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reactive

reactive的相关文献在1992年到2022年内共计253篇,主要集中在肿瘤学、内科学、化学 等领域,其中期刊论文250篇、专利文献3篇;相关期刊128种,包括中国药理学通报、中国心血管病研究、中国科学等; reactive的相关文献由860位作者贡献,包括Andrey Kratnov、Ashwani Kumar、Eduardo Martínez-Naves等。

reactive—发文量

期刊论文>

论文:250 占比:98.81%

专利文献>

论文:3 占比:1.19%

总计:253篇

reactive—发文趋势图

reactive

-研究学者

  • Andrey Kratnov
  • Ashwani Kumar
  • Eduardo Martínez-Naves
  • Eko Supriyanto
  • Elena Timganova
  • Francisco Javier Cubero
  • Gerardo Cifuentes
  • Jing Wang
  • José Hernández
  • Leonard J Nelson
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  • 专利文献

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    • Meng-Yao Wang; Jing-Wen Zhao; Chang-Qing Zheng; Li-Xuan Sang
    • 摘要: Recently,biological drugs have played a leading role in the treatment of inflammatory bowel disease,and therapeutic drug monitoring(TDM)may be useful in maximizing their effectiveness.TDM involves the measurement of serum drug and anti-drug antibodies concentrations as the basis for dosage adjustments or drug conversions to achieve a higher response rate.We believe that concentration thresholds should be individualized based on patients’disease severity,extent and phenotype,and therapeutic purposes should also be considered,with higher cut-offs mainly needed for endoscopic and fistula healing than for symptomatic remission.Proactive and reactive TDM can help optimize treatment,especially in patients receiving anti-tumour necrosis factor,and guide dose adjustment or drug conversion with lower cost.TDM is a promising approach to achieve precision medicine and targeted medicine in the future.
    • Farah Albader; Petra Anna Golovics; Lorant Gonczi; Talat Bessissow; Waqqas Afif; Peter Laszlo Lakatos
    • 摘要: Inflammatory bowel disease(IBD)is a chronic condition that significantly affects the quality of life of its patients.Biologic drugs have been the mainstay treatment in the management of IBD patients but despite their significant contribution,there remains a proportion of patients that do not respond or lose response to treatment.Therapeutic drug monitoring(TDM)involves measuring levels of serum drug concentrations and anti-drug antibodies.TDM of biologic drugs initially emerged to understand treatment failure in other immune mediated inflammatory diseases.This was then introduced in IBD to rationalize primary non-response or secondary loss of response,given that low serum drug concentrations or the formation of anti-drug antibodies are variably associated with treatment failure.The aim of this narrative review is to provide an overview regarding the current use of TDM in clinical practice and to present the evidence available regarding its use in both proactive and reactive clinical settings in preventing and managing treatment failure.This review also presents the existing evidence regarding the association of various clinical outcomes with specific thresholds of drug concentrations,in everyday practice.A narrative review of published articles and conference abstracts regarding the use of TDM in IBD management,through an electronic search using PubMed and ScienceDirect.TDM has proven to be superior and more cost effective in guiding management of patients with treatment failure compared to empiric dose escalation or change in treatment.Despite a trend towards an association between clinical outcomes and drug concentrations,proactive TDM based strategies have not been shown to achieve clear benefit in long-term outcomes.In the clinical setting,TDM has proven to be useful in managing IBD patients,and its use in the reactive setting,as an additional tool to help manage patients with treatment failure,is being promoted as newer guidelines and consensus groups implement TDM as part of the management plan.
    • Sun Weiliang; Guo Jing; Zhang Yuting; Gao Yanxiang
    • 摘要: A variety of NADPH oxidase(Nox)isoforms including Noxs 1,2,4 and 5 catalyze the formation of reactive oxygen species(ROS)in the vascular wall.The Noxl isoform complex in smooth muscle cells has received greater attention in the progression of atherogenesis in animal models.Thus,we explored the effect of traditional Chinese herbal medicine monomer tanshinone IIA on microcalcifications,and investigated the underlying molecular mechanism of ROS.The 8-week old maleapolipoprotein E-deficient(ApoE^(-/-))mice and C57BL/6 mice were divided into three groups:Control group(C57BL/6 mice),Model group(ApoE^(-/-) mice).
    • Reem Ghazali; Kosha J Mehta; SW Annie Bligh; Ihab Tewfik; Dahn Clemens; Vinood B Patel
