CD23
CD23的相关文献在1989年到2021年内共计81篇,主要集中在基础医学、内科学、儿科学
等领域,其中期刊论文81篇、专利文献8165篇;相关期刊62种,包括中国防痨杂志、现代中西医结合杂志、浙江中西医结合杂志等;
CD23的相关文献由191位作者贡献,包括徐德胜、周云桂、赵海霞等。
CD23
-研究学者
- 徐德胜
- 周云桂
- 赵海霞
- 何世东
- 冯萍
- 刘芳
- 古丽娣
- 唱文娟
- 喻学忠
- 尹兴平
- 徐凯智
- 方怀瑾
- 晋康新
- 朱国际
- 李娜
- 李希清
- 李超乾
- 王斌
- 赵贺堂
- 陈欣洁
- 陈福将
- 陈镇炎
- 韩连书
- 黄绍良
- 一苇
- 丁洁
- 乌维秋
- 仇海荣
- 付志强
- 仲峰
- 仲飞
- 何丽丹
- 何志巍
- 何惹洁
- 傅祖红
- 储晓彬
- 关祥燕
- 冯晓莉
- 凌绍贤
- 刘俊乐
- 刘家秀
- 刘德琮
- 刘春景
- 刘湘玲
- 刘爱华
- 刘秀云
- 刘翠华
- 刘锦
- 吕东思
- 吕凌
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袁婷;
曹铮;
刘秀云;
郑波;
冯晓莉
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摘要:
目的探讨治疗相关标志物PD-L1、PD-L2、CD30、CD23、BCL-2、BCL-6、MUM1和GATA3在原发纵隔大B细胞淋巴瘤(PMBL)诊断和预后评估中的应用价值。方法收集PMBL的34例患者进行回顾性研究,31例非纵隔原发的非特指型弥漫性大B细胞淋巴瘤(DLBCL-NOS)作为对照组,免疫组织化学染色方法检测8种蛋白的表达情况。结果PD-L1、PD-L2和CD30在PMBL组阳性肿瘤细胞百分比的中位数分别为70%(30%,90%)、25%(0,70%)和17.5%(0,60%),显著高于DLBCL-NOS组,差异有统计学意义(P0.05,仍显示出预后差的趋势。结论PMBL中PD-L1、PD-L2和CD30的表达水平较高,有助于精准识别更多可能对免疫或靶向治疗有反应的患者。免疫组织化学标记PD-L1、PD-L2、CD30和CD23有助于PMBL与DLBCL-NOS鉴别诊断。CD30和BCL-6作为PMBL的候选预后指标应该在更大量的样本中进一步研究。
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谭汉旭;
王文革
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摘要:
免疫球蛋白E(IgE)在湿疹等许多自身过敏性疾病的发病机制中扮演重要角色.研究发现,IgE主要通过其在肥大细胞、嗜碱性细胞等细胞上的高亲和力受体FcεRⅠ及低亲和力受体FcεRⅡ(CD23)发挥作用,此外还能通过半乳糖凝集素-3信号通路活化肥大细胞和嗜碱性细胞,最终导致自身免疫性疾病的发生.本文对近期相关文献进行综述,对IgE在湿疹等自身免疫相关性疾病中发挥的作用和可能发病机制进行分析,以期为日后药物研发和临床工作提供指导.
