Target

摘要： Extracellular vesicles are composed of fragments of exfoliated plasma membrane,organelles or nuclei and are released after cell activation,apoptosis or destruction.Platelet-derived extracellular vesicles are the most abundant type of extracellular vesicle in the blood of patients with traumatic brain injury.Accumulated laboratory and clinical evidence shows that platelet-derived extracellular vesicles play an important role in coagulopathy and inflammation after traumatic brain injury.This review discusses the recent progress of research on platelet-derived extracellular vesicles in coagulopathy and inflammation and the potential of platelet-derived extracellular vesicles as therapeutic targets for traumatic brain injury.

摘要： Melanoma is a relentless type of skin cancer which involves myriad signaling pathways which regulate many cellular processes.This makes melanoma difficult to treat,especially when identified late.At present,therapeutics include chemotherapy,surgical resection,biochemotherapy,immunotherapy,photodynamic and targeted approaches.These interventions are usually administered as either a single-drug or in combination,based on tumor location,stage,and patients'overall health condition.However,treatment efficacy generally decreases as patients develop treatment resistance.Genetic profiling of melanocytes and the discovery of novel molecular factors involved in the pathogenesis of melanoma have helped to identify new therapeutic targets.In this literature review,we examine several newly approved therapies,and briefly describe several therapies being assessed for melanoma.The goal is to provide a comprehensive overview of recent developments and to consider future directions in the field of melanoma.

摘要： Background:By using the method of network pharmacology to explore the action mechanism of Fuzhengjieyudecoction in the treatment of tumor-associated depression.Methods:The BATMAN-TCM platform was used to obtain the active ingredients of Fuzhengjieyudecoction andrelated targets,and the GeneCards,OMIM and TTD databases were used to screen the tumor-related depression targets,and the Venny platform was used to make a Venn diagram to screen the intersecting targets.The STRING platform was used to perform PPI analysis on the intersecting targets and Cytoscape 3.7.2 software was used to perform topological parameter analysis to find key core targets.We used Cytoscape 3.7.2 to construct compound-target network diagrams of the intersecting targets to screen out the important active ingredients.We used the DAVID platform to perform the enrichment analysis of gene ontology biological functions and genome encyclopedia pathways to predict the biological processes and pathways of action.Results:A total of 414 active ingredients of Fuzhengjieyudecoction were screened,corresponding to 866 gene targets,and 1416 tumor-associated depression-related targets were screened,with a total of 150 intersecting targets between the two.The results of gene ontologyand genome encyclopediaenrichment showed that the main biological processes involved were negative regulation of transcription from RNA polymerase II promoterRNA,response to oxidative stress,negative regulation of growth of symbiont in the host,cellular response to lipopolysaccharide,positive regulation of interleukin-8 biosynthesis process,positive regulation of transcription from RNA polymerase II promoterRNA,oxidation-reduction process,response to the drug,regulation of cell proliferation,multicellular organism growth,and so on.The main pathways involved were Pathways in cancer,HIF-1 signaling pathway,Estrogen signaling pathway,Proteoglycans in cancer,Prolactin signaling pathway,TNF signaling pathway and so on.Conclusion:Fuzhengjieyudecoction exerts its therapeutic effects on tumor-associated depression by acting on targets such as AKT1,MAPK1,INS,PI3KCA,PI3KR1,TNF,etc and regulating multiple signaling pathways such as Pathways in cancer,HIF-1 signaling pathway,Estrogen signaling pathway,Proteoglycans in cancer,Prolactin signaling pathway,TNF signaling pathway,etc.

