Skin

摘要： BACKGROUND The association of Sjögren's syndrome(SS)and lymphoma is similar.Mucosaassociated lymphoid tissue(MALT)or extranodal marginal zone B-cell lymphoma was the most common lymphomatous histology in SS patients.MALT in SS patients is frequently located in the parotid gland,while MALT lymphoma of the skin with SS is an exceedingly rare entity that needs to be recognized.CASE SUMMARY A 60-year-old woman presented with a 3-year history of progressive dry mouth associated with a 1-year history of enlarging cutaneous nodules.Physical examination revealed two hard subcutaneous nodules on her right lower leg.The results of Schirmer’s test were positive,despite the absence of dry eyes.Labial salivary gland biopsy revealed lymphocytic infiltration and chronic inflammation with a focus score of 2.The patient was diagnosed with SS.She underwent resection of one cutaneous nodule,and histopathological analysis identified the nodule as MALT lymphoma.Her dry mouth symptoms improved,and the nodules decreased after 6 mo of treatment with hydroxychloroquine sulfate and chemotherapy(thalidomide,cyclophosphamide,and dexamethasone).CONCLUSION Lymphoma is a severe complication of SS,shown by the reported unique case of cutaneous MALT lymphoma with SS.

摘要： Second Skin市政服务厅坐落于葡萄牙菲盖拉达福什港,紧挨蒙台哥河。项目的前身是一座有两百年历史的老宅,经danielmsantos eng+arq事务所翻修改造后重获了新的生命。大胆的设计为老宅插入一处引人注目的球体,同时也唤起了人们对这座优雅的港口城市繁华过往的美好回忆。市政服务厅所在的老建筑曾是一座庄园,现在作为一处办公场所,承担着当地市政的多项服务功能。

摘要： Developing products that foster a healthy skin microbiome is a new trend in the Chinese cosmetic industry,attracting the attention of both international players and Chinese niche brands alike.The sector is poised to take off but is still hindered by a lack of support regulations standardizing labeling and advertising claims and potential government supervision.However,on the flip side,there is some proof in principle supporting the commercial feasibility of these products.

摘要： Recently,two forces have permanently altered the technology landscape of China’s skincare sector and directly influenced its direction.The first is the biotechnology represented by life science,synthetic biology and gene technology in life science,affecting the innovation and development of cosmetics at the source in the field of biosynthesis of active ingredients and so on.The other is the skin science symbolized by evidence-based medicine and dermatologist.It exerts influence on the screening of efficacy raw material,clinical data and efficacy claim as well as new brand establishment.

摘要： Background Im paired sesitwity of he soin Mlush response bo miacin is one of the most rpicated findngs in patents with schizoprenia Howewer.prior studies have usaly focused on postonset psychusis,and ll is knowm about the dinical high-risk(CHR)phase of niacin senstity in psychosis Aims To proftle and compare the miacin flush responsge among CHR individuals(converters and non-coverters)patients with frstepso schinophrenia(FES)and healty controls(HCs).Methods Sensivily 1o ftour concentralions (0.1-0001M)of aqueous methylnicotinate was tested in 105 CHR individuals,57 patients with FES and 52 HCs.CHR individuals were further grouped as converters and non converters according to the 2-year follow-up outcomes.Skin flush response scores were rated on a 4-point scale.Results Of the 105 CHR individuals,21 individuals were lost during the study,leaving 84 CHR individuals;16(19.0%)converted to full psychosis at 2 years of fllow-up.Flush response scores identifed in the CHR samples were characterised as modest degree levels,intermediate between those of HC individuals and patients with FES.The flush responses in the CHR group mimicked the responses observed in the FES group at higher concentrations(0.01 M,0.1 M)and longer time points(15 min,20min);however,these became comparable vith the responses in the HC group at the shorter time points and at lower concentr ations.The converters exhibited lower mean flush response scores than the non-converters.Conclusions Attenuated niacin-induced flushing emerged during the early phase of psychosis.New devices should be developed and verified for objective quantification of skin responses in the CHR population.

