Safe

摘要： Pu-erh ripen tea becomes popular worldwide owing to its unique taste and aroma.In the present study,volatile compounds from Pu-erh ripen tea were extracted using a solvent assisted flavor evaporation(SAFE)and analyzed with a gas chromatography-mass spectrometry(GC-MS)and a gas chromatography olfactometry(GC-O).Results demonstrated that 58 major volatile compounds and 24 aroma active substances of Pu-erh ripen tea were identified by GC-MS and GC-O analysis.Among volatile compounds identified,methoxyphenyl compounds were considered as the dominate compounds in the aroma of Pu-erh ripen tea.Further investigation showed that 6 methoxybenzenes were responsible for the aging aroma in Pu-erh ripen tea;α-ionone,3,4-dimethoxytoluene,1,3-dimethoxybenzene,etc.were responsible for the wood-like aroma.Linalool,α-terpineol,α-ionone,β-ionone,and benzeneacetaldehyde were responsible for the floral odor.Compared the odor detection threshold(ODT)among the 8 methoxyphenyl compounds in water,1,2,3-trimethoxybenzene showed the highest ODT,followed by 3,4-dimethoxyphenol.1,3-dimethoxybenzene(105μg/L)and 1,2,3-trimethoxy-5-methylbenzene(100μg/L)were present at relatively low odor threshold values.The result indicated that methoxyphenyl compounds play a vital role in the unique flavor of Pu-erh ripen tea.

摘要： BACKGROUND Three-dimensional(3D) laparoscopic technique has gradually been applied to the treatment of carcinoma in the remnant stomach(CRS), but its clinical efficacy remains controversial.AIM To compare the short-term and long-term results of 3D laparoscopic-assisted gastrectomy(3DLAG) with open gastrectomy(OG) for CRS.METHODS The clinical data of patients diagnosed with CRS and admitted to the First Medical Center of Chinese PLA General Hospital from January 2016 to January 2021 were retrospectively collected. A total of 84 patients who met the inclusion and exclusion criteria were enrolled. All their clinical data were collected and a database was established. All patients were treated with 3DLAG or OG by experienced surgeons and were divided into two groups based on the different surgical methods mentioned above. By using outpatient and telephone follow-up,we were able to determine postoperative survival and tumor status. The postoperative short-term efficacy and 1-year and 3-year overall survival(OS) rates were compared between the two groups.RESULTS Among 84 patients with CRS, 48 were treated with OG and 36 with 3DLAG. All patients successfully completed surgery. There was no significant difference between the two groups in terms of age, gender, body mass index, ASA score,initial disease state(benign or malignant), primary surgical anastomosis method,interval time of carcinogenesis, and tumorigenesis site. Patients in the 3DLAG group experienced less intraoperative blood loss(188.33 ± 191.35 mL vs 305.83 ± 303.66 mL;P =0.045) and smaller incision(10.86 ± 3.18 cm vs 20.06 ± 5.17 cm;P < 0.001) than those in the OG group. 3DLAGC was a more minimally invasive method. 3DLAGC retrieved significantly more lymph nodes than OG(14.0 ± 7.17 vs 10.73 ± 6.82;P = 0.036), whereas the number of positive lymph nodes did not differ between the two groups(1.56 ± 2.84 vs 2.35 ± 5.28;P = 0.413). The complication rate(8.3% vs 20.8%;P = 0.207) and intensive care unit admission rate(5.6% vs 14.5%;P = 0.372) were equivalent between the two groups. In terms of postoperative recovery, the 3DLAGC group had a lower visual analog score, shorter indwelling time of gastric and drainage tubes, shorter time of early off-bed motivation, shorter time of postoperative initial flatus and initial soft diet intake, shorter postoperative hospital stay and total hospital stay, and there were significant differences, showing better short-term efficacy. The 1-year and 3-year OS rates of OG group were 83.2% [95% confidence interval(CI): 72.4%-95.6%] and 73.3%(95%CI: 60.0%-89.5%)respectively. The 1-year and 3-year OS rates of the 3DLAG group were 87.3%(95%CI: 76.4%-99.8%) and 75.6%(95%CI: 59.0%-97.0%), respectively. However, the 1-year and 3-year OS rates were similar between the two groups, which suggested that long-term survival results were comparable between the two groups(P = 0.68).CONCLUSION Compared with OG, 3DLAG for CRS achieved better short-term efficacy and equivalent oncological results without increasing clinical complications. 3DLAG for CRS can be promoted safely and effectively in selected patients.