摘要： 目的旨在通过广义线性模型的差异表达筛选及功能富集探究复方金果胃康散在胃癌的治疗作用,为后续开展中药治疗癌症提供基础研究方向和临床的理论基础。方法从TARGET数据库下载胃癌患者临床信息和测序RNA数据。通过中国知网等文献数据库及TCMSP对复方金果胃康散所有中药的有效成分及蛋白进行收集整理,运用Excel、计算机R语言基本算法整理复方金果胃康散的蛋白质,将TARGET导出的胃癌患者样本数据整理后进行聚类分析,再通过计算机R语言构建Limma和功能富集从而分析治疗作用。结果复方金果胃康散7种药物包含有效成分1814种,蛋白358种。TARGET中共获得443个胃癌患者的样本,表达谱共获得27226个基因,剔除了部分数据不全的样本,最后在407个样本中进行数据分析,将复方金果胃康散与胃癌患者取交集共获得352个基因。根据单因素Cox分析产生的352个预后基因,采用一致聚类方法将胃癌患者分为C1和C2两个亚组。175例患者被聚类为聚类1,232例患者被聚类为聚类2。Limma分析结果为差异倍数为1.2的前提下,发现了98个上调基因,70个下调基因。KEGG结果显示复方金果胃康散基因主要在癌症通路富集,并且能富集多种癌症通路,PPI分析确定了8个亚模型。GSEA显示DNA损伤反应对miRNA的调控、巨型BII淋巴细胞上升、DNA损伤反应、肝癌、P75-NTR通路和ATM-信号通路等相关。结论复方金果胃康散作为沈舒文教授和宋健副教授在胃癌治疗的临床常用方,从分子角度数据结果显示复方金果胃康散对胃癌有很好的治疗作用,同时也阐明了在分子层面复方金果胃康散治疗作用的机制途径。

摘要： Eucommiae Folium(EF),a traditional Chinese medicine,has been used to treat secondary hypertension,including renal hypertension and salt-sensitive hypertension,as well as hypertension caused by thoracic aortic endothelial dysfunction,a high-fat diet,and oxidized low-density lipoprotein.The antihypertensive components of EF are divided into four categories:flavonoids,iridoids,lignans,and phenylpropanoids,such as chlorogenic acid,geniposide acid and pinoresinol diglucoside.EF regulates the occurrence and development of hypertension by regulating biological processes,such as inhibiting inflammation,regulating the nitric oxide synthase pathway,reducing oxidative stress levels,regulating endothelial vasoactive factors,and lowering blood pressure.However,its molecular antihypertensive mechanisms are still unclear and require further investigation.In this review,by consulting the relevant literature on the antihypertensive effects of EF and using network pharmacology,we summarized the active ingredients and pharmacological mechanisms of EF in the treatment of hypertension to clarify how EF is associated with secondary hypertension,the related components,and underlying mechanisms.The results of the network pharmacology analysis indicated that EF treats hypertension through a multicomponent,multi-target and multi-pathway mechanism.In particular,we discussed the role of EF targets in the treatment of hypertension,including epithelial sodium channel,heat shock protein70,rhoassociated protein kinase 1,catalase,and superoxide dismutase.The relevant signal transduction pathways,the ras homolog family member A(RhoA)/Rho-associated protein kinase(ROCK)and nicotinamide adenine dinucleotide phosphate(NADPH)oxidase/eNOS/NO/Ca^(2+)pathways,are also discussed.

摘要： BACKGROUND Immune cells play a role in the regulation of tumor cell behavior, and accumulating evidence supports their significance in predicting outcomes and therapeutic efficacy in colorectal cancers(CRC). Human six-transmembrane epithelial antigen of the prostate(STEAP) proteins have been recognized and utilized as promising targets for cell-and antibody-based immunotherapy. One STEAP family member, STEAP4, is expected to be an attractive biomarker for the immunotherapy of prostate and breast cancer. However, the immunotherapeutic role of STEAP4 for colorectal carcinomas has not been demonstrated.AIM To explore the expression pattern of STEAPs in CRC and their relationship with immune infiltration, and investigate the potential utilization of STEAPs as novel prognostic indicators in colorectal carcinomas.METHODS The expression level of STEAPs in CRC was evaluated using various openresource databases and online tools to explore the expression characteristics and prognostic significance of STEAPs, as well as their correlation with immunerelated biomarkers, such as immune infiltration. Immunohistochemical(IHC) experiments were subsequently performed to verify the database conclusions.RESULTS The levels of STEAPs in CRC were inconsistent. The expression of STEAPs 1-3 in CRC was not significantly different from that in normal tissues. However,STEAP4 mRNA levels were significantly lower in CRC than in normal tissue and were positively correlated with immune-related biomarkers, such as immune cell infiltration, immune stimulation, major histocompatibility complex levels, and chemokines. Interestingly, the expression of STEAP4 in microsatellite instability-high CRC subtype was higher than that in microsatellite stability subtype. IHC staining was performed on colon cancer tissue samples and showed that high expression of STEAP4 in adjacent tissues positively correlated with immune-related biomarkers, including MLH1, MLH6, and PMS2, but negatively correlated with programmed death ligand 1, to varying degrees.CONCLUSION Our results provide an analysis of the expression of STEAP family members in CRC. Among different STEAP family members, STEAP4 plays a different role in CRC compared to STEAPs 1-3. In CRC, STEAP4 expression is not only lower than that in normal tissues, but it is also positively correlated with immune infiltration and immune-related biomarkers. These findings suggest that STEAP4 may be a potential biomarker for predicting CRC immune infiltration status.