摘要： In the World economy forum Global Challenge Insight Report titled “The Future of Jobs-Employment, Skills and Workforce Strategy for the Fourth Industrial Revolution (FIR) in 2016”, a new industrial revolution was predicted to occur in the near future. This is followed by the opinion that it would be mandatory to prepare for the FIR because it will definitely change people’s way of working, consuming and thinking. There is a controversy as to the potential of AI in health care. To date, however, remarkable achievements have been made in the field of medicine, particularly entailing dermatology. Therefore, this study explored the usefulness of the AI data in analyzing the skin in the era of the FIR. The current study finally included a total of 300 subjects, for whom a self-reporting questionnaire survey was performed between June 09 and July 18, 2020. The current study proposed the following hypothesis: The AI data might be useful in analyzing the skin in the era of the FIR. This hypothesis was accepted. In conclusion, the current study suggests that the AI data might be useful in analyzing the skin in the era of the FIR. But this deserves further study.

摘要： 欧莱雅已签署协议收购美国皮肤护理品牌Skinbetter Science,财务条款尚未披露。欧莱雅表示,Skinbetter Science是该国增长最快的护肤品牌之一。该公司总部位于亚利桑那州,具有医药背景,由制药行业专业人士Jonah Shacknai、Justin Smith和Seth Rodner于2016年共同创立。

摘要： This paper presents the current knowledge about the reconstruction of dinosaur heads. To reconstruct the dinosaur head, several features and functions of the head must be studied, namely osteology, musculature and soft tissue of the head, cranial kinesis, craniodental biomechanical characteristics, posterior part of the cranium, skin, and others. The main steps and points resulting from the study are the following. Firstly, the osteological remains of the head are studied for reconstruction according to the correct size and form in comparison with known remains belonging to the same family in case the remains were not complete. As the dinosaurs did not have facial muscles, their skin was pressed directly to the skull. The skin covering the large openings in front of the orbits of many dinosaurs probably bulged gently outward, and similarly, the jaw muscles bulged gently from the skull openings. Also, an investigation is performed to decide if sauropods were terrestrial or aquatic animals. Then, the individual characteristics of the head are examined in detail. These concern: 1) endocranial cast and nerves, 2) nostrils position, 3) the existence and kind of cheeks and lips, 4) Teeth types and function, 5) the palate shape and skin covering, 6) hyoid apparatus and tongues, 7) the details of the ear, 8) sclerotic rings and eyes, 9) skin and color. With the knowledge gathered about the various parts of the head in mind, decisions are made about the Amargasaurus (a sauropod) head in order to reconstruct a 3D, actual size head, as a worked example. Finally, the reconstruction procedure is described in detail.

摘要： BACKGROUND Langerhans cell sarcoma(LCS)is a rare malignancy with poor prognosis.LCS and chronic lymphocytic leukemia(CLL)/small lymphocytic lymphoma(SLL)can occur in the same diseased tissues,such as lymph nodes or skin.CASE SUMMARY A 48-year-old female Han Chinese patient was admitted for generalized lymph node enlargement for 6 years and abdominal distension for 1 wk.She was diagnosed with small B-cell lymphoma(stage IV)/CLL(Benet stage B)and received chemotherapy.She started oral ibrutinib in February 2019.She was hospitalized on June 11,2019,and a 1.5 cm×1.5 cm dark-red nodule with ulceration scalp lesion was found.Biopsy revealed LCS but without CLL/SLL.She was diagnosed with CLL/SLL(Binet stage C,Rai stage IV)accompanied by secondary histiocytic sarcomas and skin LCS and received cyclophosphamide,doxorubicin,vincristine,dexamethasone,and etoposide but developed severe cytopenia.She ultimately refused treatments and discharged spontaneously.She died on September 12,2019.The literature review showed that in patients with CLL/SLL,skin lesions of LCS are accompanied by CLL/SLL.This patient was different from the previously reported cases of skin LCS in patients with CLL/SLL.CONCLUSION In this patient,the skin lesion of LCS showed no concomitant CLL/SLL.

