Safety

摘要： BACKGROUND Pleural effusions occur for various reasons,and their diagnosis remains challenging despite the availability of different diagnostic modalities.Medical thoracoscopy(MT)can be used for both diagnostic and therapeutic purposes,especially in patients with undiagnosed pleural effusion.AIM To assess the diagnostic efficacy and safety of MT in patients with pleural effusion of different causes.METHODS Between January 1,2012 and April 30,2021,patients with pleural effusion underwent MT in the Department of Respiratory Medicine,The Second Affiliated Hospital of Xi’an Jiaotong University(Shaanxi,China).According to the discharge diagnosis,patients were divided into malignant pleural effusion(MPE),tuberculous pleural effusion(TBPE),and inflammatory pleural effusion(IPE)groups.General information,and tuberculosis-and effusion-related indices of the three groups were analyzed.The diagnostic yield,diagnostic accuracy,performance under thoracoscopy,and complications of patients were compared among the three groups.Then,the significant predictive factors for diagnosis between the MPE and TBPE groups were analyzed.RESULTS Of the 106 patients enrolled in this 10-year study,67 were male and 39 female,with mean age of 57.1±14.184 years.Among the 74 thoracoscopy-confirmed patients,41(38.7%)had MPE,21 had(19.8%)TBPE,and 32(30.2%)were undiagnosed.Overall diagnostic yield of MT was 69.8%(MPE:75.9%,TBPE:48.8%,and IPE:75.0%,with diagnostic accuracies of 100%,87.5%,and 75.0%,respectively).Under thoracoscopy,single or multiple pleural nodules were observed in 81.1%and pleural adhesions in 34.0%with pleural effusions.The most common complication was chest pain(41.5%),followed by chest tightness(11.3%)and fever(10.4%).Multivariate logistic regression analyses showed effusion appearance[odds ratio(OR):0.001,95%CI:0.000-0.204;P=0.010]and carcinoembryonic antigen(OR:0.243,95%CI:0.081-0.728;P=0.011)as significant for differentiating MPE and TBPE,with area under the receiver operating characteristic curve of 0.977(95%CI:0.953-1.000;P<0.001).CONCLUSION MT is an effective,safe,and minimally invasive procedure with high diagnostic yield for pleural effusion of different causes.

摘要： BACKGROUND Little is known about the safety and efficacy of using two or more biologics for the treatment of immune-mediated diseases,including Crohn’s disease(CD).CASE SUMMARY This case report and narrative review demonstrate the potential safety of dual biologic therapy(DBT)in a 45-year-old female with two separate immunemediated diseases.She had a history of multiple sclerosis for which she was receiving treatment with ocrelizumab,and she had been recently diagnosed with CD after presenting with diarrhoea.The CD diagnosis was confirmed radiologically,endoscopically,histologically,and biochemically.The patient received treatment with vedolizumab,a gut-specific inhibitor of theα4β7 integrin on leukocytes.No adverse reactions were observed for the duration of treatment.The safety of ocrelizumab and vedolizumab for the treatment of different immune-mediated diseases was demonstrated.CONCLUSION DBT may be a safe and effective option for the treatment of refractory disease or multiple immunemediated diseases.Newer biologics,which have improved safety profiles and gut specificity,may provide promising avenues for treatment.However,caution must be exercised in the appropriate selection of biologics given their inherent immunosuppressive properties,side effects,and efficacy profiles.Current evidence suggests that biologic therapy is not associated with a worse prognosis in patients with coronavirus disease 2019,but treatment decisions should be made in a multidisciplinary setting.Further research from controlled trials is needed to better understand the safety profile of DBT in CD.The immunopathological mechanisms underlying DBT also remain to be clarified.

摘要： With the ever-growing application of lithium-ion batteries(LIBs), their fast-charging technology has attracted great interests of scientists. However, growth of lithium dendrites during fast charge of the bat teries with high energy density may pose great threats to the operation and cause serious safety issues Herein, we prepared a functional separator with an ultra-thin(20 nm) layer of Au nanoparticles deposited by evaporation coating method which could regulate growth direction and morphology of the lithium dendrites, owing to nearly zero overpotential of lithium meal nucleation on lithiated Au. Once the Li den drites are about to form on the graphite anode during fast charging(or lithiation), they plate predomi nantly on the Au deposited separator rather than on the graphite. Such selective deposition does no compromise the electrochemical performance of batteries under normal cycling. More importantly, i enables the better cycling stability of batteries at fast charge condition. The Li/Graphite cells with Au nanoparticles coated separator could cycle stably with a high areal capacity retention of 90.5% over 95 cycles at the current density of 0.72 m A cm^(-2). The functional separator provides an effective strategy to adjust lithium plating position at fast charge to ensure high safety of batteries without a compromise on the energy density of LIBs.

