TUMOR-TARGETING NANODRUG SIMULTANEOUSLY ENCLOSING PHOTOSENSITIZER AND PROTEIN, AND USE THEREOF

摘要

A tumor-targeting nanodrug simultaneously enclosing a photosensitizer and a protein and the use thereof in the preparation of anti-tumor drugs. The tumor-targeting nanodrug is prepared by means of using a metal organic framework to enclose a hydrophobic photosensitizer and a protein drug, and then modifying same with a modifier. The tumor-targeting nanodrug has the characteristics of active targeting of tumor cells and drug release in response to a tumor microenvironment, and the synergistic treatment of photodynamic therapy and protein therapy along with fluorescence imaging can be realized, thereby achieving good diagnosis and treatment effects.