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应变率成像

应变率成像的相关文献在2001年到2019年内共计219篇,主要集中在内科学、临床医学、基础医学 等领域,其中期刊论文213篇、会议论文4篇、专利文献114591篇;相关期刊86种,包括中国保健营养、医学影像学杂志、中国超声医学杂志等; 相关会议4种,包括中国超声医学工程学会第十一届全国超声医学学术大会、全国医学影像学术研讨会、中华医学会第十次全国超声医学学术会议等;应变率成像的相关文献由533位作者贡献,包括郭瑞强、陈金玲、周青等。

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论文:213 占比:0.19%

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论文:4 占比:0.00%

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论文:114591 占比:99.81%

总计:114808篇

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应变率成像

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  • 郭瑞强
  • 陈金玲
  • 周青
  • 张海滨
  • 张军
  • 郝力丹
  • 初洪钢
  • 郭盛兰
  • 周晓东
  • 田家玮
  • 期刊论文
  • 会议论文
  • 专利文献

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    • 林桂粧; 邱鹏远; 何燕红
    • 摘要: 目的 探讨采用应变率成像(SRI)评价冠心病经皮冠状动脉介入(PCI)术治疗前后左室局部心肌功能的变化.方法 选择2017年2月至2018年2月佛山市南海区第四人民医院心内科诊治的62例行PCI治疗的冠心病患者为研究组,并选择50例门诊体检健康者为对照组,所有受试者均进行超声心动图检查,SRI评价左室局部舒张和收缩功能,研究组冠心病患者于术前、术后1个月进行SRI检查,观察PCI前后左室局部心肌功能的变化.结果 研究组患者术前的后间隔中间段、后间隔心尖段、侧壁心尖段、前壁基底段、前壁中间段、前壁心尖段、前间隔基底段、前间隔中间段、前间隔心尖段收缩期应变率(SRs)、舒张早期应变率(SRe)、舒张晚期应变率(SRa)均低于对照组,差异均有统计学意义(P<0.05);治疗后,研究组患者的后间隔中间段、后间隔心尖段、侧壁心尖段、前壁基底段、前壁中间段、前壁心尖段、前间隔基底段、前间隔中间段、前间隔心尖段SRs、SRe、SRa均明显升高,差异均有统计学意义(P<0.05).结论 PCI术可改善冠心病患者心功能,SRI可定量评价PCI术治疗前后左室局部心肌功能变化.
    • 刘俊峰; 苏菁; 李朝喜; 李小娟
    • 摘要: Objective: To explore the advantage of ultrasonic image technique of strain rate imaging(SRI) in the evaluation for the left ventricular myocardial regional systolic and diastolic function, induced by chemotherapeutic drug, of patients with breast cancer. Methods: 90 female patients with breast cancer who were confirmed by pathological diagnosis were selected in the research. After the operation of breast cancer, all of them were implemented chemotherapy that included auxiliary 5-fluorouracil, pharmorubicin and cyclophosphamide(FEC). The self-control study was adopted to observe these patients in the 6 chemotherapy cycle from the first week to the sixth week. And the detections of myocardial enzymes, routine echocardiography and SRI were implemented at the first day pre chemotherapy and the fifth day post each chemotherapy period. The change of each indicator was observed. Results:With the increasing of accumulation of chemotherapeutic drug, the results of SRI showed that SRe, SRa and SRs of the middle part of sixth cycle were significantly lower than that of pre chemotherapy (t=2.401, t=2.246, t=2.334, P<0.05). The SRe of sixth cycle post chemotherapy was significantly lower than that of various part pre chemotherapy (t=9.67, t=5.46, t=7.02, t=9.11, t=7.38, t=8.24, P<0.05). And the SRa of sixth cycle post chemotherapy was significantly lower than that of various part pre chemotherapy (t=7.21, t=6.21, t=9.48, t=8.72, t=5.47, t=7.39, P<0.05). The SRs value of sixth cycle was significant decreased (t=8.18, t=9.27, t=5.37, t=6.25, t=5.54, t=8.93, P<0.05). On the other hand, the results of routine echocardiography showed that the transmitral diastolic early peak inflow velocity/transmitral diastolic late peak inflow velocity (E/A) of sixth cycle was significantly lower than that of pre chemotherapy (t=6.67, P<0.05). The levels of aspartate aminotransferase (AST), creatine phosphokinase isoenzyme(CPK-MB), lactate dehydrogenase(LDH), creatine phosphokinase (CPK), and alpha-hydroxybutyrate dehydrogenase (HBDH) of the sixth cycle were significantly higher than that of pre chemotherapy (t=9.66, t=7.56, t=5.57, t=6.62, t=8.89, P<0.05). Conclusions: The SRI technique can accurately reflect the influence of chemotherapeutic drugs for left ventricular function of patients with breast cancer at early period.%目的:探讨应变率成像(SRI)超声影像技术在评价化疗药物致乳腺癌患者左室心肌局部收缩及舒张功能影响中的优势.方法:选择90例经病理确诊的女性乳腺癌患者,经乳腺癌术后均采用辅助5-氟尿嘧啶+表阿霉素+环磷酰胺(FEC)方案化疗.采用自身对照研究对乳腺癌患者1~6周的6个化疗周期进行观察,分别于化疗前1 d及每周期化疗后第5 d行心肌酶学、常规超声心动图及应变率成像检测,并观察各指标变化情况.结果:随化疗药物累积量增加,应变率成像结果显示,第6个周期中部舒张压早起峰值应变率(SRe)、房缩期峰值应变率(SRa)、收缩期峰值应变率(SRs)与化疗前比较明显降低,差异有统计学意义(t=2.401,t=2.246,t=2.334;P<0.05).化疗后第6个周期与化疗前各部位相比SRe显著性降低,差异有统计学意义(t=9.67,t=5.46,t=7.02,t=9.11,t=7.38,t=8.24;P<0.05);化疗后第6个周期与化疗前各部位相比SRa显著性降低,差异有统计学意义(t=7.21,t=6.21,t=9.48,t=8.72,t=5.47,t=7.39;P<0.05);第6个周期时SRs值明显降低(t=8.18,t=9.27,t=5.37,t=6.25,t=5.54,t=8.93;P<0.05).常规超声心动图结果显示,化疗后与化疗前相比,第6周期时,患者的二尖瓣口舒张早期血流速度E峰与舒张晚期血流速度A峰比值(E/A)降低,差异有统计学意义(t=6.67;P<0.05);第6周期时谷草转氨酶(AST)、肌酸磷酸激酶同功酶(CPK-MB)、乳酸脱氢酶(LDH)、肌酸磷酸激酶(CPK)以及α-羟丁酸脱氢酶(α-HBDH)水平均显著升高(t=9.66,t=7.56,t=5.57,t=6.62,t=8.89;P<0.05).结论:应变率成像技术能够早期较精确的反映化疗药物对乳腺癌患者左心功能的影响.
    • 刘俊峰; 刘伟亮; 陆海永; 陈云璇; 温德惠; 王义成; 郜新春
    • 摘要: 目的 探讨应变率显像技术对蒽环类化疗药物致乳腺癌患者右心室功能影响的评价作用.方法 选取2015年10月~2016年10月在河北北方学院附属第一医院经病理确诊、采用CAF化疗方案的80例女性乳腺癌患者.所有研究对象采取自身对照的方式,分别于化疗前ld及每次化疗周期的第5天获取常规超声心动图参数及应变率数据.结果 在第6个化疗周期后,受试者的三尖瓣瓣环收缩期位移低于化疗前,右心室心肌功能指数高于化疗前(P<0.05).应变/应变率显像发现,与治疗前相比,乳腺癌患者蒽环类药物化疗第6周期后整体径向应变、整体长轴应变率及整体圆周应变显著下降(P<0.05).结论 应变率成像能够早期反映蒽环类药物致乳腺癌患者右心室功能的改变.
