Paris

摘要： Background: Lewy body disease (LBD) is a neurodegenerative affection responsible for impaired quality of life. The objective was to share the data experience of 14 years concerning the functional, neuropsychological and behaviors effects on geriatrics patients. Methodology: Descriptive retrospective study over 14 years (2005 to 2019) in the geriatrics department of Pitié Salpétrière Hospital, using the instrumentals activity of daily living (IADL) sheets and the neuropsychological inventory (NPI) assessed at the moment diagnosis according to the diagnostic criteria of 2017 and 1996. Results: A total of 70 patients including 55 exploitable files had been listed with a mean age 82.6 years [70 - 91], a sex ratio 1.2 in men favor, a mean socio-cultural level 5.2 [1 - 7], a mean Cumulating Illness Scale (CIRS52) = 10 [1 - 22]. The mean IADL and NPI were respectively 9.3 [3 - 11] and 25.1 [0 - 79]. We found an early global impairment of IADL activities frequent in transport (65%), medication management (49%), and displacement (42%) for basic activities without significant statistical difference between the age and sex groups but statistically significant early involvement with polypathology after adjustment for displacement (45%) and transport (65%). The IADL impairment is significant as soon as the MMS-BREF decreases. Hoen Yahr (HY) scale increase could influences shopping (22%), displacement (27%) after adjustment. NPI disorders frequently found were apathy-depression (31.8% - 25%), anxiety (28%), irritability (25.6%) and sleep disturbance (22.9%) after 80 years old independently of gender and poly-pathology. Also, the best mental status was associated of less disturbance of NPI items. Conclusion: Polypathology, motor disorders and cognitive decline seem to influence IADL while with advanced age, cognitive decline appears to be worsened early in LBD.

摘要： Texworld Evolution Paris The February 2022 edition marked the return of the international sourcing platform Texworld Evolution Paris in its classic configuration.After two years,the professionals of the fashion industry were able to meet the international manufacturers selected by the Messe Frankfurt France team in the Hall 4 of the Paris-Le Bourget Exhibition Center.

摘要： Texworld Evolution Paris opened its doors from 4 to 6 July 2022 at the Paris-Le Bourget Exhibition Center.Apparel Sourcing Paris,Avantex Paris,Leatherworld Paris and Texworld Paris trade fairs concentrated for 3 days the essential global offer for fashion brands,from ready-to-wear to luxury.

摘要： A few days ago,Coperni Spring/Summer 2023 series show at Paris Fashion Week made the whole fashion industry feel shocked and fresh.What’s happened?At the end of the big show,supermodel Bella Hadid appeared in nude underwear.Then,just like a performance art show,two staff members took airbrushes and sprayed directly on her.After a few minutes,the liquid covering the model gradually dried and turned into a piece of white matte fabric.Wonderful technology dominates this magical transformation.After some simple cutting,a sexy and stunning fashion dress is presented in front of audience.From liquid to fabric,from plane to three-dimensional,technology shortened the creation time of the dress to a few minutes,giving people a shocking design that challenges their cognition.

摘要： RNA作为遗传信息的传递者,具有调控基因表达,翻译蛋白质等功能.然而,越来越多的研究表明,RNA相互作用对RNA行使生物学功能起到重要作用.目前有许多基于高通量测序的方法应用于RNA相互作用研究,然而不同的实验方法之间可能存在偏好性,同时RNA相互作用在细胞内是动态变化的,因此不同方法得到的RNA相互作用结果可能存在差异.本文主要对近年开发的PARIS,RIC-seq,hiCLIP等研究转录组范围RNA相互作用的高通量测序技术的原理、研究方法及优缺点进行讨论总结,并进一步对今后的RNA互作研究进行了展望.

摘要： 巴黎充满了学习新东西和收获新体验的机会。在巴黎,你会遇见新的自己。Paris is the city of love.It's no secret that it is one city that everyone has heard about.Its fame precedes(先于)it,but some might ask,what exactly is so great about Paris?The city is full of opportunities to learn something new and have new experiences.

摘要： cqvip:巴黎充满了学习新东西和收获新体验的机会。在巴黎,你会遇见新的自己。Paris is the city of love.It's no secret that it is one city that everyone has heard about.Its fame precedes(先于)it,but some might ask,what exactly is so great about Paris?The city is full of opportunities to learn something new and have new experiences.