摘要： Various factors can induce cell degeneration by altering the phenotype and metabolism of cells.Mitochondria play an essential role in cellular homeostasis and function,rendering aging processes highly associated with mitochondrial function and status.Herein,we describe an aging-prone phenotype of murine skin cells caused by depletion of Rad6B(Ube2b),an E2 ubiquitin-conjugating enzyme.In this study,using Masson’s trichrome,we showed that loss of Rad6B causes physiological structure changes in mouse skin with age.In addition,a combination of western blotting experiments,transmission electron microscopy and employment of immunofluorescence staining revealed that depletion of Rad6B was characterized by an abnormal mitochondrial metabolic profile,including decreased mitochondrial biosynthesis and mitochondrial complex activities,increased ROS production and suppressed mitophagy resulting in metabolic disorders.Taken together,these results highlight an important relationship between Rad6B and skin senescence,suggesting that Rad6B plays an indispensable role in maintaining a healthy mitochondrial network and intracellular homeostasis.

摘要： AbstractThis paer uses a new method to deal with skin effect problem of tubular bus. Thenumericalformulars for calculating altemating current resistamce are deduced By means of one-dimensionSearch methodit detemnines critical thickness referred tominimum alternating current resistance ofthe bus. The satisfactory calculated results also given in the paper.

摘要： 本发明涉及SKIN基因沉默质粒和包含该质粒的转化的植物细胞。所述SKIN基因沉默质粒包含：启动子，两个DNA片段，所述两个DNA片段从来源于SKIN1或SKIN2cDNA的一个DNA片段中获得并以正义和反义的方向布置，以及插在所述两个DNA片段之间的第三个DNA片段。SKIN是水稻生长和产量的负调节子，且内源SKIN表达的减少增加了水稻的产量。本发明还涉及包含所述SKIN基因沉默质粒的转化的植物细胞以及转基因植物。

摘要： 本发明涉及基于镜像虚拟和Skinner强化学习的个性化MI‑EEG训练与采集方法，该方法将康复治疗领域的镜像疗法和Skinner强化学习理论融合到MI‑EEG的训练与采集过程当中。在训练模式中设计个性化视听联合刺激，在一种较为放松的状态下通过健侧手佩戴数据手套并执行张/握动作，利用计算机串口实时读取并解码健侧手部动作的数据，进而钳制采集界面中镜像虚拟患侧手模型的动作。使受试者通过自身健侧手的动作激励诱导镜像虚拟手的运动，加强大脑运动功能区镜像神经元的电活动,并基于Skinner强化学习理论设计闭环脑电采集与控制模式检验训练效果，同时，通过Skinner在线奖励反馈，进一步增强内动机，提高MI‑EEG质量。本发明操作简单，以期取得更好的实际应用。

摘要： 本发明公开了一种基于Skinner操作条件反射自动机的机器人轨迹跟踪方法，涉及移动机器人轨迹跟踪领域，具体涉及一种基于Skinner操作条件反射自动机的机器人轨迹跟踪方法。本发明首先建立机器人的操作和状态集合，并建立相应的状态到操作的概率集合，并令其符合均匀分布；然后，随机选择一个操作，计算相应的位置变化，进而根据距离目标轨迹的距离计算取向函数，根据取向函数值按照操作条件反射理论调整动作概率分布，计算系统熵；当系统熵趋于最小值时，学习结束。此时概率矩阵为最优。本发明能够很好地模拟人及动物的操作条件反射行为，提高机器人智能水平，是其具备较强的自学习、自组织、自适应能力，自主条件参数，成功进行轨迹跟踪。

摘要： 本发明涉及了一种基于Skinner操作条件反射原理的机器人避障导航方法。首先，建立机器人的动作集合概率，并令其符合均匀分布；然后，随机选择一个动作，计算相应的位置变化，进而根据与障碍及目标点距离计算出新位置对应的负理想度，并由此得出取向函数值，根据取向函数值按照操作条件反射理论调整动作概率分布，计算系统熵；当系统熵趋于最小值时，选择概率最大动作所指角度前行；重复学习过程，直至抵达目的地。本发明能够很好地模拟人及动物的操作条件反射行为，提高机器人的智能水平，使其具备较强的自学习、自组织、自适应能力，能够在无导师信号的情况下自主探索环境，成功避障导航。