    • 吴崴
    • 摘要: 目的采用超声组织追踪(TTI)联合应变率显像技术(SRI)对冠心病患者左心室收缩功能的检测价值。方法选取天津市南开区中医医院心内科2016年3月-2018年3月收入的冠心病患者30例为研究组,另选取同期在该院进行体检的健康人群30例为对照组,两组均进行超声心脏功能检查,分析两组TTI联合SRI对左心室收缩功能的评价效果。结果研究组不同位置检测出各节段水平均值明显低于对照组(P0.05)。结论 TTI联合SRI对冠心病左心室收缩功能的评价准确,值得在临床推广。
    • 刘俊峰; 苏菁; 李朝喜; 李小娟
    • 摘要: 目的:探讨应变率显像技术在评价表阿霉素致乳腺癌患者左室心肌局部收缩及舒张功能影响中的优势.方法:选择经医院病理确诊的90例女性乳腺癌患者,均采用5-氟尿嘧啶-表阿霉素/表柔吡星-环磷酰胺(FEC)方案化疗.采用自身对照研究对乳腺癌患者6个化疗周期进行观察,分别于化疗前1 d及每周期化疗后第5 d行心肌酶学、常规超声心动图及应变率成像检测.结果:随表阿霉素累积量增加,应变率成像结果显示,与化疗前相比基底部舒张早期峰值应变率(SRe)、舒张晚期峰值应变率(SRa)在第5周期时发生明显降低,差异有统计学意义(SRe:F=1.923,P<0.05;SRa:F=2.245,P<0.05);第6周期收缩期峰值应变率(SRs)明显降低,差异有统计学意义(基底部:t=2.334,P<0.05;中部:t=2.401,P<0.05).常规超声心动图结果显示,第6周期时,受试患者的左室舒张早期充盈峰/舒张晚期充盈峰(E/A)较化疗前减低,差异有统计学意义(t=2.953,P<0.05);且谷草转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸磷酸激酶(CK)、肌酸磷酸激酶同功酶(CK-MB)以及α-羟丁酸脱氢酶(HBDH)在第6周期时出现升高,与化疗前相比差异有统计学意义(t=1.991,t=1.231,t=2.301,t=1.844,t=1.599;P<0.05).结论:应变率成像能够早期较精确的反映表阿霉素致乳腺癌患者左心功能的影响.%Objective: To explore the advantages of strain rate imaging in evaluating the effect of epirubicin for left ventricular myocardial regional systolic and diastolic function of patients with breast carcinoma. Methods: 90 patients with breast carcinoma received FEC chemotherapy (5- Fu, epirubicin and cyclophosphamide) were enrolled in the self- control study. There were 6 chemotherapy periods of them were observed, and the detection of myocardial enzyme, routine echocardiography and strain rate imaging for patients were implemented before one day of chemotherapy and after fifth day of chemotherapy, respectively. Results: The results of strain rate imaging revealed, with the increasing of cumulant of epirubicin, the SRe and SRa of basilar part post-chemotherapy were obviously decreased than that pre-chemotherapy at fifth period, and the differences between pre and post chemotherapy were significant (SRe: F=1.923, P<0.05; SRa: F=2.245, P<0.05). At sixth period, the SRs was obviously decreased, and the difference between them was significant ( basilar part: t=2.334, P<0.05, middle part: t=2.401, P<0.05). The results of routine echocardiography revealed that the E/A of patients post chemotherapy was significant lower than that of patients pre chemotherapy (t=2.953, P<0.05) in 6th period. On the other hand, the AST, LDH, CK, CK-MB and HBDH of post chemotherapy were significant higher than that of pre-chemotherapy (t=1.9911, t=1.231, t=2.301, t=1.844, t=1.599, P<0.05). Conclusions: The strain rate imaging can relatively precisely reflect the effect of epirubicin for left ventricular function of patient with breast carcinoma in early stage.