摘要： BACKGROUND Patients with lupus nephritis(LN)typically undergo long-term treatment with glucocorticoids(GCs)and immunosuppressants.There is a growing demand for optimal therapy with better remission results and fewer side effects.Sustained traditional Chinese medicine(TCM)might be quite valuable for multitarget therapy,reducing the total dosage of GCs and minimizing the side effects of immunosuppressants.AIM To evaluate whether Dan Bai Xiao Formula(DBXF)can reduce the exposure to GCs and cyclophosphamide(CYC)and to assess the efficacy and safety of DBXF for the resolution of proteinuria and hematuria in children with LN.METHODS A 24-wk pilot study was conducted at Beijing Children’s Hospital.Children with active LN were divided into either a TCM group or a control group.Children in the TCM group received DBXF combined with GCs and CYC,and the ones in the control group received GCs and CYC every 4 wk for 24 wk.The primary endpoints of this trial were urinary protein excretion of0.05).The urine red blood cell count and urine protein level were significantly lower in the TCM group than in the control group at weeks 4,12,and 24(P<0.05).Furthermore,patients in the TCM group had a lower proportion of methylprednisolone pulses than those in the control group(1.30±1.41 vs 3.05±2.02,P<0.0001).The ending GC dose was significantly lower in the TCM group than in the control group(P<0.001).Moreover,more hepatic function damage,gastrointestinal adverse effects,and hypertension were observed in the control group than in the TCM group(P<0.05).CONCLUSION The findings suggest that DBXF treatment is effective and safe as a supplementary therapy for LN and is superior to routine GC and CYC therapy.DBXF containing combination treatment possibly results in a faster resolution of proteinuria and hematuria,smoother GC reduction,fewer methylprednisolone pulses,and fewer adverse events.

摘要： 2005年,世界海关组织通过了《全球贸易安全与便利标准框架》(以下简称《SAFE标准框架》),建立了现代化供应链安全标准,其目标不仅是建立更为安全的世界贸易体制,同时也旨在促进海关和商界之间形成更为紧密的伙伴关系。我国于2005年签署《SAFE标准框架》实施意向书,并将其中的"经认证的经营者"(以下简称"AEO")制度转化为国内法。截至2020年8月,已有171个成员签署实施该框架的意向书。《SAFE标准框架》带来的切实利益,让企业产生认同感。

摘要： 经过改装的专业越野车较普通汽车底盘更高、车架更大,且拥有巨型尺寸的轮胎和大排量发动机,即使不启动也能给人强烈的视觉震撼。这种车型的越野能力堪称众车之最。本期介绍的HSP RAPIDLX SAFE 1/8电动大脚车就是这样一款车模,虽定位入门级产品,却具有优异的越野性能,很适合新手使用。

摘要： 南方电网云南玉溪供电局创新性提出了“SAFE”模型,从思想引领,人才培养、风险防控、落地执行等方面着手,深度推进党建工作与安全生产深度融合,坚决打好安全生产“翻身战”。

摘要： 未来股权简单协议(SAFE)是一种新兴股权众筹形式,由于其能够适应高成长型初创企业的投融资需要而在美国资本市场流行.我国未来可尝试引入SAFE机制作为金融创新手段,但需要注意其内在风险.应采取积极审慎的态度,从股权众筹平台的准入和征信制度、所提供的格式合同文本、投资者的教育机制、信息披露要求等方面制定和完善相关法律法规,进行必要的监管,以严格控制其风险,尽量减少其负面影响,使其既有助于小微初创企业融资,又不致损害投资者的利益.

摘要： BACKGROUND Gallbladder polyps are one indication for cholecystectomy,but this procedure carries some disadvantages,including the potential for severe injury and high risk of post-operative complications.Laparoscopy combined with endoscopic surgery is a minimally invasive treatment option.We herein report a young patient with a gallbladder polyp who was successfully discharged from the hospital after laparoscopic-assisted endoscopy.This procedure may offer an alternative in the management of such lesions.CASE SUMMARY A 24-year-old female patient was hospitalized primarily for a gallbladder polyp.Due to the surgical risk associated with cholecystectomy and the low postoperative quality of life,the woman underwent laparoscopic-assisted transumbilical gastroscopy for gallbladder-preserving polypectomy under endotracheal intubation and general anaesthesia.The operation went smoothly.CONCLUSION We conclude laparoscopic-assisted transumbilical gastroscopy for gallbladderpreserving polypectomy is a safe and effective technique for the treatment of gallbladder polyps.

