Panel

摘要： BACKGROUND Gastric cancer is a common malignant tumor.Early detection and diagnosis are crucial for the prevention and treatment of gastric cancer.AIM To develop a blood index panel that may improve the diagnostic value for discriminating gastric cancer and gastric polyps.METHODS Thirteen tumor-related detection indices,38 clinical biochemical indices and 10 cytokine indices were examined in 139 gastric cancer patients and 40 gastric polyp patients to build the model.An additional 68 gastric cancer patients and 22 gastric polyp patients were enrolled for validation.After area under the curve evaluation and univariate and multivariate analyses.RESULTS Five tumor-related detection indices,12 clinical biochemical indices and 1 cytokine index showed significant differences between the gastric cancer and gastric polyp groups.Carbohydrate antigen(CA)724,phosphorus(P)and ischemia-modified albumin(IMA)were included in the blood index panel,and the area under the curve(AUC)of the index panel was 0.829(0.754,0.905).After validation,the AUC was 0.811(0.700,0.923).Compared to the conventional index CA724,the blood index panel showed significantly increased diagnostic value.CONCLUSION We developed an index model that included CA724,P and IMA to discriminate the gastric cancer and gastric polyp groups,which may be a potential diagnostic method for clinical practice.

摘要： 近几年来,我国高校本科生课堂教学质量备受重视,面向PBL&OBE的高校推进本科生课堂教学改革加速了课堂教学模式的创新发展,其中,高校文科生课堂因具有人文性、开放性和互动性特性,其改革模式更加受人青睐.然而,一些高校文科生课堂教学改革与人们的期待尚存在一定差距.panel教学模式因为更好地满足了PBL&OBE教学特征,以及其具有的和谐共振性、问题指向性、互动包容性、全员参与性、考察综合性特征而得到业界关注.panel教学模式由主题选择和边域确定、环境选择和邀约、panel介绍、发言者陈述、提问互动、问题引导和激励、学生评价和效果评估七个环节构成,每个环节均具有明确的任务和要求.通过若干高校和专业开展实践教学、科研互动交流,高校文科生课堂panel教学模式渐趋成为高校文科生课堂教学改革的选择.

摘要： Pancreatic ductal adenocarcinoma accounts for the primary type of pancreatic cancer(PC)with a 5-year survival rate of only about 10%in the United States.Early diagnosis will improve chances for curative treatment.To date,a broadly used serum marker for PC diagnosis is carbohydrate antigen 19-9,which is the only approved biomarker currently by the United States Food and Drug Administration.However,it has low specificity;therefore,development of novel biomarkers is urgently needed.Clinical trials are ongoing to evaluate candidate biomarkers for PC diagnosis,and the use of a multi-biomarker panel with current PC diagnostic biomarkers appears promising.

摘要： A high-level panel session has brought together the heads of the IEC,ISO and ITU-T to discuss the important role of standards in helping the world to achieve the United Nations Sustainable Development Goals(SDGs).Over 130 participants followed the online event,which took place as part of the World Standards Day celebrations.

摘要： 2020年7月22日,以“尽享畅快”为主题的创维电视夏季新品发布会在深圳召开。在这场发布会上,创维电视发布了高端OLED电视S81的升级款S81Pro及LIFErecorder 5G盒子,同时公布了8K内容生态新布局,以及Swaiot PANEL移动智慧屏和Swaiot CONNECTOR百变触点设备适配的新进展。