    • 祝云; 章鸣; 欧阳敏稚; 周丹; 李玲
    • 摘要: Objective To investigate the roles of myeloid differentiation factor 88 (MyD88) and TIR domain-containing adaptor inducing interferon-β (TRIF) in sepsis-induced myocardial dysfunction, and to analyze whether strain rate (SR) can be early sensitive evaluation for septic heart failure.Methods Sixty-four healthy male C57BL/6 mice were divided into four groups by random number table (n = 16 in each group): sham group, cecum ligation and puncture (CLP)-induced sepsis model group, anti-MyD88 group and anti-TRIF group. The anti-MyD88 group and anti-TRIF group were injected with 5μL/g of anti-MyD88 antibody or anti-TRIF antibody through the tail veins 2 hours before CLP. Eight animals in each group were used to observe the survival of 24 hours, and the other 8 myocardial tissues were harvested for examination. The cardiac function was evaluated by echocardiography before and 6 hours and 12 hours after operation. The mRNA expressions of MyD88, TRIF and inflammatory factors in myocardium were measured by polymerase chain reaction (PCR) at 24 hours after operation, and the degree of neutrophils infiltration was detected by myeloperoxidase (MPO) activity.Results The number of 24-hour survive in anti-MyD88 group and anti-TRIF group were higher than that in CLP group (number: 4, 3 vs. 2,P = 0.044,P = 0.047). Compared with sham group, the cardiac function was significantly decreased, the mRNA expressions of myocardial tissues MyD88, TRIF, interleukin (IL-1, IL-6) and tumor necrosis factor-α (TNF-α) were significantly increased, and the infiltration of neutrophils were obvious in CLP group. Compared with CLP group, the left ventricular short axis fractional shortening rate (FS) and SR were significantly increased after 12 hours in anti-MyD88 group and anti-TRIF group [FS: (49.52±1.78)%, (49.89±1.49)%vs. (41.11±1.63)%, SR (s-1): 17.63±2.16, 17.85±1.64 vs. 12.55±1.84]; the mRNA expressions of MyD88, TRIF and inflammatory factors were significantly decreased [MyD88 mRNA (A value): 0.463±0.046, 0.505±0.048 vs. 0.638±0.102, TRIF mRNA (A value): 0.413±0.031, 0.410±0.021 vs. 0.625±0.057, IL-1 mRNA (A value):0.569±0.101, 0.570±0.091 vs. 