摘要：
Objective To investigate the clinical effect of Calcipotriol Ointment combined with Transfer Factor Injection in treatment of lichen planus. Methods Patients (90 cases) with lichen planus in Huangshi Central Hospital of Edong Medical Group from June 2014 to August 2016 were randomly divided into the control group (40 cases) and the treatment group (50 cases). Patients in the control group were topical administered with Calcipotriol Ointment, 1 g/time, twice daily. And patients in the control group were po administered with Quinine sulfate Tablets, 0.3 g/time, twice daily, after 1 week, changed to once daily. Patients in the treatment group were topical administered with Calcipotriol Ointment, 1 g/time, twice daily. And patients in the treatment group were intramuscular injection administered with Transfer Factor Injection, 3 mg/time, once weekly. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and lymphocyte subsets, cytokine levels, and PASI scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.50％ and 96.00％, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of CD4+ and CD4+/CD8+ in two groups were significantly increased, but the levels of CD8+ in tow groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of IL-18, IL-6, and hs-CRP in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the PASI scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Calcipotriol Ointment combined with Transfer Factor Injection has clinical curative effect in treatment of lichen planus, can improve clinical symptoms and immune function, and regulate cytokine level, with good safety, which has a certain clinical application value.%目的 探讨卡泊三醇软膏联合转移因子注射液治疗扁平苔癣的临床疗效.方法 选取2014年6月—2016年8月在鄂东医疗集团黄石市中心医院治疗的扁平苔癣患者90例为研究对象,所有患者按照随机分组原则随机分为对照组(40例)和治疗组(50例).对照组外用卡泊三醇软膏,1 g/次,2次/d;同时口服硫酸奎宁片,0.3 g/次,2次/d,1周后改为1次/d.治疗组外用卡泊三醇软膏,1 g/次,2次/d;同时肌肉注射转移因子注射液,3 mg/次,1次/周.两组均连续治疗3个月.观察两组的临床疗效,比较两组的淋巴细胞亚群、细胞因子水平和银屑病面积与严重性指数(PASI)评分.结果 治疗后,对照组和治疗组的总有效率分别为77.50％、96.00％,两组比较差异有统计学意义(P<0.05).治疗后,两组CD4+、CD4+/CD8+水平显著升高,CD8+水平显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05).治疗后,两组白细胞介素-18(IL-18)、白细胞介素-6(IL-6)、高敏C反应蛋白(hs-CRP)水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05).治疗后,两组PASI评分均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05).结论 卡泊三醇软膏联合转移因子注射液治疗扁平苔癣具有较好的临床疗效,可改善临床症状和免疫功能,调节细胞因子水平,安全性较好,具有一定的临床推广应用价值.
