaging tests such as computed tomography(CT)have gained widespread accessibility in hospitals.In particular,CT is essential in the evaluation of patients in low-level emergency departments(EDs)because of its ability to answer clinical questions accurately and quickly.[2]

摘要： Coronavirus disease 2019(COVID-19)has inarguably caused the most challenging pandemic.In less than 2 years,greater than 200 million cases of COVID-19 and 4.5 million deaths have been reported worldwide[1].The treatment strategy of an emerging infectious disease is a huge challenge for clinical practitioners because of missing key knowledge about the disease.

摘要： Dear Researchers,Journal of Clinical and Nursing Research(JCNR)is an international,peer reviewed and open access journal that seeks to promote the development and exchange of knowledge which is directly relevant to all clinical and nursing research and practice.Articles which explore the meaning,prevention,treatment,outcome and impact of a high standard clinical and nursing practice and discipline are encouraged to be submitted as original article,review,case report,short communication and letters.

摘要： Admission hyperglycemia is an independent predictor,that contributes to hemorrhagic transformation (HT),and worsened functional outcome following reperfusion therapy with tissue plasminogen activator (tPA) in ischemic stroke.Clinical studies have revealed a strong association between hyperglycemia and incidence of HT independent of prior diabetes diagnosis (Alvarez-Sabin et al.

摘要： Dear editor,The neck is rich in blood vessels.Abnormal origins are rarely seen in clinical practice,but some are found accidentally during relevant imaging examinations,autopsy,and surgery.Abnormal neck vessels are mostly asymptomatic;however,approximately 10%of patients with abnormal blood vessels may have clinical manifestations due to the compression of adjacent tissues and organs.

摘要： INTRODUCTION: The objective of our study was to determine the epidemiological clinical and histological aspects of gynecological and breast cancers in Pointe-Noire. PATIENTS AND METHODS: This was a retrospective descriptive study that took place in the cancerology and internal medicine department during the period from January 1, 2012 to December 31, 2021, i.e. a period of 10 years. Women with histological diagnosis of gynecological and breast cancers were included in our study. The variables studied were: frequency, age, alcohol and tobacco consumption, histological type, stage of extension, location of cancer. Bivariate analysis was done between age and location of the tumour. The statistical test used was the KHI2 test. The results were statistically significant for a value of p RESULTS: We collected 400 files from women with cancer. Among the 400 files, 265 were represented by gynecological and breast cancers, that is a frequency of 65.43%. Among the 265 cases of gynecological and breast cancer identified during this study period, breast cancer represented the first rank with 52% frequency. Cervical cancer accounted for 41% followed by ovarian cancer (5%) and endometrial (2%). Cancer of vulva was represented by a single case. The average age of patients with gynecological and breast cancers during our study was 52 ± 12 years. The average age of patients with cancer of the breast, cervix, ovarian, endometrial was respectively 49 ± 11.97 years, 54.73 ± 12.91 years old, 50 ± 14 years, 67 ± 14.24 years, the age of the vulva cancer patient was 51 years old. The histological type of breast cancer was represented by infiltrating ductal adenocarcinoma in 91% of cases, invasive lobular carcinoma in 7% and sarcoma in 2%. Cervical cancers were represented by squamous cell carcinomas in 95% of cases and adenocarcinomas in 5% of cases. Vulva cancer was represented by squamous cell carcinoma, ovarian cancer was represented by epithelial tumors (adenocarcinoma) in 100% of cases. Endometrial cancers were represented by endometrial adenocarcinoma. All cancers were diagnosed at advanced stages (locoregional and metastatic stage). Patients over the age of 50 had more gynecological and breast cancers;but this result was not significant. CONCLUSION: Gynecological and breast cancers are frequent and constitute the first cancer of Congolese women in Pointe-Noire. Breast cancer is the first cancer followed by cancer of the cervix and ovaries. The histological types are those of the literature. Patients with gynecological and breast cancers consult at very advanced stages.