0.946±0.171, IL-6 mRNA (A value): 0.551±0.143, 0.431±0.157 vs. 0.850±0.194, TNF-α mRNA (A value): 0.471±0.082, 0.444±0.093 vs. 0.707±0.094]; and the infiltration of neutrophils were significantly decreased [MPO (U/L): 62.34±2.60, 60.87±2.40 vs. 73.83±4.90], with statistically significant differences (allP 0.05).Conclusions Blocking MyD88 and TRIF expression play significant and similar roles in protecting cardiac deterioration from sepsis by attenuating cytokine release, reducing neutrophil infiltration. SR can sensitively assess septic cardiac dysfunction.%目的 探讨髓样分化因子88(MyD88)和β-干扰素TIR结构域衔接蛋白(TRIF)在脓毒症所致心肌功能障碍中的作用;分析应变率(SR)能否早期敏感评价脓毒症性心功能不全.方法 按随机数字表法将64只健康雄性C57BL/6小鼠分为假手术(Sham)组、盲肠结扎穿孔术(CLP)致脓毒症模型组、抗MyD88组和抗TRIF组,每组16只.抗MyD88组和抗TRIF组分别于术前2 h经尾静脉注射抗MyD88抗体5μL/g或抗TRIF抗体5μL/g.每组8只动物用于观察24 h存活情况;另8只取心肌组织备检.于术前及术后6 h和12 h用超声心动图评价心功能;术后24 h用聚合酶链反应(PCR)测定心肌组织MyD88、TRIF和炎性因子的mRNA表达,通过检测髓过氧化物酶(MPO)活性了解心肌中性粒细胞浸润程度.结果 抗MyD88组和抗TRIF组小鼠24 h存活动物数多于CLP组(只:4、3比2,P值分别为0.044和0.047).与Sham组比较,CLP组心功能明显下降,心肌组织MyD88、TRIF、白细胞介素(IL-1、IL-6)、肿瘤坏死因子-α(TNF-α)的mRNA表达明显升高,中性粒细胞浸润明显.与CLP组比较,抗MyD88组和抗TRIF组术后12 h左室短轴缩短率(FS)、SR明显升高〔FS:(49.52±1.78)%、(49.89±1.49)%比(41.11±1.63)%,SR(s-1):17.63±2.16、17.85±1.64比12.55±1.84〕,MyD88、TRIF、炎性因子的mRNA表达明显降低〔MyD88 mRNA(A值):0.463±0.046、0.505±0.048比0.638±0.102,TRIF mRNA(A值):0.413±0.031、0.410±0.021比0.625±0.057,IL-1 mRNA(A值):0.569±0.101、0.570±0.091比0.946±0.171,IL-6 mRNA(A值):0.551±0.143、0.431±0.157比0.850±0.194,TNF-αmRNA(A值):0.471±0.082、0.444±0.093比0.707±0.094〕,中性粒细胞浸润明显减少〔MPO(U/L):62.34±2.60、60.87±2.40比73.83±4.90〕,差异均有统计学意义(均P0.05).结论 阻断MyD88和TRIF表达可以减少炎性因子释放和中性粒细胞浸润,从而延缓脓毒症所致心功能恶化,且二者作用近似.心肌SR是评价脓毒症性心功能不全的早期敏感指标.
    • 周丹; 章鸣; 欧阳敏稚; 唐逵
    • 摘要: 目的 探讨应变率分析是否能够敏感、准确地评价脓毒症所致心功能不全,观察脓毒症所致心功能不全心肌组织Toll样受体4 mRNA(TLR4 mRNA)的表达.方法 盲肠结扎穿孔法(CLP)建立小鼠脓毒症模型.小鼠分为假手术组(Sham,n=20)和脓毒症组(CLP,n=32).Sham组与CLP组分别观察小鼠的存活情况至术后7d,于术后24 h行离体心脏灌流术.Sham组与CLP组在术前及术后各个时间点行超声心动图,术后采集心脏组织标本.qRT-PCR检测心肌组织TLR4 mRNA的表达.结果 术后CLP组小鼠96 h死亡率约80%,而Sham组无死亡(P<0.05).超声心动图显示,CLP组较Sham组12、24h心功能有轻度下降,左室舒张末期内径略有扩张(P>0.05),而左室后壁应变率明显下降(P<0.05).离体心脏灌流法显示,CLP组较Sham组心功能明显降低(P<0.05).术后CLP组心肌TLR4 mRNA的表达与Sham组比较12h即开始升高,24h仍明显升高(P<0.05).结论 脓毒症心肌组织内TLR4 mRNA的高表达可能与脓毒症心功能障碍有关,心肌应变率分析是评价脓毒症所致心功能不全的早期敏感指标.