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母发光;
王强;
郑佳;
房俊
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摘要:
Objective To investigate the expressions and variations of TLR2,TLR9,CD19 and CD23 in peripheral blood mononuclear cells of children with infectious mononucleosis ( IM) ,and to explore their role in the pathogenesis of the disease .Methods The clinical data of 30 newly diagnosed IM from April 2015 to February 2016 in our hospital were retrospectively analyzed .The 30 cases were taken as IM acute group .Among them,26 cases whose clinical signs and symptoms disappeared after treatment (4 cases lost follow-up) and course of disease lasted for about 1 month were taken as IM recovery group .Meanwhile,24 children with normal physical examination were taken as control group .The expressions of TLR2 mRNA and TLR9 mRNA in peripheral blood mononuclear cells was detected by SYBR Green I real-time fluorescence quantitative PCR .Flow cytometry was used to detect the positive expression rates of B cells ( CD19+) and immortalized B cells ( CD19+CD23+) in the peripheral blood mononuclear cells .Results The positive expression rate of CD19+and CD19+CD23+in the acute period of children with IM was lower than that in the recovery period ( P<0.05 ) ,and the positive rate of expressions in acute period and recovery period were lower than that in control group ( P<0.05 ) .The expression levels of TLR2 mRNA and TLR9 mRNA in acute period was higher than that in recovery period (P<0.05),and the expression levels in a-cute period and recovery period were higher than that in control group (P <0.05).Conclusion TLR2,TLR9,CD19 and CD23 may play an important role in the pathogenesis of IM in different stages .%目的 了解传染性单核细胞增多症(infectious mononucleosis,IM)患儿不同时期外周血单个核细胞TLR2、TLR9 mRNA和CD19、CD23的表达情况及其变化规律,探讨其在发病中的作用.方法 回顾性分析2015年4月至2016年2月30例我院确诊为IM患儿的临床资料.新诊断IM的30例患儿为IM急性期组,其中26例(失访4例)经治疗临床症状体征消失,病程满1个月为IM恢复期组,同期常规体检健康的24例儿童为对照组.采用SYBRGreen I实时荧光定量PCR方法检测外周血单个核细胞TLR2 mRNA、TLR9 mRNA的表达.采用流式细胞术检测外周血单个核细胞中B细胞CD19+和永生B细胞CD19+CD23+的阳性表达率.结果 IM患儿急性期CD19+及CD19+CD23+表达阳性率低于恢复期(P<0.05),且急性期和恢复期表达阳性率均低于对照组(P<0.05).急性期TLR2 mRNA、TLR9 mRNA表达水平高于恢复期(P<0.05),且急性期和恢复期表达水平均高于对照组(P<0.05).结论 TLR2、TLR9,CD19+CD23+、CD19+在IM不同时期通过对免疫细胞的调节可能参与了IM发病.
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朱妍妍;
林琳;
邱兆丹;
姜红
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摘要:
Objective To observe the changes of peripheral serum IgE and CD23 levels and short clinical effi‐cacy after the treatment of Liuwei Dihuang Pills in children patients with primary nephrotic syndrome .Methods 60 children patients with primary nephrotic syndrome were selected and randomly divided into the control group and the observation group ,30 cases in each group .The control group was given the conventional treatment ,while on this ba‐sis the observation group was given Liuwei Dihuang Pills .The treatment lasted for 6 weeks .The short term clinical efficacy and the changes of peripheral serum IgE and CD23 levels were observed .Results The short term clinical ef‐ficacy after treatment in the observation group was significantly better than that in the control group(P<0 .05);the levels of peripheral serum TC ,TG ,SCr ,BUN and IgE ,CD23 after treatment in the two groups were decreased com‐pared with those before treatment(P<0 .05);the levels of peripheral serum TC ,TG ,SCr ,BUN and IgE ,CD23 after treatment in the observation group were lower than those in the control group(P<0 .05) .Conclusion Giving Liuwei Dihuang Pills on the basis of basic treatment can better improve the short term clinical effect .The comprehensive , careful and normative nursing care during the treatment process is the foundation of the treatment success .%目的:观察经六味地黄丸治疗后的儿童肾病综合征患者外周血清Ig E和CD23的浓度变化及其近期临床疗效。方法选取儿童肾病综合征患者60例,分为对照组和观察组,每组30例,对照组给予常规治疗,观察组在常规治疗的基础上给予六味地黄丸,连续治疗6周,观察两组的近期临床疗效及患者外周血清中Ig E和CD23的浓度变化。结果治疗后观察组近期临床疗效均优于对照组(P<0.05);治疗后两组患者外周血清中总胆固醇(TC)、总三酰甘油(TG)、血清肌酸酐(SCr)、血清尿素氮(BUN)及其IgE、CD23的浓度均较治疗前降低(P<0.05);治疗后观察组患者外周血清中TC、TG、SCr、BUN及其IgE、CD23的浓度均低于对照组(P<0.05)。结论在常规治疗的基础上给予六味地黄丸能很好地改善小儿肾病综合征患者的近期临床疗效。在治疗过程中全面、细致、规范化的护理是治疗成功的基础。
