摘要:
目的 观察并分析周小剂量卡铂(CBP)联合低剂量氟脲嘧啶治疗高龄晚期结肠癌患者的临床疗效和安全性.方法 将晚期结肠癌患者随机分为2组,A组采用周小剂量卡铂联合低剂量氟尿嘧啶治疗,B组采用顺铂联合低剂量氟尿嘧啶进行治疗,观察并比较其有效率、不良反应发生率、近期远期生存率.结果 A组完全缓解率25.0%,部分缓解率45.0%,总有效率达70.0%,明显高于B组,差异有统计学意义(P<0.05).A组发热者占7.5%,胃肠道反应者占10.0%,肝功能损伤者占10.0%,白细胞减少者占12.5%,均低于B组,差异有统计学意义(P<0.05).A组6个月生存率95.0%,1年生存率75.0%,1年半生存率50.0%,2年生存率40.0%,均高于B组,差异有统计学意义(P<0.05).结论 采用周小剂量卡铂联合低剂量氟尿嘧啶治疗晚期结肠癌,能明显提高治疗有效率,提高患者近期、远期生存率,不良反应发生率低,安全有效.%Objective To observe and analyze the clinical efficacy and safety of weekly low-dose carboplatin combined with low dose of fluoride urea pyrimidine for elderly patients with advanced colon cancer.Methods Advanced colon cancer pa-tients were randomly divided into 2 groups,group A received weekly low-dose carboplatin combined with low dose of fluoride urea pyrimidine,group B received cisplatin combined with low dose of fluoride urea pyrimidine ,the effectiveness,incidence of adverse reactions,short-term and long-term survival rates of the 2 groups were observed and compared.Results In group A,complete re-mission was 25.0%,partial response was 45.0%,total effective rate was 70.0%,which were significantly higher than those of group B(P<0.05);Fever in group A was 7.5%,gastrointestinal tract reaction was 10.0%,liver function injury was 10.0%, leukopenia was 12.5%,which were lower than group B(P<0.05);In group A,6-month survival rate was 95.0%,1-year survival rate was 75.0%,18-month survival rate was 50.0%,2-year survival rate was 40.0%,which were higher than group B ( P<0.05).Conclusion Weekly low-dose carboplatin combined with low dose of fluoride urea pyrimidine for elderly patients with advanced colon cancer can significantly improve the treatment efficiency ,increase short-term and long-term survival rate ,with low incidence of adverse reactions ,it is safe and effective.