ASSESSMENT OF MULTIPLE SIGNALING PATHWAY ACTIVITY SCORE IN AIRWAY EPITHELIAL CELLS TO PREDICT AIRWAY EPITHELIAL ABNORMALITY AND AIRWAY CANCER RISK

摘要

The present invention relates to means and methods that can identify subjects, who have abnormal changes in airway epithelium and/or are at increased risk for developing an airway cancer, based on a combination of activities of signaling pathways in an epithelial cell sample derived from an airway of the subject. The signaling pathways comprise two or more signaling pathways selected from the group consisting of a TGF-β pathway, a P13K-FOXO pathway, and a Notch pathway.