摘要：
Objective To understand the immune status of healthy population in Deyang city,so as to provide scientific basis for the prevention and control of vaccines preventable diseases,e.g.measles,rubella,mumps,pertussis and diphtheria.Methods In 2012 and 2016,stratified random sampling was used to collect subjects from 7 age groups (＜1,1-2,3-4,5-6,7-14,15-19 and ≥20 years old) in Deyang City.A total of 428 healthy people were tested by ELISA to determine the levels of serum IgG against measles,rubella,mumps,pertussis and diphtheria.The geometric mean concentrations (GMC) and the positive rates of protective antibodies were also calculated.Results Of the 428 study subjects,the levels of IgG against measles,rubella,mumps,pertussis and diphtheria were 78.74％ (337/428),64.95％ (278/428),65.65％ (281/428),27.34％ (117/428) and 81.31％ (348/428),respectively.The positive rate of measles protective antibody was 35.51％ (152/428).The GMCs of the five diseases were 881.54 mIU/mL,97.62 IU/mL,456.70 U/mL,34.70 IU/mL and 2.15 IU/mL,respectively.The positive rate of measles IgG was the lowest in the ＜ 1 year-old group (49.15％,29/59).The positive rate of rubella IgG was the lowest in ＜ 1 year-old group (40.68％,24/59).The group with the lowest mumps IgG was ＜ 1 year-old group (33.90％,20/59).The positive rate of pertussis IgG was the lowest in 1-2 years old group (13.33％,8/60).The positive rate of diphtheria IgG was the lowest in the ≥20-year-old group (66.67％,46/69).GMCs of antibodies against measles,rubella,and mumps were the lowest in the ＜ 1 year-old group (627.70 mIU/ mL,57.58 IU/mL,166.87 U/mL,respectively).The GMC of pertussis antibody at 3-4 year-old group was the lowest (22.18 IU/mL) while GMC of diphtheria antibody in ≥ 20-year-old group was the lowest (0.11 IU/mL).Conclusions The levels of antibody against measles,rubella,mumps,pertussis and diphtheria in healthy population in Deyang City was relatively low.Timely vaccination of measles rubella vaccine should be strengthened for 8-months-old infants.The vaccination rate of mumps-containing vaccines and pertussis-containing vaccines for children at appropriate age should be increased,and the vaccination should be standardized to improve the immunization level of healthy people.%目的 了解四川省德阳市健康人群麻疹、风疹、腮腺炎、百日咳和白喉等疾病抗体水平.方法 于2012年和2016年分别在四川省德阳市分层随机抽取＜1岁、1～2岁、3～4岁、5～6岁、7～14岁、15～19岁、≥20岁等7个年龄组健康人群共428名作为监测对象,均采集4～5 mL静脉血并分离血清标本2 mL.采用酶联免疫吸附试验(ELISA)检测血清标本中麻疹、风疹、腮腺炎、百日咳、白喉IgG抗体水平,计算几何平均浓度(GMC)及抗体阳性率.结果 428名研究对象中,麻疹、风疹、腮腺炎、百日咳和白喉IgG抗体阳性率分别为78.74％(337/428)、64.95％(278/428)、65.65％(281/428)、27.34％(117/428)、81.31％(348/428),麻疹保护性抗体阳性率为35.51％(152/428);5种疾病GMC分别为881.54 mIU/mL、97.62 IU/mL、456.70 U/mL、34.70 IU/mL、2.15IU/mL.麻疹IgG抗体阳性率＜1岁组最低(49.15％,29/59);风疹IgG抗体阳性率＜1岁组最低(40.68％,24/59);腮腺炎IgG抗体＜1岁组最低(33.90％,20/59);百日咳IgG抗体阳性率1～2岁组最低(13.33％,8/60);白喉IgG抗体阳性率≥20岁组最低(66.67％,46/69).麻疹、风疹、腮腺炎抗体GMC均＜1岁组最低(627.70 mIU/mL、57.58 IU/mL、166.87 U/mL);百日咳抗体GMC在3～4岁组最低(22.18 IU/mL);白喉抗体GMC≥20岁组最低(0.11 IU/mL).结论 德阳市健康人群麻疹、风疹、腮腺炎、百日咳和白喉抗体水平相对较低,重点加强8月龄麻疹风疹二联疫苗接种率和接种及时性;加强适龄儿童含腮腺炎成分疫苗、百白破成分疫苗的接种率.
