摘要:
Objective To explore the effect of the treatment of Flurbiprofen Injections on the dose of pain pump and blood coagulation in patients with esophageal cancer.Methods From February 2014 to August 2015,98 cases of esophageal cancer patients who came to our hospital for surgical treatment were divided into treatment group and control group according to the random method,each had 49 cases.The patients of the control group were given pain pump for pain treatment, while the patients of the treatment group were given Flurbiprofen Injections on the base of control group.The Heart rate (HR),systolic blood pressure (SAP),oxygen saturation (SaO2),coagulation,active analgesic frequency,dosage,ICU observing time,the number of cases of respiratory depression,poor expectoration,nausea,abdominal pain,fecal occult blood positive incision oozing analgesic effect and the total satisfaction were detected after the operation and at 36 h after the operation.Results There was no statistically significant difference of HR, SAP,SaO2,PT,APTT,TT,FIB,PLT,the numbers of respiratory depression,nausea,abdominal pain and fecal occult blood positive after operation (P>0.05);HR,SAP and SaO2 of the patients of the treatment group were higher than that of the control group at 36 h after operation,and the numbers of respiratory depression and nausea of the patients of the treatment group were lower than that of the control group at 36 h after operation.The difference was statistically significant (P0.05);术后36 h治疗组患者的HR、SAP及SaO2明显高于对照组,治疗组患者的呼吸抑制及恶心例数明显少于对照组(P<0.05);治疗组患者术后治疗过程中的主动镇痛次数7.85±1.47 次、用药量107.53±12.72 mL、ICU留观时间18.54±2.67 h及咳痰不畅例数(3,6.12%)明显低于对照组9.31±2.89 次、115.37±15.29 mL、20.47±3.53 h、11(22.45%)(P<0.05);治疗组患者镇痛总满意度(47,95.92%)明显高于对照组(41,83.67%)(P<0.05).结论 小剂量应用氟比洛芬酯注射液可明显促进患者术后呼吸系统功能恢复,降低镇痛泵用药量及不良反应发生率,且无明显凝血指标异常等不良反应.