    • 摘要: BACKGROUND Non-alcoholic fatty liver disease(NAFLD) is a common cause of liver disease worldwide and is a growing epidemic. A high ratio of omega-6 fatty acids to omega-3 fatty acids in the diet has been implicated in the development of NAFLD. However, the inflicted cellular pathology remains unknown. A high ratio may promote lipogenic pathways and contribute to reactive oxygen species(ROS)-mediated damage, perhaps leading to mitochondrial dysfunction.Therefore, these parameters were investigated to understand their contribution to NAFLD development.AIM To examine the effect of increasing ratios of omega-6:3 fatty acids on mitochondrial function and lipid metabolism mediators.METHODS Hep G2-derived VL-17 A cells were treated with normal(1:1, 4:1) and high(15:1,25:1) ratios of omega-6: omega-3 fatty acids [arachidonic acid(AA):docosahexaenoic acid(DHA)] at various time points. Mitochondrial activity and function were examined via MTT assay and Seahorse XF24 analyzer, respectively.Triglyceride accumulation was determined by using Enzy Chrom? and levels of ROS were measured by fluorescence intensity. Protein expression of the mediators of lipogenic, lipolytic and endocannabinoid pathways was assessed by Western blotting.RESULTS High AA:DHA ratio decreased mitochondrial activity(P < 0.01;up to 80%) and promoted intracellular triglyceride accumulation(P < 0.05;40%-70%).Mechanistically, it altered the mediators of lipid metabolism;increased the expression of stearoyl-Co A desaturase(P < 0.05;22%-35%), decreased the expression of peroxisome proliferator-activated receptor-alpha(P < 0.05;30%-40%) and increased the expression of cannabinoid receptor 1(P < 0.05;31%).Furthermore, the high ratio increased ROS production(P < 0.01;74%-115%) and reduced mitochondrial respiratory functions such as basal and maximal respiration, ATP production, spare respiratory capacity and proton leak(P < 0.01;35%-68%).CONCLUSION High AA:DHA ratio induced triglyceride accumulation, increased oxidative stress and disrupted mitochondrial functions. Stimulation of lipogenic and steroidal transcription factors may partly mediate these effects and contribute to NAFLD development.
    • Huey K Tan; Euan Yates; Kristen Lilly; Ashwin D Dhanda
    • 摘要: Alcohol consumption is one of the leading causes of the global burden of disease and results in high healthcare and economic costs.Heavy alcohol misuse leads to alcohol-related liver disease,which is responsible for a significant proportion of alcohol-attributable deaths globally.Other than reducing alcohol consumption,there are currently no effective treatments for alcohol-related liver disease.Oxidative stress refers to an imbalance in the production and elimination of reactive oxygen species and antioxidants.It plays important roles in several aspects of alcohol-related liver disease pathogenesis.Here,we review how chronic alcohol use results in oxidative stress through increased metabolism via the cytochrome P4502E1 system producing reactive oxygen species,acetaldehyde and protein and DNA adducts.These trigger inflammatory signaling pathways within the liver leading to expression of pro-inflammatory mediators causing hepatocyte apoptosis and necrosis.Reactive oxygen species exposure also results in mitochondrial stress within hepatocytes causing structural and functional dysregulation of mitochondria and upregulating apoptotic signaling.There is also evidence that oxidative stress as well as the direct effect of alcohol influences epigenetic regulation.Increased global histone methylation and acetylation and specific histone acetylation inhibits antioxidant responses and promotes expression of key pro-inflammatory genes.This review highlights aspects of the role of oxidative stress in disease pathogenesis that warrant further study including mitochondrial stress and epigenetic regulation.Improved understanding of these processes may identify novel targets for therapy.
    • Hao Wu; Ruikai Ye; Xingxing Dong; Kunjian Yu; Zhengwei Chang
    • 摘要: In order to improve the reliability of fault identification of the double-circuit transmission lines on the same tower, a new algorithm for fast protection of double-circuit transmission lines on the same tower based on the reactive powers of traveling wave is proposed. With the implementation of S-transform, the initial traveling wave reactive powers are calculated and the change characteristics of reactive power under different fault conditions are studied. The protection criterion is constructed by analyzing the ratio of the reactive powers of the same end on double-circuit transmission lines and the ratio of the reactive powers at both ends on the same line. According to the ratio of reactive power on the same side of the line and both ends of the same line, it is possible to identify whether the faults of the double-circuit line of the same tower occurred in or out of the protection zone. A large number of simulation results show that the protection performance is sensitive and reliable, and quick to respond. The criterion is simple and is basically not affected by fault initial angles, fault types, and transitional resistances.
    • Ashraya Upadhyaya; Guillermo Rincoacute; n