    • 赵白桦; 刘明辉; 刘成晓; 蒲大容; 戴茜
    • 摘要: 目的:应用应变率成像技术(SRI)动态观察和评价吗啡预处理对兔心肌缺血再灌注损伤时左室长轴功能的影响.方法:建立新西兰大白兔心肌缺血再灌注模型,随机分为假手术组(SH组)、吗啡预处理组(MF组)和生理盐水预处理组(NS组).于手术前1天及手术术后28天内不同时间点测量超声心动图常规数据及左室各壁收缩期峰值速度与应变率参数.结果:术后1天,MF组与NS组左室整体与局部心肌收缩功能较术前和SH组明显减低(P<o.05),并随缺血再灌注时间的延长呈减低趋势(P<0.05),且NS组减低更明显(P<0.05).结论:SRI技术能够客观、准确地评价缺血再灌注损伤心肌的局部收缩功能的变化,而吗啡预处理对兔心肌缺血再灌注损伤存在明显的弱化作用.
    • 彭继红
    • 摘要: Objective To observe myocardial velocity and strain rate characteristics in patients with acute myocardial ischemia(AMI) of emergency,and to evaluate the clinical value of quantitative tissue velocity imaging(QTVI)and strain rate imaging(SRI)in quanti-tative assessment of left ventricular(LV)region infarction myocardial function.Methods Thirty two patients with AMI of coronary heart disease(CHD),30 control subjects were enrol ed in the study.Longitudinal peak velocity,strain rate of LV anterior wal (AW) and anterior interventricular septum(AS)during systole,early diastole and atrium contraction(VS,VE,VA),(SRS,SRE,SRA) were measured at different levels(basal,middle and apical).QTVI and SRI data were compared with coronary angiography results. Results VS:different levels of LV infarction wal significantly decreased in CHD group.VE:al levels of LV infarction wal ,except for apex levels of AS,were significantly lower than those in control group.VA:different levels of AW and apex level of AS in CHD group were significantly lower than those in control group.SRS and SRE:al levels of LV infarction wal in CHD group were significantly low-er than those in control group.SRA:different levels of AW and base level of AS in CHD group were significantly lower than those in control group (P<0.05,P<0.01 respectively).Conclusion QTVI and SRI are sensitive and feasible in evaluating functions of congestive heart failure of myocardial ischemia of emergency.%目的:探讨定量组织速度成像(QTVI)及应变率成像(SRI)在急诊心肌缺血中的临床应用价值。方法应用QTVI及SRI对32例急诊心肌缺血病人和30例正常人节段纵向收缩期(S)、舒张早期(E)及收缩期(A)的峰值速度(VS、VE、VA)、峰值应变率(SRS、SRE、SRA)进行测定。结果 VS:心肌缺血组室壁的不同水平均较正常对照组显著性减低;VE:除前间隔的心尖水平外,室壁较正常对照组显著性减低;VA:前壁的不同水平及前间隔的心尖水平心肌缺血组较对照组显著性减低;SRS、SRE:心肌缺血组不同水平左室室壁较对照组显著性减低;SRA:前壁的不同水平及前间隔的基底水平心肌缺血组较对照组显著性减低(P<0.05或P<0.01)。结论 QTVI及 SRI技术是临床简便、无创,是准确评价急诊心肌缺血的有效方法。
    • 李新刚; 陶红; 胡荣; 李荣娟; 王文川
    • 摘要: 目的 探讨心外膜脂肪与2型糖尿病患者早期心功能改变相关性.方法 对2013年10月到2014年9月北京安贞医院内分泌科所有研究对象相关指标进行统计分析,收集研究对象一般临床资料、测定生化指标、评价心功能,测量心外膜脂肪体积.结果 (1)2型糖尿病组腰围、体重指数、空腹血糖、糖化血红蛋白、三酰甘油、心外膜脂肪体积明显高于对照组(P<0.05),2型糖尿病组左室壁收缩期应变率(SRs)、舒张早期应变率(SRe)减低(P<0.05).(2)多元线性回归分析显示,心外膜脂肪体积与左室壁后间隔基底段收缩期应变率(SRs)、下壁中段舒张早期应变率(SRe)密切相关.结论 心外膜脂肪体积与2型糖尿病早期心功能改变密切相关,提示心外膜脂肪可能是2型糖尿病心功能改变新的危险因素及潜在的治疗靶点.
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