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Binswanger病

Binswanger病的相关文献在1989年到2019年内共计140篇,主要集中在神经病学与精神病学、内科学、临床医学 等领域,其中期刊论文138篇、会议论文2篇、专利文献53961篇;相关期刊92种,包括现代诊断与治疗、中国民康医学、临床医学等; 相关会议2种,包括第九次全国中西医结合影像学术交流大会、第四届全国老年流行病学学术会议等;Binswanger病的相关文献由297位作者贡献,包括陈春富、郭洪志、贾海燕等。

Binswanger病—发文量

期刊论文>

论文:138 占比:0.26%

会议论文>

论文:2 占比:0.00%

专利文献>

论文:53961 占比:99.74%

总计:54101篇

Binswanger病—发文趋势图

Binswanger病

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  • 陈春富
  • 郭洪志
  • 贾海燕
  • 李庆华
  • 贺燕
  • 唐明耀
  • 唐静怡
  • 孟红旗
  • 尚文鹏
  • 屈传强
  • 期刊论文
  • 会议论文
  • 专利文献

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    • 任鑫; 孙远征
    • 摘要: 目的 探讨原络通经针法在Binswanger病所致轻度认知功能障碍患者中治疗效果与安全性.方法 选取2017年7月—2018年12月于本院就诊的Binswanger病所致轻度认知功能障碍患者60例作为研究对象,采用随机数字表法分为治疗组(盐酸多奈哌齐片+原络通经针法针刺)和对照组(盐酸多奈哌齐片)两组,每组各30例.对比观察两组患者治疗前后简易精神状态检查量表(MMSE)评分、长谷川痴呆量表(HDS)的认知功能受损程度的临床评价、听觉诱发电位P300变化情况以及两组患者不良反应发生率.结果 治疗前,两组患者MMSE评分和HDS评分比较无统计学意义(P>0.05);治疗后,两组患者MMSE评分和HDS评分较治疗前均明显增加,且治疗组患者增加程度更显著(P0.05);治疗后,两组患者P300潜伏期缩短、波幅增高,且治疗组患者变化程度更显著(P0.05).结论 原络通经针法针刺治疗能够提高Binswanger病所致轻度认知功能障碍的认知能力,改善脑组织电生理功能,安全性较好,具有一定的临床应用价值.
    • 张群; 麻琳; 江文静; 单培彦
    • 摘要: Objective To investigate the influence of the different degree of internal carotid stenosis on the white matter lesion and cognition of Binswanger disease.Methods A total of 108 elderly patients with Binswanger disease from Department of Geriatric Neurology of Qilu Hospital were recruited during December 2013 and June 2014.At the end of follow-up,6 cases showed acute eerebrovaseular disease,39 (< 10 %) had no internal carotid stenosis,31 (10 %-49 %) had mild internal carotid stenosis,32 (50%-70%)had moderate internal carotid stenosis through B ultrasound examination and MRI and MRA examination on internal carotid artery and brain.The B ultrasound examination of internal carotid artery included intima-media thickness (IMT),plaque index and the peak systolic velocity (PSV).Cognitive function of Binswagner disease was assessed by Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MOCA).The white matter lesion was assessed by reformed visual Scheltens scale.The relationship among IMT,plaque index,PSV,white matter lesion,and cognitive function was investigated.The variation of cognition was observed after 1 year.Results There were statistically significant differences in IMT,PSV,plaque index,reformed Scheltens scale scores between groups of non,mild,moderate internal carotid stenosis (all P <0.05).The IMT was thicker in moderate internal carotid stenosis group than in mild internal carotid stenosis group (P<0.05).The differences in PSV,plaque index,and reformed Scheltens scale scores between mild and moderate internal carotid stenosis groups were not significant (P>0.05).There were positive correlation between PSV and reformed Scheltens scale scores (r=0.630,P =0.020).There were negative correlation