摘要： China is gradually establishing a multidisciplinary diagnosis and treatment system of traditional Chinese medicine(TCM)and western medicine.TCM-drug combination is prone to adverse reactions.Clinical feature is the appearance of adverse reactions,and target is the internal mechanism.The establishment of feature and target correlation model will contribute to the development of this field.This paper introduces the four steps of feature-target correlation method that risk identification,feature extraction,sign target correlation and experimental research.Xiyanping-Ribavirin combination is as an example to illustrate this method.It is expected that the method will be popularized and applied to protect clinical safety.

摘要： 传统预测基因表达的线性模型无法解决基因表达谱数据高维度、少样本和非线性的现实问题.对此提出一种基于直连输入输出深度神经网络(DCIO-DNN)和迁移学习的基因表达回归预测模型(DCIO-DNN_GM).提出一种可以建模landmark和target基因的线性和非线性映射关系的新型网络结构;引入迁移学习策略和正则化技术在小数据集上训练了模型.实验结果表明,该模型各项指标都更高.

摘要： Chinese medicine.However,little is known about the potential mechanism.Elucidating the effective components and mechanism based on network pharmacology was our purpose.Methods:Traditional Chinese Medicine Systems Pharmacology was screened to collect the possible active ingredients and their CAS and SMILES was searched in Pubchem,and the related potential targets were further predicted in Swiss Target Prediction database.Coronary heart disease molecular members were gained from GeenCards database,and the predicted targets of Cinnamomi Ramulus for coronary heart disease’s treatment were selected by Wayne diagram.As for mechanism analysis,String was used to construct the protein-protein interactions,and DAVID was used to conduct the GO and KEGG analysis.Results:Through GO and KEGG analysis,we found that cAMP signaling pathway,estrogen signaling pathway,calcium signaling pathway was related with coronary heart disease.Using network-based systems biology,we predicted that 10 active ingredients in Cinnamomi Ramulus have the treating effects with 78 potential targets.PIK3CG,MAPK8,BCL-2,BAX,PRKACA,CASP3,CALM1,CALM2,CALM3,NOS2,NOS3 were mainly involved in the treating effects of Cinnamomi Ramulus.Conclusion:Cinnamomi Ramulus may treat coronary heart disease through cAMP signaling pathway,estrogen signaling pathway,calcium signaling pathway.PIK3CG,MAPK8,BCL-2,BAX,PRKACA,CASP3,CALM1,CALM2,CALM3,NOS2,NOS3 were supposed to be considerable targets for treating coronary heart disease.

摘要： The distribution and sources of EMPs produced at Shenguang-Ⅱ(SG-Ⅱ)series laser facilities are systematically investigated.The results indicate that the EMP amplitudes in the SG-Ⅱps PW laser are very strong,one order higher than those from the SG-Ⅱlaser facility.EMPs outside the target chamber decrease exponentially with the distance from the measuring points to the target chamber center at the two laser facilities.Moreover,EMPs can be remarkably reduced when the picosecond laser together with the nanosecond laser is incident to targets compared to the SG-Ⅱps PW laser alone.The resulting conclusions are expected to offer experimental supports for further effective EMPs shielding design and achievement in high-power laser facilities.

