Press

摘要： 最近与肿瘤发展相关的病毒基因突变已成为研究的主要焦点,慢性乙型肝炎病毒感染(HBV)仍然是肝细胞癌(HCC)最常见的危险因素.preS/S突变体被认为是HCC的"前体病变",可诱导蛋白相关反应和内质网应激依赖及不依赖途径,它与HBx蛋白在HBV感染相关肝癌发生中起关键作用.还有HBV入胞转运体、DNA转录及miRNA也证明与肝癌进展相关.除了HBV和AFB1暴露外,宿主因素可能在HCC的发生中也发挥作用.然而,HBV感染促进HCC发展的分子机制尚不完全清楚.本文探讨了HBV相关性肝癌发生的突变基因,为肝癌的发生、发展及预测提供了思路.

摘要： Technological advancement has contributed immensely to human life and society.Technologies like industrial robots,artificial intelligence,and machine learning are advancing at a rapid pace.While the evolution of Artificial Intelligence has contributed significantly to the development of personal assistants,automated drones,smart home devices,etc.,it has also raised questions about the much-anticipated point in the future where machines may develop intelligence that may be equal to or greater than humans,a term that is popularly known as Technological Singularity.Although technological singularity promises great benefits,past research works on Artificial Intelligence(AI)systems going rogue highlight the downside of Technological Singularity and assert that it may lead to catastrophic effects.Thus,there is a need to identify factors that contribute to technological advancement and may ultimately lead to Technological Singularity in the future.In this paper,we identify factors such as Number of scientific publications in Artificial Intelligence,Number of scientific publications in Machine Learning,Dynamic RAM(Random Access Memory)Price,Number of Transistors,and Speed of Computers’Processors,and analyze their effects on Technological Singularity using Regression methods(Multiple Linear Regression and Simple Linear Regression).The predictive ability of the models has been validated using PRESS and k-fold cross-validation.Our study shows that academic advancement in AI and ML and Dynamic RAM prices contribute significantly to Technological Singularity.Investigating the factors would help researchers and industry experts comprehend what leads to Technological Singularity and,if needed,how to prevent undesirable outcomes.

摘要： 近几年,数字印刷的行业巨头相继推出喷墨印刷设备,把喷墨技术推向了新高度。在高端精密制造、精细化学、光学技术上有一技之长的富士胶片集团早在2004年便开始构思喷墨型数字印刷理念,到2018年末发布了第三代机型——Jet Press 750S B2幅面单张纸喷墨数字印刷机。

摘要： To develop the green polymeric membrane electrolyte,-Polycaprolactone(PCL)was used as a host and the Ionic liquid(IL)(1-Ethyl-3-methylimidazolium tosylate)as a dopant.The IL is a source of mobile charges in the polymer electrolyte system.The composite membrane has been prepared by Hot Press method and then we characterised this membrane for ionic transportation.Formation of nanocomposite system has been ascertained from their XRD pattern.Interaction phenomenon was studied by ATR based FTIR and Laser Raman spectroscopic technique.Variation of conductivity with composition and temperature was studied with the aid of impedance spectroscopy data.

摘要： The study aimed to analyze the reporting and methodological quality of systematic reviews(SRs)/meta-analyses(MAs)of animal models to provide references for later studies and avoid the waste of medical resources.EMBASE and MEDLINE databases were searched from inception to November 2017,with no language restriction.Two reviewers selected inclusion dependently and extracted the basic characteristics.Review Manager 5.3,stata 12.0,and SPSS 21 software were used to conduct analyses.A total of 46 SRs/MAs were included.The results showed that the English databases with high retrieval frequency are PubMed/MEDLINE,EMBASE,and Web of Science.67.31%(31/46)of the articles reported the search strategy in the full text or the appendix.65.22%(30/46)reported the literature screening flow diagram,and only 19.57%(9/46)reported the number of works of literature retrieved in each database.60.87%(28/46)illustrated supplement retrieval.Through 2 subgroup analyses,it was found that there were no significant differences in the quality of reports of PRISMA items.But referring to the methodological quality or reporting of PRESS items,SCI was better than that of non-SCI,while there seemed a source of funding to have no significant impact on the methodological quality or the items of PRESS.The results of PRESS,AMSTAR 2,and PRISMA were correlated,and the correlation between PRISMA and AMSTAR 2 was strong.These results demonstrated that search strategies of animal model SRs/MAs are still not enough comprehensive,report specification and methodological quality still need to be ameliorated.To show users the scientificity and rigor of the study,future research should focus on these various guidelines like PRESS,PRISMA,and AMSTAR 2 checklists that have been issued,it can help to increase the value of research and improve the utilization of medical resources.

摘要： Chronic hepatitis B is a global health problem. The clinical outcomes of chronic hepatitis B infection include asymptomatic carrier state, chronic hepatitis(CH), liver cirrhosis(LC), and hepatocellular carcinoma(HCC). Because of the spontaneous error rate inherent to viral reverse transcriptase, the hepatitis B virus(HBV) genome evolves during the course of infection under the antiviral pressure of host immunity. The clinical significance of pre-S/S variants has become increasingly recognized in patients with chronic HBV infection. Pre-S/S variants are often identified in hepatitis B carriers with CH, LC, and HCC, which suggests that these naturally occurring pre-S/S variants may contribute to the development of progressive liver damage and hepatocarcinogenesis. This paper reviews the function of the pre-S/S region along with recent findings related to the role of pre-S/S variants in liver diseases. According to the mutation type, five pre-S/S variants have been identified: pre-S deletion, pre-S point mutation, pre-S1 splice variant, C-terminus S point mutation, and pre-S/S nonsense mutation. Their associations with HBV genotype and the possible pathogenesis of pre-S/S variants are discussed. Different pre-S/S variants cause liver diseases through different mechanisms. Most cause the intracellular retention of HBV envelope proteins and induction of endoplasmic reticulum stress, which results in liver diseases. Pre-S/S variants should be routinely determined in HBV carriers to help identify individuals who may be at a high risk of less favorable liver disease progression. Additional investigations are required to explore the molecular mechanisms of the pre-S/S variants involved in the pathogenesis of each stage of liver disease.