摘要： 当你徜徉于巴黎这座欧洲大陆上最令人心驰神往的曼妙花都时、每每都会惊叹于她的无限风情、深厚文韵以及那最为动人的时尚之光,可曾想过这座华美都市曾于十四世纪,在那场令整个欧洲为之陷落的瘟疫中历经挣扎,而后却在灾难下涅槃新生,映照出更为旖旎的绝代光色,并保持如斯姿态最终成为当下世界最能代表时尚的奇迹城市。

摘要： Paris polyphylla var. yunnanensis (Franch.), one of the best-known medicinal plants in China, has a dehiscent anther which physiologically work in pollination, however, the dehiscent anther always closes in response to darkness every day, and watering or raining every time. To explore this frequently closing and its unkown physiology, next-generation sequencing was performed, and the transcriptome was de novo assembled. RNA-sequencing was carried out in 15 samples including seven openning samples, four closed samples owing to darkness or watering, and tissue samples (leaf, petal, calyx, and stigma) were used for control. We obtained 72.75 GB data, assembled into 79,815 unigenes. Differentially expressed unigenes (DEGs) between opened and closed anther samples were 6231 and the DEGs between anther and control samples were 2831. Comparation between the two DEGs by KEGG enrichment showed that “plant hormone signal transduction” pathway is the most significant pathway for DEGs from closing anther vs. opening anther, and expression model of DEGs in the pathway might elicit change in germination and seed dormancy. Further examination of the action of the signal pathway on physiology showed “chromatin binding” function was prominent in “DNA binding” function of annotated DEGs between opened and closed anthers, of the 215 “chromatin binding” unigenes, 120 were involved in epigenetic silencing, and 50 of the epigenetic unigenes were directly related to germination or seed dormancy, strongly correlating anther closing to epigenetic modification and seed dormancy. These results were verified that at least three auxins involved in seed dormancy showed same expression patterns occurred in abnormal closing anther and seed embryo in Paris polyphylla var. yunnanensis. In conclusion, the information from transcriptome point out that frequent abnormal closing of dehiscent anthers possibly transfer the impact on seed dormancy, and epigenetic modification happened in closing may be the cause.

摘要： 应用断口定量反推疲劳寿命的理论基础,通过对裂纹长度与疲劳条带间距的测量,利用Paris公式,分别运用自然对数法和常用对数法对TA15钛合金进行了寿命反推,并对结果进行了比较,结果表明,在相同的条件下,应用常用对数法计算的疲劳扩展寿命与应用自然对数法计算的扩展寿命十分接近.

摘要： 应用断口定量反推疲劳寿命的理论基础,通过对裂纹长度与疲劳条带间距的测量,利用Paris公式,分别运用自然对数法和常用对数法对TA15钛合金进行了寿命反推,并对结果进行了比较,结果表明,在相同的条件下,应用常用对数法计算的疲劳扩展寿命与应用自然对数法计算的扩展寿命十分接近.

摘要： 应用断口定量反推疲劳寿命的理论基础,通过对裂纹长度与疲劳条带间距的测量,利用Paris公式,分别运用自然对数法和常用对数法对TA15钛合金进行了寿命反推,并对结果进行了比较,结果表明,在相同的条件下,应用常用对数法计算的疲劳扩展寿命与应用自然对数法计算的扩展寿命十分接近.

摘要： 应用断口定量反推疲劳寿命的理论基础,通过对裂纹长度与疲劳条带间距的测量,利用Paris公式,分别运用自然对数法和常用对数法对TA15钛合金进行了寿命反推,并对结果进行了比较,结果表明,在相同的条件下,应用常用对数法计算的疲劳扩展寿命与应用自然对数法计算的扩展寿命十分接近.

摘要： 揭示预防或治疗受试者的帕金森症的方法，其中，将有效量的药物给药至受试者，以造成PARIS的法尼基化以及脑内PGC‑1α表达的提升。这些方法部分地通过预防多巴胺神经元的丢失而减轻受试者帕金森症的效应。

摘要： 本发明属于材料疲劳裂纹扩展行为分析技术领域，提供了一种钛合金疲劳裂纹扩展速率曲线Paris区转折点的判定方法。该方法根据断口微观特征所表现出的裂纹扩展行为和断裂方式的变化，确定疲劳裂纹扩展机制发生转变时的裂纹扩展长度，通过求解该裂纹扩展长度所对应的应力强度因子幅和疲劳裂纹扩展速率，继而判定疲劳裂纹扩展速率曲线Paris区的转折点位置。本发明科学依据充分，精确度高，可满足设计使用者进行材料性能评价和损伤容限设计，利于现代化工程应用的需求。

摘要： 一种确定材料在不同应力比下的Paris参数C和m的方法，步骤为：一、在双对数坐标系中绘制材料在不少于四种不同应力比下的lgd

摘要： 本发明公开了一种基于Paris公式的疲劳寿命分析方法，获得材料的力学性能数据、疲劳SN曲线和应力比R＝0时的Paris材料常数和结构的应力强度因子曲线后计算裂纹长度影响因子，采用基于Paris的疲劳全寿命计算公式从初始裂纹长度到临界裂纹长度进行裂纹扩展寿命积分计算，得到并输出最终结构疲劳全寿命。本发明只需要基本常用的材料常数，避免了大量材料常数的试验测量，这对工程应用中进行结构全寿命分析是非常重要的。