between PSV and MMSE scores (r=-0.970,P=0.040).The scores of MMSE and MOCA both were declined after 1 year in three groups (0.61 ± 0.60,0.68 ± 0.81),(0.70±0.60,0.93±0.69),(1.06±0.68,1.13±0.76).The declination of MMSE and MOCA of BD patients was higher in moderate internal carotid stenosis group than in non internal carotid stenosis group (P<0.05).The differences in the declination of MMSE and MOCA between moderate and mild internal carotid stenosis groups were not significant (P> 0.05).Conclusions Internal carotid stenosis is one of risk factors for the cognitive impairment of BD,the abnormal IMT and PSV are both correlated with white matter lesion and cognitive impairment in BD.Early standardized therapy can postpone the rate of cognitive impairment in BD.%目的 探讨不同程度颈内动脉狭窄对Binswanger病的脑白质病变及认知功能的影响.方法 收集2012年12月至2014年6月于齐鲁医院老年神经内科住院且合并颈内动脉粥样硬化Binswanger病(BD)患者108例,随访过程中6例发生急性脑血管病结束随访,剩余人数根据颈内动脉狭窄程度分为无狭窄组(<10%)39例、轻度狭窄组(10%~49%)31例、中度狭窄组(50%~70%)32例.所有患者均行颈动脉超声及颅脑磁共振成像(MRI)、磁共振血管造影(MRA)检查,探测颈内动脉内膜中层厚度(IMT)、斑块指数、收缩期峰值流速(PSV)及狭窄率;行简易智能精神状态检查量表(MMSE)、蒙特利尔认知评估量表(MOCA)评估患者认知功能改变;改良Scheltens量表评估脑白质病变;评估颈内动脉IMT、PSV及斑块指数与脑白质病变及认知功能的关系,随访1年后,观察患者认知功能变化.结果 轻、中度狭窄组IMT、斑块指数、PSV、改良Scheltens量表得分较无狭窄组差异有统计学意义(均P<0.05);中度狭窄组IMT(1.11±0.17)mm,明显高于轻度狭窄组(1.04±0.10)mm(P<0.05),轻、中度狭窄组间斑块指数、PSV、改良Scheltens量表差异无统计学意义(均P>0.05).改良Scheltens量表得分与狭窄处PSV呈正相关(r=0.630、P=0.020),MMSE得分与狭窄处PSV呈负相关(r=-0.970、P=0.040).随诊1年后,无狭窄组、轻度狭窄组、中度狭窄组BD患者MMSE得分较前分别下降(0.61±1.05)分、(0.70±0.60)分、(1.06±0.68)分,MOCA较前分别下降(0.68±0.81)分、(0.93±0.69)分、(1.13±0.76)分,且中度狭窄组MMSE、MOCA得分下降幅度最大,较无狭窄组差异明显,有统计学意义(均P<0.05),较轻度狭窄组差异无统计学意义(均P>0.05).结论 颈内动脉狭窄为BD患者认知功能损伤的危险因素,其中IMT和PSV与BD患者脑白质及认知功能损伤关系密切.
    • 周瑜; 梁静静; 曾艳平; 罗瑛; 黄兴汉; 卢祖能
    • 摘要: Objective To investigate the effects of dl-3n-butylphthalide on cerebrovascular reactivity and cog-nitive function in patients with Binswanger disease( BD). Methods Sixty patients with BD were randomly assigned into treatment group and control group,30 patients in each group. Both groups were given vinpocetine intravenously once a day for two weeks,and treatment group were also given dl-3n-butylphthalide orally,200 mg once,3 times a day. Transcranial color Doppler ultrasound and breathing-holding test were used to detect the mean velocity of double side middle cerebral artery( MCA)and cerebrovascular reactivity. The therapeutic effects were measured with Event-related potential P300,MMSE and HDS. Results The mean velocity and cerebrovascular reactivity of MCA were improved after dl-3n-butylphthalide treatment. The latency of P300 was reduced and the amplitude of P300 was increased in treat-ment group compared with patients before treatment,and the scores of MMSE and HDS were also improved obviously after treatment. The total effective rates of dl-3n-butylphthalide and control group were 73. 3% and 46. 7% respectively (P﹤0. 