摘要:
目的 通过建立前庭诱发肌源性电位(VEMPs)的检测技术,研究前庭脑干通路的完整性,探讨VEMPs在中枢神经系统疾病中的诊断及临床应用价值.方法 收集2016年4月至2017年7月健康志愿者72名,男女各36名,按年龄分为6组,所有受检者均接受短声刺激,分别在上斜肌、咬肌及胸锁乳突肌记录,得到稳定波形:(1)对侧眼部电位(o-VEMP)N1、P1;(2)双侧咬肌电位(m-VEMP)P11;(3)同侧颈区电位(c-VEMP)P13、N23.测量潜伏期、峰峰值波幅、刺激前后波幅比率、比率的log值.结果 N1、P11、P13的潜伏期均值分别为10.9~12.0 ms、11.3~13.6 ms、13.2~14.6 ms,其中o-VEMP、m-VEMP和c-VEMP的健康受试者检出率分别为97.2%、98.5%和95.4%.随着年龄增长,可以看到各波的潜伏期有所延长,差异有统计学意义(P0.05).结论 VEMPs测定技术无创,稳定可靠,可以从三个节段客观评价前庭脑干通路的完整性,在中枢神经系统疾病中,特别是神经变性病中有广泛的应用前景.%Objective To study the integrity of vestibular brain stem pathway and explore the diagnostic and clinical value of vestibular-evoked myogenic potentials ( VEMPs ) in central nervous system diseases through the establishment of detection method of VEMPs .Method Seventy-two normal volunteers ( included between April 2016 and July 2017 ) were divided into 6 groups according to different ages .All subjects were tested with short acoustic stimulation .The superior oblique , masseter and sternocleidomastoid muscles were recorded respectively , and the stable waveform was obtained:(1)the Opposite ocular potential ( o-VEMP) N1 and P1;( 2 ) the bilateral masseter potential ( m-VEMP ) P11;( 3 ) the same side neck potential ( c-VEMP) P13 and N23.The three detection methods were used to measure the latency period , the amplitude of the peak value , the ratio of the amplitude before and after the stimulus , and the logarithm value of the ratio.Results The mean values of latency period of N 1, P11 and P13 were 10.9-12.0 ms, 11.3-13.6 ms, 13.2 -14.6 ms, among which the occurrence rates of o-vemp, m-vemp and c-vemp were respectively 97.2%, 98.5% and 95.4%.With the increase of age , the latency period of each wave was observed to be prolonged , with significant difference ( P 0.05).Conclusions VEMPs are noninvasive measurement technology , stable and reliable , and can objectively evaluate the integrity of the vestibular brainstem pathway from three segment.This technology has broad application prospects in the central nervous system diseases , especially in neurodegenerative disease .