    • 摘要: The sanitary and environmental challenges posed by an ever growing economically and geographically diverse human population include the need for sustainable, inexpensive, scalable, and decentralized water treatment technologies that can supplement or replace conventional treatment methods. These challenges can be met by semiconductor photocatalysis, especially if the process is driven by visible light energy. Visible-light active (VLA) photocatalysis, as opposed to traditional energy-intensive and chemically driven disinfection methods such as ozonation, UV irradiation and chlorination, has the potential for achieving high disinfection efficiency with low energy consumption and no harmful by-products. This technology generates in-situ reactive oxygen species (ROS) such as H2O2, and?, without the need for chemicals addition. In turn, ROS are capable of penetrating cell walls and membranes of microorganisms, effectively inactivating them. Although multiple types of VLA photocatalysts have been used experimentally for disinfection of water, noble-metal-based photocatalysts have gained the most interest due to their surface plasma resonance (SPR) effect, which acts synergistically to increase the disinfection potential of the photocatalytic process. This paper is a review of the different types of noble-metal-based VLA photocatalysts used for water disinfection in different experimental settings, their synthesis procedures and disinfection mechanisms. It also discusses innovative approaches to overcome a major hurdle in photocatalysis, that is, the rapid recombination of the electron and hole pair, by including specific dopants into the structure of the photocatalyst.
    • Hiba A. Awooda
    • 摘要: Stroke is a devastating disease with a complex pathophysiology;it ranks second to ischemic heart disease as a cause of death and long-term disability. Tissue damage results from diverse mechanisms with central involvement of free radicals’ overproduction that results in oxidative stress and hence contributes to brain damage. Free radicals [Reactive oxygen species/Reactive nitrogen species] play central a role in the diverse normal physiological processes and as defense mechanisms against harmful substances. When the rate of their production exceeds the anti-oxidant capacity of the body, oxidative stress occurs. Oxidative stress is implicated in the pathogenesis of various diseases including hypertension, atherosclerosis, diabetes mellitus and cancer;they mediate damage to cell structures, lipid peroxidation, protein denaturation, nucleic acid and DNA damage.
    • Akanksha Verma; Ramovatar Meena; Anurag Maurya; Usha Singh Gaharwar; Paulraj Rajamani
    • 摘要: Sugarcane burning during harvest and non-harvest season emits various pollutants like volatile organic compounds (VOCs), alkanes, and PAHs (Polyaromatic hydrocarbons) in the surrounding environment. Among these pollutants, PAHs are of uttermost concern due to their high level of toxicity. Burning of sugarcane bagase in sugar mill results in the production of fly ash. Fly ash is produced as a result of sugarcane bagasse burning in sugar mills. In present study, fly ash that comes out from the sugar mill chimney was collected from Western Uttar Pradesh, India and used for further analysis. High temperature and incomplete combustion inside chimney lead to the formation of PAHs. Extraction of PAHs present in fly ash samples was done by ultrasonication method and was identified with GC-FID (gas chromatography-flame ionization detector). Results exhibit the presence of eight PAHs in fly ash samples where the Benzo(a)pyrene and Naphthalene were found to be in high concentration. Furthermore, we have evaluated toxic effects of fly ash and Polyaromatic hydrocarbons (Standard of BaP & Nap) through different methods i.e. MTT, ROS and comet assay. Significant reduction (p < 0.001) in cell viability was noted in cells treated with fly ash as compared to control. Fly ash samples were also found to induce significant oxidative stress in HeLa cells, which ultimately causes DNA damage. Therefore, it may be concluded that the fly ash samples are toxic to the environment due to the presence of PAHs. Hence, the present study plays an important role in determining the harmful effects of PAHs and their source of occurrence.
    • Junya Ishikawa; Taro Morisaki
    • 摘要: Mutations in the Sfpi1 gene are essential for the development of radia-tion-induced acute myeloid leukemia. In this study, we investigated long-term interaction among immature hematopoietic cell number, intra-cellular reactive oxygen species contents, and oxidative DNA damage fre-quency after irradiation. Lin-/Sca-1+ cells were isolated from C3H/HeN mice on days 1 - 400 after 0 - 3 Gy total body irradiation. On days 1 - 7, the number of surviving cells decreased and reached a minimum;however, the number of cells gradually recovered until day 200. Intracellular reactive oxygen species contents significantly increased from day 1 to day 30. In addition, the frequency of oxidative DNA damage tended to increase from day 1 and day 30, and that at day 30 was significantly increased in the 3 Gy group compared with that in the control group. In contrast, decreased cell number, increased intracellular reactive oxygen species content, and decreased oxidative DNA damage frequency were observed on day 400. These results suggested that oxidative DNA damage was involved in intracellular reactive oxygen species generation induced by cell proliferation to compensate for cell death after irradiation.
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