05). Conclusion Dl-3n-butylphthalide has therapeutic potential in the treatment of Binswanger disease.%目的:探讨丁苯酞对 Binswanger 病患者脑血管反应性及认知功能的影响。方法将60例Binswanger病患者随机分为治疗组和对照组,每组30例,对照组给予长春西汀注射液静滴,治疗组在此基础上给予丁苯酞软胶囊口服,200 mg/次,3次/d;疗程为2周。治疗前后应用经颅多普勒超声屏气试验评价脑血管反应性,同时进行P300数据采样和MMSE、HDS量表评分以及疗效评价。结果丁苯酞治疗后大脑中动脉的平均流速和血管反应性显著改善,治疗组治疗前、后P300波潜伏期及P300波幅比较,差异均有统计学意义( P﹤0.05);MMSE和HDS量表评分显著改善,治疗组有效率为73.3%,明显高于对照组的46.7%,差异有统计学意义( P﹤0.05)。结论丁苯酞治疗Binswanger病安全有效。
    • 蔡志友; 涂汉军
    • 摘要: 众所周知,脑血管疾病已成为全球社会各界人士关注的疾病之一。除大血管疾病外,近年来国际会议热点议题引出了脑小血管病(cerebral small vessel diseases,CSVD),逐渐认识到CSVD对健康的危害性。CSVD约占缺血性卒中的20%~30%,流行病学显示CSVD是与年龄密切相关的疾病,所以,CSVD逐渐导致许多老年人出现认知、精神和肢体功能障碍,并且增加了卒中的发生。
    • 巴庆华
    • 摘要: 目的:探讨Binswanger病(BD)患者血脂的变化情况。方法分别测定73例BD患者和64例健康志愿者甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(ApoA1)及载脂蛋白B(ApoB)的浓度,用T检验分析血脂水平与BD的关系。结果 BD组TG、TC水平均显著高于对照组,而ApoA1水平显著低于对照组(P<0.01)。2组间LDL-C、HDL-C、ApoB水平差异无统计学意义。BD组患者TG、TC及 ApoB水平异常检出率均高于对照组。对照组 HDL-C、ApoA1异常检出率高于BD组。结论 BD患者血浆 TG、TC、ApoA1水平差异显著,可能为BD发病的危险因素。
    • 曾宪杰; 孙光裕; 曾培灿; 林玉芳
    • 摘要: Objective To observe impact of monosialotetrahexosylganglioside (GM1) sodium on cognition and daily living ability of patients with Binswanger.Methods 56 cases of Binswanger were randomly divided into treatment group and control group with 28 cases in each group,and patients were given traditional treatment.Treatment group was added with GM1 sodium infusion,while control group was treated with citicoline infusion.After 14 days of treatment,changes in cognition and daily living ability of two groups were evaluated by Mini-mental State Examination (MMSE) scale and Activities of Daily Living (ADL) scale.Results For treatment group,the total effective rate of MMSE scale improvement was 75%,and that of ADL scale improvement was 67.86%.But for control group,the total effective rate of MMSE scale improvement was 35.71%,and that of ADL scale improvement was 32.14%.Therefore,the treatment group was significantly superior to the control group,with statistically significant differences (P < 0.05).Conclusion GM1 sodium treatment can better improve cognition and daily living ability of patients with Binswanger.%目的 观察单唾液酸四己糖神经节苷脂钠对Binswanger病患者认知力及日常生活能力的影响.方法 将56例Binswanger病患者随机分为治疗组和对照组各28例,两组患者均予常规治疗,治疗组患者在此基础上给予单唾液酸四己糖神经节苷脂钠静滴,对照组患者给予胞二磷胆碱静滴,14天后采用MMSE量表和ADL量表评价两组患者的认知力及日常生活能力变化情况.结果 治疗组患者MMSE量表改善总有效率为75%、ADL量表改善总有效率为67.86%,对照组患者MMSE量表改善总有效率为35.71%、ADL量表改善总有效率为32.14%.结论 单唾液酸四己糖神经节苷脂钠治疗Binswanger病能够较好改善患者认知力及日常生活能力.
    • 凌问非; 史小娥