摘要： 近日,全球领先的商务解决方案增值服务商——柯尼卡美能达隆重推出生产型标签数字印刷系统bizhub PRESS C71cf。新品以生产型数字印刷设备为引擎,融以柯尼卡美能达多年积累的先锋科技,智能高效,品质卓越,可平衡客户在质量和成本方面的双重需求。适应全球日益增长的数字化标签市场,助力客户把握市场潮流,创造更多商业新价值。近年来,全球标签市场正在日益扩大,未来有望进一步稳定发展。这其中,

摘要： 目的： 探讨在原发性开角型青光眼患者治疗中应用 EX-PRESS 青光眼引流钉植入术与传统小梁切除术的临床效果。 方法：选取我院2013年2月～2014年2月收治的60例原发性开角型青光眼患者为研究对象， 随机分成A组与B组， A组应用EX-PRESS青光眼引流钉植入术治疗，B 组应用传统小梁切除术治疗，比较治疗效果。结果：A 组治疗有效率为 93.33%，与 B 组治疗有效率 96.67%。结论：EX-PRESS 青光眼引流钉植入术与传统小梁切除术对原发性开角型青光眼的治疗效果都较好，医生可以根据患者具体情况选择合适的治疗方法。

摘要： 机会人人都有处处都有,但并非所有人都能把握得住。我们经过长期观察,将绝大多数人分为两种类型,第一种是能发现机遇的人,第二种是不能发现机遇的。而前者从结果上考量又可分为能把握机遇成功的人,以及即使发现了机遇,也有不能把握住机遇、无法成功的人。当下市场瞬息万变,最近几年的环境趋势对印刷行业愈发不利,如北京已经出台了新的环境保护法,当然,

摘要： AIM To assess the functional and clinical results of repair of chronic tears of pectoralis major using corkscrew and sliding suture technique. METHODS In this retrospective study, we reviewed the results of pectoralis major repair in 11 chronic cases(> 6 wk) done between September 2011 and December 2014 at our institute. In all cases repair was done by same surgeon using corkscrew suture anchors and box suture sliding technique. At 6 mo, after surgery magnetic resonance imaging was done to see the integrity of the repair. Functional evaluation was done using Penn and ASES scores. Pre and postoperative Isokinetic strength was measured.RESULTS Average follow-up was 48.27 ± 21.0 mo. The Wilcoxon signed rank test was used to evaluate the outcome scores. The average ASES score increased from an average of 54.63 ± 13.0 preoperatively to 95.09 ± 2.60 after surgery at their last follow-up. The average Penn score also increased from 5.72 ± 0.78, 2.81 ± 1.32 and 45.81 ± 1.72 to 9.36 ± 0.80, 8.27 ± 0.90 and 59 ± 1.34 for pain, satisfaction and function respectively. Follow up magnetic resonance imaging(MRI)(at 6 mo) showed continuity and the bulk of pectoralis major muscle in all cases. Average isokinetic strength deficiency in horizontal adduction at 60° was 13.63% ± 6.93% and at 120° was 10.18% ± 4.93% and in flexion at 60° was 10.72% ± 5.08% and at 120° was 6.63% + 3.74%. Results showed that both ASES and Penn score improved significantly(2 tailed P value = 0.0036).CONCLUSION We could conclude from this series that pectoralis major repair even in chronic cases using 5.5 mm corkscrew anchors give excellent functional and cosmetic results. In chronic cases the repairable length of the tendon is not available and sliding suture technique allows for fixation of worn out tendomuscular junction to bone without letting cutting through the muscle.

摘要： 本发明提供一种冲压成型方法，是利用凹模和凸模挤压成型出冲压成型制品的冲压成型方法，该冲压成型制品至少具有顶板部及通过连接部与该顶板部相连的纵壁部，且在俯视时该纵壁部的整体或者一部分向冲压成型制品的外侧弯曲成凸出状。在该冲压成型方法中，使板料的前端部一直与凹模的纵壁成型部接触。而且，凹模的纵壁成型部以除了该接触以外不进行对板料的前端部的限制的状态，来将冲压成型制品的纵壁部成型。

摘要： 本实用新型公开了一种press反应釜，包括主釜体，所述主釜体的顶部固定连接有驱动电机，所述驱动电机的输出端固定连接有传动杆，所述传动杆远离驱动电机的一端贯穿主釜体的顶部并向内延伸，所述传动杆靠近驱动电机的一端转动套接有机械密封圈，所述机械密封圈的边缘和主釜体的内壁相抵，所述传动杆的下端固定连接有多个搅拌棒，所述传动杆上转动套接有支撑杆，所述支撑杆位于机械密封圈和搅拌棒之间，所述支撑杆远离传动杆的一端和主釜体的内壁固定连接，所述支撑杆内设有空腔，所述空腔内转动连接有蜗杆。本实用新型通过搅拌棒和螺旋搅拌带的设置，使装置可以使反应釜内的物料充分混合，从而保证产品的质量。