摘要： Automation of aircraft instrument displays enhances flight safety, but it also increases complexity and pilot workload. Executing changes in flight plan, navigation or communication during flight using flight instrument switches often increases pilots’ workload and this may also cause distraction that adds potential risks to flight safety. This study compares the conventional avionics panel and touchscreen avionic panel to find out the least distractive panel for the pilots. Thirty simulated flights using four different pilots were carried out;and aircraft speed, altitude and heading parameters using both avionics systems were observed to study the operational efficiency and pilot distraction resulted from each of the avionic systems. The distraction was examined by a parameter analysis based on the Mean Squared Error (MSE) mathematical model and visually by recording videos of each simulated flight. The results indicate that the touchscreen system is more efficient and less erroneous for the aircraft in maintaining the parameters as compared with the conventional system. There is also a clear relationship between task completion time and disruption level on the parameters control.

摘要： Tyre related crashes accounted for 8.38%,9.24%,7.40%,7.24%,6.73%,6.10%of total crashes on Nigerian roads in year 2011,2012,2013,2014,2015 and 2016 respectively,making appraisal of conditions of tyres very crucial.Data on the use of tyres in the country are not available hence,the need to conduct a survey on this aspect.The aim of the research is to collate data to assess the conditions of tyres for informed decision on road safety.The objectives are to ascertain the level of awareness on tyre usage and identify the condition of tyres being used.Questionnaires were administered to private,commercial and government drivers nationwide by the Federal Road Safety Corps(FRSC).A total of 124,510 tyres on 30,242 vehicles were checked.Forty percent(40%)of the total tyres were expired out of which 44%were for commercial vehicles.Thirty percent(30%)of total tyres surveyed had correct pounds per square inch(PSI)as many of the tyres were either under or over inflated.Sixty-five percent(65%)of the tyres met thread depth of 1.6 mm while 8%of the tyres had bumps.Twenty-three percent(23%)of the drivers are unaware of tyre information.FRSC used this in developing strategies to educate the public on better usage of tyres.

摘要： Highway is an essential facility that led to both economic success and quality of life.Maintenance is necessary to ensure that highway will able to continue to carry out its functions.The rutting of asphalt pavement structures during their exploitation is considered to be one of the main problems in the entire world.This kind of pavement distress makes a negative impact to the exploitation characteristics of the asphalt pavement to the residual life of pavement structure,also to the safety and quality of the traffic.The main purpose of this review is to define the effects of rutting on roads safety.

摘要： Background:Yangxin Dawayimixike honey paste(YDHP)is a representative traditional Chinese medicine,and its main function is curing angina pectoris,palpitation and neurasthenia.However,it is unclear whether YDHP can suppress the development of atherosclerosis.The aim of this study was to validate the potential application of YDHP in atherosclerosis therapy and search for its potential mechanisms.Methods:Seven-week-old ApoE^(-/-)mice were randomly divided into a normal group fed a normal diet,an atherosclerosis model group fed a high-fat diet,YDHP groups fed a high-fat diet mixed with different doses of YDHP and positive control groups fed a high-fat diet mixed with atorvastatin or rosuvastatin.After feeding for 10 weeks,body weight,blood lipids,liver and kidney function indexes,serum inflammatory cytokines and atherosclerotic plaque areas were measured.Serum metabolic profiles were detected by an automatic biochemical analyser.Serum inflammatory cytokines were quantified by enzyme-linked immunosorbent assay kits.Atherosclerotic plaque areas were analysed using Oil Red O staining.Results:The YDHP(200,400 and 800 mg/kg/d)treated groups showed reduced serum levels of low density lipoprotein-cholesterol(P<0.05,when 200 or 400 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 800 mg/kg/d of YDHP group compared with the atherosclerosis model group),total cholesterol(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and triglyceride(P<0.01),however,elevated serum levels of high-density lipoprotein cholesterol(P<0.01)compared to the atherosclerosis model group.YDHP inhibited the area of atherosclerotic lesions.In addition,YDHP suppressed the levels of serum inflammatory cytokines such as interleukin 6(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and tumor necrosis factorα(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group).Conclusion:Our study demonstrated that YDHP showed considerable activity in alleviating the formation of atherosclerotic plaques in ApoE^(-/-)mice by reducing blood lipids and exerting anti-inflammatory activity.

