摘要：
目的 观察血清对氧磷酯酶-1(PON-1)、salusin-α和网膜素-1(Omentin-1)在老年急性脑梗死患者检测中的临床意义.方法 急性脑梗死患者75例,为急性脑梗死组,和同期行健康体检者30例.观察组血清PON-1,Salusin-α和Omentin-1水平的变化,急性脑梗死患者机体PON-1,Salusin-α和Omentin-1水平与颈动脉斑块性质,梗死面积和神经功能缺损的关系及其各指标之间的相关性分析.结果 急性脑梗死组的PON-1、Salusin-α和Omentin-1水平明显低于健康对照组(P<0.01).急性脑梗死患者血清PON-1,Salusin-α和Omentin-1水平随着颈内动脉斑块不稳定程度,脑梗死面积和神经损害程度的增加而降低(P<0.01).急性脑梗死患者血清PON-1水平与salusin-α和Omentin-1水平呈正相关(r值分别为0.572、0.487,P<0.05),salusin-α水平与Omentin-1水平呈正相关(r=0.752,P<0.05).结论 PON-1,salusin-α和Omentin-1参与了老年急性脑梗死发生发展过程,是急性脑梗死重要的保护因子,早期监测有助于对病情的判断和预后具有重要临床价值.%Objective To investigate the clinical significance of serum paraoxonase-1 (PON-1),Salusin-α and Omentin-1 in elderly patients with acute cerebral infarction (ACI).Methods Seventy-five elderly patients with ACI who were treated in our hospital from January 2014 to June 2016 were enrolled as ACI group, at the same time, the other 30 healthy subjects were served as control group.The serum levels of PON-1,Salusin-α and Omentin-1 were detected by enzyme-linked immunosorbent assay (ELISA).The correlation betweeen the levels of PON-1,Salusin-α , Omentin-1 and carotid plaque character,infarction area, neurologic impairment was analyzed,moreover, the correlation among these indexes was also analyzed.Results The serum levels of PON-1,Salusin-α and Omentin-1 in ACI group were significantly lower than those in control group (P<0.01).The levels of PON-1,Salusin-α and Omentin-1 in ACI group were decreased with the increase of unstable degree of carotid artery plaque,cerebral infarction area and neurologic impairment severity (P<0.01).The levels of serum PON-1 in ACI group were positively correlated to those of Salusin-α (r=0.572,P<0.05) and Omentin-1 (r=0.487,P<0.05), moreover, the levels of Salusin-α were also positively correlated to those of Omentin-1 (r=0.752,P<0.05).Conclusion The PON-1,Salusin-α and Omentin-1 are involved in the pathogenesis and development of acute cerebral infarction in elderly patients,and these indexes are important protective factors for patients with ACI,thus,the early monitoring of these indexes is helpful to evaluate pathogenetic condition and prognosis of patients.