摘要： 本发明公开了一种基于Skinner概率自动机的图像误匹配对去除方法，包括：进行图像匹配，得到匹配对；确定匹配结果的Skinner概率自动机数学模型；从匹配对中按照概率随机抽取匹配对，并且求出图像间的基础矩阵，然后将此基础矩阵带入所有匹配对，根据判决函数求出每个匹配对之间的极对距离和平均极对距离；根据权重调节函数、每个匹配对的极对距离和平均极对距离对每个匹配对进行权重的调整，并且计算每个匹配对的提取概率；判断当前基础矩阵是否具有最多正确匹配对数目，并结合三个判断条件控制算法迭代过程。本发明引入仿生学和认知心理学，在缺乏错匹配概率先验知识的情况下提出了三种迭代终止条件，提高了算法的自主性。

摘要： 本发明涉及基于镜像虚拟和Skinner强化学习的个性化MI-EEG训练与采集方法，该方法将康复治疗领域的镜像疗法和Skinner强化学习理论融合到MI-EEG的训练与采集过程当中。在训练模式中设计个性化视听联合刺激，在一种较为放松的状态下通过健侧手佩戴数据手套并执行张/握动作，利用计算机串口实时读取并解码健侧手部动作的数据，进而钳制采集界面中镜像虚拟患侧手模型的动作。使受试者通过自身健侧手的动作激励诱导镜像虚拟手的运动，加强大脑运动功能区镜像神经元的电活动,并基于Skinner强化学习理论设计闭环脑电采集与控制模式检验训练效果，同时，通过Skinner在线奖励反馈，进一步增强内动机，提高MI-EEG质量。本发明操作简单，以期取得更好的实际应用。

摘要： 本发明公开了一种基于Skinner操作条件反射自动机的机器人轨迹跟踪方法，涉及移动机器人轨迹跟踪领域，具体涉及一种基于Skinner操作条件反射自动机的机器人轨迹跟踪方法。本发明首先建立机器人的操作和状态集合，并建立相应的状态到操作的概率集合，并令其符合均匀分布；然后，随机选择一个操作，计算相应的位置变化，进而根据距离目标轨迹的距离计算取向函数，根据取向函数值按照操作条件反射理论调整动作概率分布，计算系统熵；当系统熵趋于最小值时，学习结束。此时概率矩阵为最优。本发明能够很好地模拟人及动物的操作条件反射行为，提高机器人智能水平，是其具备较强的自学习、自组织、自适应能力，自主条件参数，成功进行轨迹跟踪。

摘要： 本发明涉及SKIN基因沉默质粒和包含该质粒的转化的植物细胞。所述SKIN基因沉默质粒包含：启动子，两个DNA片段，所述两个DNA片段从来源于SKIN1或SKIN2cDNA的一个DNA片段中获得并以正义和反义的方向布置，以及插在所述两个DNA片段之间的第三个DNA片段。SKIN是水稻生长和产量的负调节子，且内源SKIN表达的减少增加了水稻的产量。本发明还涉及包含所述SKIN基因沉默质粒的转化的植物细胞以及转基因植物。

摘要： 本发明涉及了一种基于Skinner操作条件反射原理的机器人避障导航方法。首先，建立机器人的动作集合概率，并令其符合均匀分布；然后，随机选择一个动作，计算相应的位置变化，进而根据与障碍及目标点距离计算出新位置对应的负理想度，并由此得出取向函数值，根据取向函数值按照操作条件反射理论调整动作概率分布，计算系统熵；当系统熵趋于最小值时，选择概率最大动作所指角度前行；重复学习过程，直至抵达目的地。本发明能够很好地模拟人及动物的操作条件反射行为，提高机器人的智能水平，使其具备较强的自学习、自组织、自适应能力，能够在无导师信号的情况下自主探索环境，成功避障导航。

摘要： 本发明公开了一种基于Skinner概率自动机的图像误匹配对去除方法，包括：进行图像匹配，得到匹配对；确定匹配结果的Skinner概率自动机数学模型；从匹配对中按照概率随机抽取匹配对，并且求出图像间的基础矩阵，然后将此基础矩阵带入所有匹配对，根据判决函数求出每个匹配对之间的极对距离和平均极对距离；根据权重调节函数、每个匹配对的极对距离和平均极对距离对每个匹配对进行权重的调整，并且计算每个匹配对的提取概率；判断当前基础矩阵是否具有最多正确匹配对数目，并结合三个判断条件控制算法迭代过程。本发明引入仿生学和认知心理学，在缺乏错匹配概率先验知识的情况下提出了三种迭代终止条件，提高了算法的自主性。