摘要： 本文研究了8keV,27keV单能中子参考辐射场核反应靶的设计，分析了目前国际上keV能区两种主要核反应7Li(p，n)7Be，45Sc(p,n)45Ti的优缺点，采用45Sc(p,11)45Ti反应作为8keV,27keV单能中子参考辐射场中子产生核反应。为满足质子束流强度最大50μA，设计特殊的靶头冷却系统。利用Target程序模拟计算了中子参考辐射场中子能谱，分析了铜，钽，铁三种材料作为靶头材料对中子参考辐射场中子能谱的影响。

摘要： 本文研究了8keV,27keV单能中子参考辐射场核反应靶的设计，分析了目前国际上keV能区两种主要核反应7Li(p，n)7Be，45Sc(p,n)45Ti的优缺点，采用45Sc(p,11)45Ti反应作为8keV,27keV单能中子参考辐射场中子产生核反应。为满足质子束流强度最大50μA，设计特殊的靶头冷却系统。利用Target程序模拟计算了中子参考辐射场中子能谱，分析了铜，钽，铁三种材料作为靶头材料对中子参考辐射场中子能谱的影响。

摘要： 本文研究了8keV,27keV单能中子参考辐射场核反应靶的设计，分析了目前国际上keV能区两种主要核反应7Li(p，n)7Be，45Sc(p,n)45Ti的优缺点，采用45Sc(p,11)45Ti反应作为8keV,27keV单能中子参考辐射场中子产生核反应。为满足质子束流强度最大50μA，设计特殊的靶头冷却系统。利用Target程序模拟计算了中子参考辐射场中子能谱，分析了铜，钽，铁三种材料作为靶头材料对中子参考辐射场中子能谱的影响。

摘要： 本文研究了8keV,27keV单能中子参考辐射场核反应靶的设计，分析了目前国际上keV能区两种主要核反应7Li(p，n)7Be，45Sc(p,n)45Ti的优缺点，采用45Sc(p,11)45Ti反应作为8keV,27keV单能中子参考辐射场中子产生核反应。为满足质子束流强度最大50μA，设计特殊的靶头冷却系统。利用Target程序模拟计算了中子参考辐射场中子能谱，分析了铜，钽，铁三种材料作为靶头材料对中子参考辐射场中子能谱的影响。

摘要： 本发明提供了一种分布式存储系统中ISCSI Target负载均衡方法和装置，分布式存储系统包括管理节点和数据节点，每个数据节点中均部署多个ISCSI Target，该方法应用于管理节点，包括：监控所有数据节点中的ISCSI Target的使用状态；根据每个数据节点中各ISCSI Target的使用状态确定该数据节点的负载量；根据所有数据节点中的ISCSI Target的使用状态确定所有数据节点的平均负载量；针对每个数据节点，根据该数据节点的负载量和所述平均负载量对该数据节点执行负载均衡操作。本发明能够解决分布式存储系统的负载均衡问题。

摘要： 本发明提供一种基于Target‑Aspect‑Opinion联合抽取的短文本评论情感分析方法。本发明首先对短文本数据集进行预处理，筛选有效数据，然后对数据集进行预标注工作，然后构建基于Target‑Aspect‑Opinion联合抽取的情感分析模型。本发明提出的联合抽取模型，解决了现有模型中单独抽取Target或Aspect等带来的识别不全面问题，以及通过构建TargetTaggers和Aspect‑OpinionTaggers，有效解决了目标词重叠问题。

摘要： 本发明提供一种基于TOE网卡的Target端协议硬件解析方法，发起端经TOE网卡向目标端发送ISCSI PDU，网卡的FPGA对TCP payload数据流进行PDU帧界定，找出BHS字段和AHS字段与数据段；AHS字段和数据段写入TOE网卡DDR，BHS字段写入Host DDR；网卡的驱动层对获取的BHS字段，判断BHS字段长度是否大于预设值，若判断为是，则驱动层将PDU剩余信息传至Host DDR；若判断为否，则应用层将Host DDR中PDU全部信息传至CPU。本发明对ISCSI PDU的BHS字段和AHS字段与数据段进行分流处理，与传统方式相比，明显降低CPU负载并提升整体传输效率。

