摘要:
从中国特有属药用植物裸蒴中分离得到4个新的联苯四氢呋喃型阻转异构体木脂素,命名为裸蒴木脂素X1, X2, Y1, Y2(1~4),其结构通过HR-ESIMS,1D和2D NMR等光谱技术确定.对4个新化合物进行了5种癌细胞的筛选,结果显示化合物1对HCT116, HCT15, A549, MCF-7和HepG2都有中等强度的抑制作用,其IC50值分别为18.4,11.2,26.5,9.1,23.5μmol•L-1.%Four new biphenyl lignans with a tetrahydrofuran moiety, named gymnothelignans X1, X2, Y1, and Y2 (1~4), were isolated from the methanol extract of the whole plants of Gymnotheca chinensis Decne. The chemical structures were established by means of spectroscopic analysis including 1D and 2D NMR spectroscopy and HR-ESIMS. Compound 1 exhib-ited moderate cytotoxicity against the HCT116, HCT15, A549, MCF-7 and HepG2 cancer cell lines with IC50 values of 18.4, 11.2, 26.5, 9.1 and 23.5μmol•L-1, respectively.