摘要： BACKGROUND Endoscopic resection of non-invasive lesions is now the standard of care for lesions in the GI tract.However,resection techniques require extensive training,are not available in all endoscopy centers and are prone to complications.Endoscopic mucosal ablation(EMA)is a combination of resection and ablation techniques and it may offer an alternative in the management of such lesions.CASE SUMMARY In this case series we report the successful treatment of three flat colonic polyps using the EMA technique.Two lesions were treatment naïve and 1 was a recurrence after an endoscopic mucosal resection.The sizes ranged from 2 to 4 cm.All three polyps were ablated successfully with no immediate or delayed complications.The recurrence rate at 1 year of follow up was 0%.CONCLUSION Based on this initial experience,we conclude that EMA is a safe and effective technique for the treatment of non-invasive colonic polyps when endoscopic resection techniques are not available.

摘要： 本发明涉及一种故障安全型Fail‑Safe地坑架车机控制系统。包括信号检测单元、信号采集单元、安全链路、评估处理单元和动作执行单元，信号检测单元采用Fail‑Safe型的三触点行程开关；信号采集单元采用Fail‑Safe型数字量输入模块；评估处理单元采用Fail‑Safe型可编程逻辑控制器F‑CPU；动作执行单元采用Fail‑Safe型数字量输出模块；Fail‑Safe型的三触点行程开关，其中一个常闭触点和一个常开触点采用异步接线方式接入Fail‑Safe型数字量输入模块中，另外一个常闭触点接入安全链路中，Fail‑Safe型数字量输入模块采用1oo2的异步信号接线方式，Fail‑Safe型数字量输出模块采用双线圈输出形式，安全链路包括两级三层。本发明极大的增强了安全型地坑架车机设备的安全性能，能够满足当前设备使用方对地坑架车机安全性能的要求。

摘要： 本发明提供一种水稻非胚乳表达启动子SAFES3及其应用。本发明还提供了含有该启动子的表达盒和作物表达载体。具体而言，本发明将上述启动子应用在作物基因工程中。本发明提供的启动子可以特异地驱动外源基因在水稻非胚乳组织中表达，并利用非胚乳表达启动子的特性，充分发挥转基因育种的优势，培育出更多更好的新品种。经实验验证，本发明的启动子能够驱动外源基因在水稻的非食用部位(非胚乳)表达，而不会引起食用部位表达。这种启动子一旦得到广泛应用，非常便于推广，而且会尽可能地保证稻米的质量不受转基因的影响，更有利于消除民众对转基因产品的疑虑。

摘要： 本发明涉及一种分离出的胚乳不表达启动子SAFES6及其应用。具体地，本发明提供了能够在植物组织中而不在胚乳中转录异源核酸序列的启动子SAFES6及制备和使用该启动子的方法。本发明还涉及含有该启动子的表达盒、重组表达载体和获得相应转基因植物的方法。本发明所提供的水稻启动子SAFES6能够调控基因在植株中非胚乳部位集中表达，而在胚乳中不表达，本发明利用该启动子在不改变植物胚乳性状情况下改良植物生长特性，改善水稻的生长性能，同时降低了水稻的食用安全风险，进而可以获得理想的转基因植株，有助转基因水稻的商业推广。

摘要： 本发明提供一种水稻茎叶强表达启动子SAFES7及其应用。本发明从水稻中发现、分离并鉴定了该启动子的序列。具体而言，本发明通过DNA重组技术，构建由该水稻茎叶强表达启动子SAFES7驱动GUS报告基因的转化载体，通过模式作物的转化实验，鉴定了该启动子的特点是，驱动目的基因在茎、叶、叶鞘等组织中表达，而在根、胚、胚乳细胞中不表达。对这类启动子的研究和应用，不仅有助于阐述相关基因的生物学功能，而且在作物基因工程中使用此类启动子为作物转基因安全性研究提供了材料基础和多种选择。

