摘要：
目的 探讨可乐必妥序贯治疗老年慢性阻塞性肺疾病急性加重(AECOPD)的临床疗效和成本/效果比.方法 将45例老年AECOPD患者随机分为可乐比妥口服序贯治疗组(序贯组)和全程静脉治疗组(对照组),比较两组的临床疗效、细菌清除率、不良反应发生率、住院时间、住院总费用,并对成本/效果进行比较.结果 序贯组和对照组有效率分别为86.4％和87.0％,细菌清除率分别为87.50％和88.23％,与对照组比较差异均无统计学意义(P＞0.05).两组不良反应发生率分别为9％和26％,平均住院时间为(16.8±3.8)天和(19.8±3.5)天、平均住院总费用为(3274.73±909.18)元和(4958.23±1102.18)元,两组比较差异有统计学意义(P＜0.05),两组的成本/效果比分别为37.90和56.99.结论 可乐必妥序贯疗法治疗老年AECOPD疗效确切,安全经济,是治疗AECOPD的优选治疗方案.%Objective To discuss on levofloxacin sequential therapy in Senile acute exacerbations of chronic obstructive pulmonary disease(AECOPD) of clinical efficacy and cost/effectiveness ratio.Methods 45 patients with AECOPD were randomly divided into levofloxacin with oral sequential therapy group(Sequential group) and total intravenous treatment group (control group).Comparison the clinical effects of two groups,the rate of bacterial clearance,the incidence of adverse reactions,duration of hospitalization,the total cost of hospitalization,and cost/effect were compared.Results Sequential group and control group efficiencies were respectively 86.4％ and 87.0％,and bacterial clearance rate were 87.50％ and 88.23％,compared with the control group had no significant difference(P ＞ 0.05).Two groups of adverse reaction rates were 9％ and 26％,the average hospitalization time was (16.8 ± 3.8) and (19.8 ± 3.5) days,the average total cost of hospitalization was (3274.73 ± 909.18) and (4958.23 ± 1102.18) yuan,statistical analysis had significant difference (P ＜ 0.05),two groups of cost/effectiveness ratio were 37.90 and 56.99.Conclusion Levofloxacin sequential therapy in the treatment of senile AECOPD exact curative effect,safety and economy,is the preferred treatment regimens in treatment of AECOPD.