摘要： This study assesses the role of globalization-fueled regionalization policies on the financial allocation efficiency of four economic and monetary regions in Africa from 1980 to 2008.Banking and financial system efficiency proxies are used as dependent variables and seven bundled and unbundled globalization variables are employed as independent indicators.The bundling is achieved by principal component analysis,while the empirical evidence is based on interactive fixed effects regressions.The findings are as follows.First,financial allocation efficiency is more sensitive to financial openness compared to trade openness and most sensitive to globalization.The relationship between allocation efficiency and globalization-fueled regionalization policies is defined by:(i)a Kuznets or inverted U-shaped curve in the UEMOA and CEMAC zones(evidence of decreasing returns for allocation efficiency from globalization-fueled regionalization)and(ii)a U-shaped relationship overwhelmingly in the COMESA and scantily in the EAC(increasing returns to allocation efficiency due to globalization-fueled regionalization).These relationships are relevant to the specific globalization dynamics within regions.Economic and monetary regions are more prone to surplus liquidity than pure economic regions are.Policy implications and measures for reducing surplus liquidity are also discussed.

摘要： Please give a brief introduction to the current status of standards on panel display and Laser display in China and abroad.Zhao Ying:In fact,the industry chain of panel display is very Long,ranging from materials,the upper stream,display screen,modules and major components,the midstream,to terminal factories and all kinds of applications,the downstream.There are not only panel and planar displays but flexible displays and other display forms,as display technologies are evolving.

摘要： 在经济新常态、供给侧结构性改革背景下,零售业开启了转型升级之路,"新零售"概念的提出更是引发了零售业态的变革理念.探索以顾客为中心的零售新业态、推进零售业升级已成为当前商业发展必然趋势.本文以产业融合理论为视角剖析零售业融合发展的内在机理,构建Panel Date模型深层次分析制约零售业态转型的原因.结论显示,电子商务技术发展、互联网普及率、流通组织结构能够显著促进零售业态升级,而外资企业进驻加剧了零售业市场竞争,对整体盈利水平的提升呈现反向作用,但随时间的推移,影响趋于平稳.据此,进一步提出促进零售业态升级、提升顾客价值体验的具体建议.

摘要： Smart phones have become one of major electronic devices for human being. The easy and rapid exchange of information between man and machine is carried out by the touch screen panel (TSP) installed in the smart phones. Currently the smart phones are widely spread out while displays for automobiles are in the initial stage of developments. Since the automobile displays should fit the curved area of indoor space of the vehicle, the TSPs for automobiles need to be fabricated on the flexible and stretchable substrate film. In this study, we selected the thermo-plastic polyurethane film as the substrate film and examined the materials and process for fabrication of metal mesh type transparent conducting electrode films suitable for TSPs of automobile displays. The optimum UV resin system was established by the evaluation of various UV resin formulations in the UV imprinting process to make 3 × 3.5 μm trench patterns on the metal mesh type electrode film utilizing the embossed metal mask plate. The Ag paste has also been prepared by synthesis of Ag nanoparticles and formulation with the binder polymers. The inlay (filling) of Ag paste in the trench layer of transparent electrode film showed that the variation of electrical resistance was within 10% upon bending up to 100,000 times to radius of 3 mm.

摘要： The paper discusses the design, fabrication and the execution of the cladding supported by steel trusses and curtain wall of a sports club. The cladding and the curtain walls were subjected to a wind load of 1.2 Kpa considering basic wind speed of 25 m/s as per the project specifications. The first part of the paper deals with the cladding work of the canopy that consist of a 4 mm thick aluminium composite panels supported by steel trusses extended from the main structure. Two types of steel trusses were provided, the main truss connected to the space truss, whereas the intermediate truss connected to channels. Both trusses were spaced at 2.5 m centre to centre. These trusses were fabricated at factory and transported to the site for installation. The second part of the paper is related to the curtain wall design having Maximum Mullion spacing of 2 m, considered as worst scenario for the design calculations. The maximum Mullion height was 5.55 m, adopted in the calculations with bottom and top pinned connection. The Technal system was adopted for the design of mullions and transoms. Design was carried out using numerical modeling with CSI SAP2000 for cladding and its supporting structures. The bracket was realized and checked for the corresponding induced forces. All the structural systems were found safe according to different acceptance criterion.

摘要： 本文阐述了用AB-PLC与PANEL和CITECT监控软件实现电厂水预处理系统控制,并给出了系统软、硬件结构特点,实践证明该控制系统性能可靠易于管理,操作简单.

