METHODS OF PREDICTING AND ENHANCING RESPONSES TO CANCER IMMUNOTHERAPY BASED ON HUMAN GUT MICROBIOME AND METHODS OF SCREENING PREBIOTICS CANDIDATES

摘要

In the present specification, for feces isolated from patients, according to the GTDB phylogenetic classification, TANB77 order, taxa belonging to the TANB77 order (taxa), according to the GTDB phylogenetic classification, CAG-269 sp000431335 species, CAG- 465 sp000433135 species, CAG-465 sp000433335 species, CAG-269 sp001916055 species, CAG-465 sp000433755 species, CAG-793 sp000433915 species, CAG-492 sp000434015 species, CAG-452 sp000434035 species, CAG-245 sp000434195 species, CAG-492 sp000434335 species species, CAG-245 sp000435175 species, CAG-273 sp003507395 species, CAG-269 sp000435535 species, CAG-273 sp000435755 species, CAG-269 sp001916065 species, CAG-269 sp000437215 species, CAG-354 sp001915925 species, CAG-273 sp000437855 species, CAG-269 sp003525075 sp., CAG-269 sp000438255 sp., CAG-273 sp000438355 sp., CAG-269 sp001915995 sp., CAG-269 sp001916005 sp., CAG-269 sp001916035 sp., UBA1234 sp002308995 sp., CAG-452 sp002314935 sp., CAG-269 sp0023729 Species, CAG-793 sp002393975 sp., UBA1234 sp002404755 sp., UBA7001 sp002449785 sp., CAG-492 sp002633185 sp., CAG-269 sp003518755 sp., CAG-273 sp003534295 sp., CAG-269 sp., CAG-492 sp., CAG-793 sp., CAG -452, CAG-245, CAG-273, CAG-354, UBA7001, CAG-465, UBA1234, CAG-508, CAG- assessing the enrichment of at least one strain of the 465 family and the UBA1234 family, and based on the enrichment of the strain according to the TANB77 order, or the taxa or at least one GTDB phylogenetic classification, immunity to the patient. A method for predicting a therapeutic response of an immune anticancer therapy comprising the step of predicting a therapeutic response to an anticancer therapy, a probiotic composition comprising the at least one strain for enhancing the therapeutic response, the TANB77 order, or the taxa or the above A composition for transplanting a fecal microbiome comprising at least one strain and a method for screening candidate prebiotics using the same are provided.