    • 摘要: 目的:对Binswanger病的颅脑CT诊断结果进行观察分析。方法:收治Binswanger病患者65例,作为研究对象,患者均行颅脑CT平扫,对影像结果进行分析。结果:65例患者CT表现为弥漫性低密度区或脑白质内斑片状,边缘为月晕状;为对称性分布,其中Ⅰ型33例,Ⅱ型24例,Ⅲ型8例;合并脑萎缩62例,腔隙性脑梗死58例。结论:CT在Binswanger病的诊断中具有显著价值,对其鉴别诊断有重要作用。%Objective:To observe and analyze the diagnosis result of brain CT of Binswanger disease.Methods:To admit patients with Binswanger disease,as the object of study,patients underwent brain CT scan,to analyze the imaging results.Results:65 cases of patients with CT showed diffuse low density area or white matter patchy,edge for the halo shape;symmetrical distribution, including 33 cases of type Ⅰ,24 cases of type Ⅱ,8 cases of type Ⅲ;62 cases with cerebral atrophy,58 cases with lacunar cerebral infarction.Conclusion:CT has significant value in diagnosis of Binswanger disease,have an important role in the diagnosis and differential diagnosis of Binswanger disease.
    • 钟文; 董建新
    • 摘要: 目的 探讨梅州地区客家人Binswanger病的临床特点.方法 对确诊的76例Binswanger病的临床资料进行回顾性分析.结果 Binswanger病危险因素包括高血压病、糖尿病、高脂血症及吸烟,临床表现不一,CT主要表现为脑白质低密度灶、脑梗死等.结论 积极治疗高血压、糖尿病、高脂血症,对预防本病有积极的意义.
    • 巴庆华; 冯树涛; 韩卓娅; 崔月梅
    • 摘要: 目的 探讨血浆同型半胱氨酸(Hcy)水平与Binswanger病(BD)的关系.方法 应用荧光极化免疫法测定50例BD患者和53例健康体检者(健康对照组)的血浆Hcy水平,采用相关统计学方法进行分析.结果 BD组患者血浆Hcy水平(19.84±7.26)μmol/L,显著高于健康对照组的(15.00±5.76) μmol/L(P<0.01).结论 高Hcy血症可能参与了BD的发病过程.
    • 杨映珊; 伍爱民; 陆正齐; 张炳俊; 门雪娇; 胡学强
    • 摘要: 目的 探讨高同型半胱氨酸(Hcy)、高纤维蛋白原(Fib)等对Binswanger病(BD)脑白质疏松(LA)严重程度的影响.方法 对自2005年1月1日至2011年5月9日在中山大学附属第三医院住院且确诊为BD的患者进行血清Hcy、Fib、低密度脂蛋白(LDL)、载脂蛋白A(Apoa)、载脂蛋白B(Apob)、高密度脂蛋白(HDL)检测,并将BD患者按LA头颅MRI表现严重程度分为轻、中、重3型,单因素分析及有序Logistic回归法分析Fib、Hcy等因素与LA严重程度的关系.结果 单因素分析结果显示:LA不同严重程度组间性别、年龄、高血压病、卒中史、高脂血症比较差异有统计学意义(P<0.05).LA严重程度与Hcy、Fib存在正向的等级相关关系(P<0.05).有序Logistic回归分析结果显示:女性LA程度比男性更严重;年龄越大,有卒中史和Fib测定值越大,LA程度更严重(P<0.05).结论 Fib水平是BD恶化的一个重要因素,降低Fib水平可能对延缓BD病情进展有效.%Objective To investigate the correlation between severity of leukoaraiosis (LA) and plasma levels of homocysteine and fibrinogen in patients with Binswanger disease (BD).Methods All patients with BD,admitted to our hospital from January 2005 to May 2011,were selected consistently with the diagnostic criteria of Bennett.The levels of plasma homocysteine (Hcy),fibrinogen (Hcy),low-density lipoprotein (LDL),apolipoprotein A (Apoa),apolipoprotein B (Apob),and high-density lipoprotein (HDL) were measured.According to the Kinkel's classification of BD,the severity of LA was graded as mild,moderate,or severe by its appearance under MRI.The relation between levels of plasma Hcy and Fib and severity of LA in BD patients were analyzed.Results Single factor analysis indicated that the dispositions of gender,age,hypertensive disease,stroke and hyperlipoidemia in BD patients with different severities of LA were significantly different (P<0.05).The severity degree of LA was positively correlated with the levels of Hcy and Fib (P<0.05).Ordered logistic regression analysis showed that female was severer than male in the severity of the LA in BD patients; age,stroke and level of plasma Fib were positively related to the severity of LA in BD patients (P<0.05).Conclusion The high plasma level of Fib is an important factor for BD deterioration; reducing the level of plasma Fib may delay the aggravation of BD.
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