摘要： 本文阐述了用AB-PLC与PANEL和CITECT监控软件实现电厂水预处理系统控制,并给出了系统软、硬件结构特点,实践证明该控制系统性能可靠易于管理,操作简单.

摘要： 本文阐述了用AB-PLC与PANEL和CITECT监控软件实现电厂水预处理系统控制,并给出了系统软、硬件结构特点,实践证明该控制系统性能可靠易于管理,操作简单.

摘要： 本文阐述了用AB-PLC与PANEL和CITECT监控软件实现电厂水预处理系统控制,并给出了系统软、硬件结构特点,实践证明该控制系统性能可靠易于管理,操作简单.

摘要： 本文阐述了用AB-PLC与PANEL和CITECT监控软件实现电厂水预处理系统控制,并给出了系统软、硬件结构特点,实践证明该控制系统性能可靠易于管理,操作简单.

摘要： 本发明提供了一种地中海贫血Panel数据CNV分析系统，包括地贫Panel设计模块，用于针对每一个地贫CNV不同长度缺失断裂位点的探针覆盖距离单独设计；线性回归模型优化模块，用于评估每个样本中扩增子的深度中位数分布的情况，并筛选样本建模；地贫表型判断模块，通过设定CNV扩增子的阈值，统计CNV扩增子的数量及长度是否达到设定的阈值来判断该CNV表型；CNV结果过滤模块，用于自动比对确定CNV的起始位点和终止位点，自动过滤去除位于起始位点和终止位点之外的数据。本地中海贫血Panel数据CNV分析系统提高了地贫CNV识别准确度和灵敏度，减少了测序成本和背景噪音，增加捕获效率，识别准确率超过99.5％，种类覆盖国内报道的几乎所有CNV类型。

摘要： 本发明公开了一种用于基因检测Panel临床诊断指标算法开发的方法。属于属于细胞基因检测领域，具体步骤：提供基因位点信息表，对测序数据进行过滤；对测序数据进行模拟，将传递的数据作为虚拟基因检测Panel数据；采用既有的指标分析算法进行分析测序数据；采用既有的指标分析算法进行分析Panel数据；整合分析结果并进行模型训练；评估各种计算模型的性能，选择最优方案。本发明基于公共数据库全基因组和全外显子测序数据，通过基因检测Panel中各基因的位点信息从测序数据中摘取这些位点数据构建成虚拟的基因检测Panel数据，并在该虚拟Panel检测数据上进行算法开发，从而提高基因检测Panel产品开发质量和效率。

摘要： 本申请提供用于肺癌检测的靶向测序panel、试剂盒及获得靶向测序panel的方法，靶向测序panel的探针用于分别靶向捕获待捕获样品中的所述102个靶标基因的特定区域，探针根据102个靶标基因设计，102个靶标基因为根据大量基因，基于检测到的SNV以及InDel，计算TXN与SN的皮尔森相关系数RX，选择RX大于0.7得到的102个靶标基因，所述用于肺癌检测的试剂盒能够进行靶向捕获，并根据肺癌预测的打分公式和分类阈值，能够将I和II期肺癌患者与健康人进行准确的区分，其检测可靠性经验证，ROC曲线的AUC值达0.9以上。

摘要： 本申请提供用于肺癌检测的靶向测序panel、试剂盒及获得靶向测序panel的方法，靶向测序panel的探针用于分别靶向捕获待捕获样品中的所述102个靶标基因的特定区域，探针根据102个靶标基因设计，102个靶标基因为根据大量基因，基于检测到的SNV以及InDel，计算TXN与SN的皮尔森相关系数RX，选择RX大于0.7得到的102个靶标基因，所述用于肺癌检测的试剂盒能够进行靶向捕获，并根据肺癌预测的打分公式和分类阈值，能够将I和II期肺癌患者与健康人进行准确的区分，其检测可靠性经验证，ROC曲线的AUC值达0.9以上。