摘要： BACKGROUND Hepatitis C virus(HCV)treatment has undergone major changes in recent years.Previous interferon-based therapies have been replaced by oral direct-acting antivirals(DAA)regimens,with high sustained virologic response(SVR)rates,and a lower incidence of adverse events(AEs).AIM To evaluate the efficacy and safety of DAAs for HCV treatment in subjects from two tertiary university centers in Brazil.METHODS This is a multicenter retrospective cohort study of 532 patients with chronic hepatitis C(CHC),undergoing treatment with interferon-free regimens from November 2015 to November 2019.The therapeutic regimen was defined by the current Brazilian guidelines for HCV management at the time of treatment.Demographic,anthropometric,clinical,and laboratory variables were evaluated.SVRs were assessed at 12 to 24 wk after therapy by intention-to-treat(ITT),and modified ITT(m-ITT)analysis.AEs and serious adverse events(SAEs)were registered.In the statistical analysis,a P value of<0.05 was considered significant.RESULTS The mean age was 56.88 years,with 415(78.5%)being HCV genotype 1,followed by genotype 3(20.1%).Moreover,306(57.5%)subjects had cirrhosis,and a third of them had decompensated cirrhosis.Sofosbuvir(SOF)plus daclatasvir±ribavirin was the most frequently used treatment(66.9%),followed by SOF plus simeprevir(21.2%).The overall ITT SVR was 92.6%(493/532),while the m-ITT SVR was 96.8%(493/509).Variables associated with treatment failure via ITT evaluation were hepatic encephalopathy(OR:4.320;95%CI:1.920-9.721,P=0.0004),presence of esophageal varices(OR:2.381;95%CI:1.137-4.988,P=0.0215),previous portal hypertensive bleeding(OR:2.756;95%CI:1.173-6.471,P=0.02),higher model for end-stage liver disease scores(OR:1.143,95%CI:1.060–1.233,P=0.0005),lower serum albumin levels(OR:0.528,95%CI:0.322-0.867,P=0.0115),higher serum creatinine(OR:1.117,95%CI:1.056-1.312,P=0.0033),and international normalized ratio(INR)levels(OR:5.542,95%CI:2.023-15.182,P=0.0009).AEs were reported in 41.1%(211/514)of patients,and SAEs in 3.7%.The female gender,higher body mass index,esophageal varices,higher INR values,and longer treatment duration were independently associated with AE occurrence.CONCLUSION Treatment with oral DAAs attains a high SVR rate,with fewer SAEs in a real-life cohort of subjects with CHC,from two tertiary university centers in Brazil.

摘要： Objective:To investigate the feasibility and safety of achieving total enteroscopy by consecutive bidirectional double-balloon enteroscopy(DBE)procedures.Methods:The demographic data,indication,initial insertion route,examination time for each insertion and the entire procedure,total enteroscopy rate,diagnostic yield and adverse events of patients who attempted to achieve total enteroscopy by consecutive bidirectional DBE procedures from January 2014 to December 2019 were retrospectively analyzed.

摘要： The application of internet in the industrial field has become an inevitable trend in modern society.In the actual operation,there are possible safety risks.To ensure the system’s proper operation,technicians are required to resolve the issues.In this context,the author thoroughly integrated with the present industrial development situation,examined the use of 5G technology in industrial internet security,and desired to leverage the advantageous benefits of 5G technology to boost industrial development.Due to the numerous benefits of 5G technology in security applications,we conducted an in-depth investigation and described it from the perspectives of relevant concepts,security,and security application guarantee measures,with the goal of achieving the goal of safe industrial internet operation.

摘要： Introduction Both international and national safety standards oflithium ion battery used for mobile phones areavailable.Battery manufacturers certify their cell safetyaccording to international standards such as UL1642,UL2054and IEC61960-1/2. Some selected key safety tests areincluded in most of cell manufacturers' QC proceduressince the international standard certification fallshort of what is required to ensure consumer safety.Therefore,some cell manufacturers see this shortcoming and evenconduct cell safety testing in excess of ULrequirement,though many do not. It is extremely important thatcell users evaluate the cell safety thoroughly beforetheirequipment is marketed. Large lithium ion batteryindustries are growing fast, driven by such as E-bikeand EVapplications. Hazardous conditions for lithium ionbatteries occur when EV drives. However, much moreattention is now on the battery long-term performancetargets than on the safety standards due to the highperformance requirement of EV batteries. This isreflected by the fact that safety and abuse testprotocols ofEV cells are still under developing world widely.

摘要： 本实用新型公开了一种汽车DC‑DC SAFETY MOS驱动电路，涉及电源转换器技术领域。本实用新型包括三个三极管Q1、Q2、Q3和开关管Q4，三极管Q1的发射极接驱动电压V_drive，基极通过分压电阻R3接三极管Q3的基极，集电极依次通过二极管D1、分压电阻R4接三极管Q3的集电极；三极管Q3的集电极接开关管Q4的栅极，发射极接开关管Q4的漏极；三极管Q2的集电极通过分压电阻R2接在分压电阻R3和二极管D1之间，发射极接地，基极接驱动控制信号DRV_CTRL；三极管Q1的发射极与基极之间接有分压电阻R1。本实用新型通过三个三极管和一个开关管的组合能够有效将开关管的栅极拉到地，且减小源极‑栅极间的电压应力，有效延长开关管的使用寿命。