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林荣华;
綦巧雯;
林明祥;
王宪耀;
郭予涛
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摘要:
Objective To explore the correlation between the expressions of IgE and CD23 and primary nephrotic syndrome in children.Methods 52 children with primary nephrotic syndrome and 13 healthy children were recruited into this study.The serum IgE concentrations were detected by immunoradiation assay.The proportion of CD23 positive cells were determined by flow cytometry analysis.Results The IgE concentration and the proportion of CD23+ cells in the children with primary nephrotic syndrome were significantly higher than those of the health counterparts (IgE:[452.5 ± 239.7] vs.[132.6 ± 105.5],P < 0.01; CD23+ cells%:[16.6 ± 7.6] vs.[5.2 ± 3.9],P < 0.05).The serum IgE concentration was obviously higher in the patients with steroid-resistant nephrotic syndrome (SRNS) than in the children with steroid-sensitive nephrotic syndrome (SSNS) before and after the treatment (before the treatment:[462.9 ± 321.2] vs.[382.1 ± 269.0],P < 0.05; after the treatment:[246.7 ± 182.1] vs.[171.7 ± 107.9],P < 0.05).The proportion of CD23+ cells was significantly enhanced in the SRNS children than in the SSNS children before and after the treatment (before the treatment:[19.3 ± 6.4] vs.[15.6 ± 7.7],P < 0.05; after the treatment:[12.2 ± 8.5] vs.[6.1 ± 4.3],P < 0.01).IgE concentration positively correlated with CD23+ proportion in the children with primary nephrotic syndrome (r=0.605,P < 0.05).Conclusions Immune dysfunction was observed in children with primary nephrotic syndrome,as indicated by the abnormal expression of serum IgE concentration and CD23+ cell proportion.Compared to SSNS children,these disorders were more obvious in SRNS children befaore and after treatment.Therefore,a combined testing of serum IgE concentration and CD23+ cell proportion shows great significance in the diagnosis and prognosis evaluation in primary nephrotic syndrome in children.%目的 探讨外周血中IgE和CD23表达水平与儿童原发性肾病综合症的相关性.方法 采用免疫放射法和流式细胞技术检测52例肾病综合症患儿以及13例健康儿童的血清IgE水平和CD23阳性细胞率.结果 肾病综合症患儿的IgE表达水平和CD23阳性细胞率均明显高于对照组的健康儿童,IgE水平:(452.5±239.7) vs.(132.6±105.5),P<0.01; CD23阳性率:(16.6±7.6)vs.(5.2±3.9),P< 0.05,差异具有统计学意义.激素耐药型患儿的IgE的表达水平在治疗前、后均明显高于激素敏感型的患儿,治疗前:(462.9±321.2)vs.(382.1±269.0),P<0.05;治疗后:(246.7±182.1)vs.(171.7±107.9),P<0.05.激素耐药型患儿的CD23阳性细胞率在治疗前、后均明显高于激素敏感型的患儿,治疗前:(19.3±6.4)vs.(15.6土7.7),P<0.05;治疗后:(12.2±8.5)vs.(6.1± 4.3),P< 0.01.并且,患儿的IgE水平与CD23阳性率呈正相关(r=0.605,P<0.05).结论 原发性肾病综合症的患儿血清IgE表达和CD23阳性细胞的免疫功能紊乱,且与激素敏感型患儿相比,激素耐药型患儿的免疫功能紊乱在治疗前、后均更明显.联合检测外周血IgE水平和CD23阳性细胞率在儿童原发性肾病综合症的诊断和预后判断中有重要意义.
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周智源;
孟媛媛
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摘要:
目的 研究外周血CD23、CD30、CD34表达水平与婴幼儿喘息发病的关系和三者之间的关系及其相关性.方法 采用流式细胞分析技术,检测94例观察组(其中包括过敏性喘息组35例、暂时性喘息组29例和非过敏性持续喘息组30例)和42例对照组(急性支气管炎19例、急性支气管肺炎23例)外周血CD23、CD30、CD34的表达水平并作比较.结果 观察组中的过敏性喘息组的CD23、CD30、CD34表达水平分别与暂时性喘息组、非过敏性持续性喘息组和对照组3组之间比较差异均有统计学意义(P0.05).CD23、CD30、CD34三者呈正相关.结论 外周血的CD23、CD30、CD34三者的表达水平在过敏性喘息中均明显升高,与婴幼儿过敏性喘息的发病机制密切相关.
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- 武汉大复生物科技有限公司
- 公开公告日期:2018.02.27
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摘要:
本发明涉及一种检测CD105、CD144、CD34、KDR、Annexin V和CD63的试剂在制备检测血液中的内皮及内皮祖细胞释放的细胞外囊泡的试剂中的应用,从循环系统中分别分离出EC‑MVs、EPC‑MVs、EC‑EXs和EPC‑EXs。该方法突破了以往用单特异性抗体的方法且提取出来的细胞MVs和EXs比现有技术的特异性和敏感性高。此外,本发明利用纳米微粒追踪分析术(NTS)针对细胞MVs和EXs进行特异性抗体micro‑beads方法结合荧光量子点(Q‑dots)方法进行检测。该方法能快速,准确,客观分析复杂样本例如血液中EC‑MVs,EPC‑MVs,EC‑EXs和EPC‑EXs的水平,有传统分析方法例如流式所不具备的优势。因此,本发明为进一步研究MVs和EXs作为疾病的生物标记物提供了特异和敏感的方法。
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