摘要： 本发明提供一种作物种子不表达启动子SAFES5及其应用。本发明还提供了含有该启动子的表达盒和作物表达载体。具体而言，本发明将上述启动子应用在作物基因工程中。本发明提供的启动子可以特异地驱动外源基因在作物叶、绿色组织或其他非种子组织中表达。因此，如果利用本发明的启动子对作物进行改造，可以限制抗虫等重要基因的表达位置，既能提高外源基因利用效率，同时也避免了异源毒蛋白在食用部位的表达和积累，降低过敏概率，减少社会和公众的担忧。

摘要： 本发明提供了一种水稻胚乳不表达启动子SAFES2及其分离方法与应用。本发明的发明人发现、提取并鉴定了日本晴水稻中一段具有转录调控活性的DNA序列，命名为启动子SAFES2或SAFES2。该启动子的核苷酸序列为序列表中SEQ ID No.1中所示序列或为该序列的同源衍生物。本发明利用作物双元表达载体pCAMBIA1391，将启动子SAFES2构建于GUS报告基因上游，构建重组表达载体，通过农杆菌介导转化水稻愈伤组织再生水稻植株，GUS染色实验证实该启动子是胚乳不表达启动子。采用本发明的启动子与具有提高植株生长特性的基因配合使用，可以在提高植株根、茎、叶等躯干部位性状的同时，避免对植株胚乳部分带来任何不良影响，具有显著的应用价值和远期前景。

摘要： 本发明提供了一种基于SAFE‑GC‑MS技术测定鸡汤中的风味物质的方法及其应用，对于挥发性风味物质的特殊性，采用SAFE‑GC‑MS方法测定鸡汤中的香气成分，再通过GC‑O‑H方法对高挥发性香味化合物进行有效检测和评价，同时能与AEDA产生互补的信息，辅助研发清炖鸡汤膏状香精。将所得的分析结果应用到香精的开发中，使得有效物质间能够产生协同作用，对研发思路和过程给到帮助和支持。

摘要： 本发明公开了一种基于SPME和SAFE香气化合物的提取方法，步骤一）SPME提取：S1：选取4份牛油样品，分别用去离子水稀释至合适浓度后放入橡胶样品瓶中暂存；S2：使用SPME针管穿透样品瓶的隔垫；S3：推动手柄使纤维头伸出针管，萃取时间控制在10‑35分钟；S4：缩回纤维头，同时将针管退出顶空瓶中；S5：萃取完毕后，将SPME针管插入全二维气相色谱仪的进样口中，得到被测牛油样品的全二维气相色谱仪质谱分离图；步骤二）SAFE提取；S1:加料，蒸馏；S2：蒸发完后，将接收瓶取出，于背光处室温自然融化后，加入无水硫酸钠干燥12小时，将萃取液过滤至圆底烧瓶中即可，本发明提出的SPME和SAFE两种提取方式的结合可以更加全面，精准地测定和提取牛油中的各种香气化合物。

摘要： 本发明提供一种fail‑safe失效安全系统,方法,储存器及汽车，分别设置第一处理模块和第二处理模块，用于对车辆系统分别进行第一安全层级检测和第二安全层级检测，同时，进一步设置转换电路用于控制关断通道，当发生异常时通过关断通道切断车身CAN单元的通讯，并通过反馈通道，向所述第二处理模块反馈关断状态为已成功关断，从而确保每一个环节的故障和故障处理机制都能有效被监管，在发生异常时能及时让车身CAN通信实现Fail‑Safe的静默要求，最终保障系统信息的有效性和驾驶的安全性。

摘要： 本发明提供一种fail‑safe控制电压产生电路，用于为GPIO电路提供多种控制电压，包括第一控制电压源接口、第二控制电压源接口、第三控制电压源接口、第一至第十一PMOS晶体管、第一至第六NMOS晶体管，其中：第一控制电压源接口在芯片正常工作时输出与芯片内部供电电源的输出电压相等的控制电压，在芯片断电时输出小于或等于总线上其他芯片电压20％的控制电压；第二控制电压源接口在芯片正常工作时输出与芯片内部供电电源的输出电压相等的控制电压，在芯片断电时输出与总线上其他芯片电压相等的控制电压；第三控制电源原接口在芯片正常工作时输出零电压，在芯片断电时输出与总线上其他芯片电压相等的控制电压。