摘要： 本发明提供了一种肺癌围手术期分子残留病灶基因检测panel及检测模型的构建方法，涉及生物信息学技术领域。本发明通过整合肿瘤数据库和TCGA、COSMIC等著名肿瘤公共数据库，设计了一款覆盖肺癌驱动基因、靶向用药基因及热点突变的肺癌MRD基因检测panel，并开发了一套检测超低频基因突变预测模型。本发明以大样本量数据作为基础，聚焦肺癌驱动基因和热点突变，保证检测结果准确性；超高测序深度，保证了超低频检测限，超低频基因突变算法，提高突变检测精准度。本发明实施例证实，所述预测模型可以稳定检测0.02％的超低频突变。

摘要： 本发明公开了一种遗传早发主动脉夹层风险基因筛查panel及筛查方法；针对遗传早发主动脉夹层风险筛查，提出以下8个TGFBR1、TGFBR2、TGFB3、SMAD3、ACTA2、MYH11、MYLK、PRKG1与遗传早发主动脉夹层风险相关基因；通过上述8个突变基因设计panel，利用该panel，结合本发明提供的遗传早发主动脉夹层风险基因筛查方法，对遗传早发性主动脉夹层风险进行筛查检测，经验证，panel中重要位点的覆盖度大于99％，检测准确率达到98％以上，灵敏度大于95％。

摘要： 本发明提供了一种成人胶质瘤分子分型panel，该panel基于二代测序技术设计，针对IDH1、IDH2、CDKN2A、CDKN2B、TERT、EGFR、H3F3A、chr7/chr10、1p/19q、ATRX、TP53、HIST1H3B、HIST1H3C、BRAF等基因的全外显子区域及启动子区域进行检测，制作成本较低、覆盖涉及基因可有效对成人胶质瘤进行分型诊断和预后评估，具有广阔的应用前景。

摘要： 一种基于panel数据的TMB检测方法及其应用，属于生物信息学技术领域。为了解决目前利用大panel对TMB进行统计不准确的问题，本发明提供了一种基于panel数据的TMB检测方法，该方法包括：体细胞检测、假阳性位点过滤，TMB计算，最终得到TMB值，通过以上几个模块能够提高TMB值的准确性及稳定性，为免疫治疗提供依据。

摘要： 本发明属于乳腺癌肿瘤多基因检测领域，公开了一种乳腺癌肿瘤检测的多基因panel、试剂盒及其应用。本发明通过挑选TCGA数据库、METABRIC数据库、MSKCC‑IMPACT数据库、美国乳腺癌560例WGS数据库以及肿瘤医院乳腺研究所数据库中与乳腺癌发生发展及靶向治疗密切相关的基因，利用生物素探针杂交法富集其中108个基因的重要外显子区域与部分内含子区域，并进行高深度测序，从而精准检测其中与乳腺癌有明确临床相关性的基因突变、拷贝数变异等事件，并将该多基因筛选列表做成探针，通过DNA测序针对性地检测高危基因，可以更高效地检测出对诊断、治疗有指导意义的基因突变，对肿瘤患者进行精准分型，对临床的诊断和发现靶向治疗的靶点具有重要指导意义。

摘要： 本发明涉及生物检测领域，具体地，涉及肾上腺高血压的基因检测panel。进一步地，本发明提供了一种肾上腺高血压的基因检测panel，包括该基因检测panel的试剂和装置，以及该基因检测panel的用途。使用上述本发明的基因检测panel，结合生物学和生物信息学的相关手段，可以对潜在的致病性突变进行筛选，从而可以结合临床筛查手段和临床表型提高对原发性醛固酮增多症、库欣综合征(皮质醇增多症)，以及嗜铬细胞瘤和副神经节瘤的诊断的效率，弥补目前临床诊断不足的问题。同时灵敏度高，成本和操作难度低。