renal

摘要： It has been reported that up to 90%of organ transplant recipients have suboptimal blood pressure control.Uncontrolled hypertension is a well-known culprit of cardiovascular and overall morbidity and mortality.In addition,rigorous control of hypertension after organ transplantation is a crucial factor in prolonging graft survival.Nevertheless,hypertension after organ transplantation encompasses a broader range of causes than those identified in non-organ transplant patients.Hence,specific management awareness of those factors is mandated.An in-depth understanding of hypertension after organ transplantation remains a debatable issue that necessitates further clarification.This article provides a comprehensive review of the prevalence,risk factors,etiology,complications,prevention,and management of hypertension after organ transplantation.

摘要： Dear editor,Myelolipomas are uncommon,benign tumors of the adrenal gland that can occasionally attain a large size.These tumors,very rarely,can occur along with renal cell carcinoma[1].We describe the first case of a giant right sided adrenal myelolipoma co-existent with a contralateral renal cell carcinoma,both of which could be operated laparoscopically in the same sitting.

摘要： Small renal mass(SRM)incidence has been increasing over last decades due to the widespread access to diagnostic tools and is now accounting for 48%e66%of all renal cell carcinoma(RCC)diagnoses[1].The optimal management of SRM is still debated since approximately 25%of T1a is benign lesions.The role of active surveillance(AS)and the problem of SRM overtreatment are widely described in the current literature.However,RCC mortality has remained stable over the last 2 decades.The major strength of AS is the“tetrafecta”concept as it brings renal function preservation,safe oncological outcomes,and no surgical complications,and it maintains quality of life.AS is nowadays considered as a safe strategy for many SRMs.

摘要： It hasbeen agreat honortohave the opportunityto serve as guest editors for this issue of the Asian Journal of Urology(AJU)on renal cancer.Renal cell carcinoma(RCC)represents about 3%of all adultmalignanciesand95%ofallrenalmassesanditisstill one of the most lethal urological cancers[1].In the last decades,diagnosis and management of Rcc have rapidly changed.As incidental diagnosis of small cancers has become more frequent due to the wideruse of imaging techniques,active surveillance and nephron-sparing surgical techniques mainly performed with minimally invasive approaches have become popular.

摘要： 目的 探讨R.E.N.A.L.,PADUA和C-index三种评分系统在肾部分切除术中的应用价值.方法 对本院2013年1月至2020年6月收治的134例行PN的单侧肾肿瘤患者临床资料进行回顾性分析,阅读134例单侧肾肿瘤患者术前影像学资料,应用R.E.N.AL.,PADUA和C-index三种评分系统对肾肿瘤解剖特征进行评分并分组,分析三个评分系统评分之间的相关性,分析三种评分系统不同组别间热缺血时间、估计出血量、手术时间、手术前后血肌酐升高值及住院天数的相关性.结果 61例和73例患者分别接受了开放式和腹腔镜下肾部分切除术.三种评分系统两两相关,R.E.N.A.L.和PADUA之间的相关性最强(相关系数:0.749,P<0.001),其次是C-index和PADUA(相关系数:-0.266,P=0.002),最后是C-index和R.E.N.A.L.(相关系数:-0.191,P=0.027).R.E.N.A.L.、PADUA评分分组与热缺血时间、估计出血量存在正相关,而与手术时间、肌酐升高值及住院时间无明显相关.C-index评分分组不仅与热缺血时间和估计出血量相关,还与手术时间存在显著正相关,且相关系数均高于其他两个评分系统,C-index评分分组与肌酐升高值及住院时间无明显相关.结论 三个评分系统均可对手术复杂程度及相关风险进行评估,C-index评分系统优于R.E.N.A.L.和PADUA.

摘要： Tubulointerstitial fibrosis(TIF)is one of the main pathological features of various progressive renal damages and chronic kidney diseases.Mesenchymal stromal cells(MSCs)have been verified with significant improvement i the therapy of fibrosis diseases,but the mechanism is still unclear.We attempted to explore the new mechanism and therapeutic target of MSCs against renal fibrosis based on renal proteomics.TIF model was induced by adenine gavage.Bone marrow derived MSCs was injected by tail vein after modeling.

摘要： Persistent activation of Y esassociated protein(YAP)is profoundly implicated in facilitating transformation of myofibroblasts.However,its roles in the pathogenesis of renal fibrosis remain largely unexplored.In the present study,an upregulation of YAP was detected by qRT-PCR,Western blotting,and immunohistochemistry both in the kidney tissues of folic acid(F A)-induced chronic kidney disease(CKD)mice,and in SV40MES 13 cells stimulated with TGF-β1.The microRNAs predicted to target YAP were explored by transfection of miR-590-5p mimics or inhibitors and analyzed by luciferase reporter assay.The reporter indicated that miR 590-5p directly targeted the YAP 3-untranslated region.

摘要： Medical University,Shenyang 110122,China.The mechanical microenvironment of cells is recently reported to associate with the progression of renal fibrosis.However,the mechanism has not been fully elucidated.In the present study,based on the precision measurement of atom force microscope(AFM),hydrogel substrates of various stiffness were prepared to simulate the hardness of extracellular matrix(ECM)in normal and fibrotic kidney tissue.Renal mesangial cells were then cultured on the hydrogel matrix with different hardness.

摘要： Introduction: The risk of rupture of true renal artery aneurysms is low but when they are bigger than 2 - 2.5 cm it increases significantly, making treatment essential. The need to use alternatives to conventional techniques in order to avoid predictable complications as coil migration is mandatory. Discussion: Routinely-used techniques in interventional neuroradiology such as flow diverters or those assisted with an occlusion balloon or stent have are suitable alternatives for complex aneurysms. Conclusion: Interventional neuroradiology devices such as the Cascade Net stent (Perflow Medical and Grupo Logsa) and Solitaire AB stent retriever (Medtronic) are valid and safe options. We describe the technique of such devices.

摘要： BACKGROUND Pheochromocytomas with inferior vena cava(IVC)or renal vein tumor thrombus are rare.Surgical management is the first choice.CASE SUMMARY We presented a 42-year-old man with adrenal pheochromocytoma and delayed tumor thrombus detection in the renal vein at the entrance of the IVC three months after adrenalectomy.We performed laparoscopic adrenalectomy during the first surgery and robot-assisted laparoscopic nephrectomy and resection of tumor thrombus during the second surgery.CONCLUSION We report the surgical management of a patient with adrenal pheochromocytoma with tumor thrombus at the entrance of the IVC.Robot-assisted laparoscopic surgery is safe and efficient.