摘要： 本发明提供一种基于Target‑Aspect‑Opinion联合抽取的短文本评论情感分析方法。本发明首先对短文本数据集进行预处理，筛选有效数据，然后对数据集进行预标注工作，然后构建基于Target‑Aspect‑Opinion联合抽取的情感分析模型。本发明提出的联合抽取模型，解决了现有模型中单独抽取Target或Aspect等带来的识别不全面问题，以及通过构建TargetTaggers和Aspect‑OpinionTaggers，有效解决了目标词重叠问题。

摘要： 本发明涉及计算机技术领域并提供了Target端的选择方法、分布式集群系统及计算机可读介质，该Target端的选择方法用以对分布式集群系统中节点自客户端发起访问请求予以响应的节点中的运行Target进程的Target端予以选择；选择方法包括监控节点的使用状态并保存，接收自客户端的Initiator进程下发的配置策略，调用节点的使用状态并根据节点选择策略确定匹配与自客户端发起访问请求相适应的Target端。本发明能够在分布式集群系统中各个节点与客户端之间断开时，从分布式集群系统中自动选取可用的Target端，避免了在选取可用的Target端后对整个分布式集群系统各个节点间资源配置不均衡的问题。

摘要： 本发明公开一种tgt的iSCSI‑target配置全局化的管理方法，包括S100，集群中创建共享的target配置信息的存储池，在存储池中创建target配置文件；S200，集群节点配置新的target时，检查所述target配置文件和集群节点内存，删除检索到的相匹配的失效target，将新的target配置信息写入所述target配置文件；S300，集群节点访问target时，检查所述target配置文件和内存，根据target配置文件中的target信息，创建连接；S400，集群节点删除target时，检查所述target配置文件和内存，删除检索的相匹配的target。本发明将tgt的iSCSI‑target配置信息持久化至分布式集群，不需要消耗额外的带宽和操作进行节点之间的配置信息的同步；涉及到的target操作均对配置文件和集群内存检查，排除无效的target相关信息的干扰，保证集群正常对客户端提供服务。

摘要： 本申请公开了一种分布式存储集群的target管理方法，应用于分布式存储集群的主节点中，包括：接收target创建请求；通过解析target创建请求得到配置信息，并基于配置信息生成用于创建target的消息；将生成的消息置入消息队列中，以使得分布式存储集群中的每一个从节点在监听到消息之后进行target的创建。应用本申请的方案，可以在分布式存储集群中进行target的快速创建，且不会过度占用主节点的资源。本申请还公开了一种分布式存储集群的target管理相关组件，具有相应技术效果。

摘要： 本发明提供了一种iscsi target多路径分组的方法、装置、设备及可读介质，该方法包括：响应于iscsi target的管理工具启动，获取后端存储集群的节点信息；将获取到的节点信息填入节点分配表中并初始化节点分配表；响应于接收到创建逻辑卷映射的指令，基于用户设置的路径数选择节点分配表中路径数最少的存储节点进行分配；更新节点分配表。通过使用本发明的方案，能够使所有target的路径均匀的分散在后端存储节点上，减少不同target间路径的影响，充分发挥存储节点的读写性能。

摘要： 本发明提供了一种iscsi target tgt架构优化方法及系统。该方法包括：在加载iscsi驱动程序时，在iscsi target上已申请的内存空间中建立内存池；基于已经建立的内存池，完成对iscsi target上内存的物理IO。本发明提供的iscsi target tgt架构优化方法及系统能够使得IO读写稳定性提升、性能提升。

摘要： 本发明涉及一种实现嵌入式VxWorks系统更改IP地址后建立target server的方法，属于嵌入式软件开发领域。本发明在VxWorks集成开发环境中，创建一个静态库工程；在静态库工程源程序中，定义一个函数；在函数中声明“传入启动参数”结构变量，并对变量进行赋值；调用WDB初始化函数和WDB系统悬挂函数；编译静态库工程生成静态库文件；将静态库添加到应用软件中，在执行连接target server之前，调用静态库的入口函数。本发明提高了VxWorks嵌入式操作系统连接target server，通过网络进行调试的适用性，方便了应用程序的开发调试，增强了硬件环境对软件开发调试的支撑性，本发明可在应用软件更改网卡IP地址的情况下，仍可实现target server的连接，该方法可行性强，稳定可靠。