A system 100 for simulation training of extra corporeal life support therapies such as ECMO and ECPR is disclosed. The system comprises a patient mannequin 212 with torso and head and a plurality of sensors 201-203 configured for sensing pre-determined parameters during the simulation training scenarios. An internal tank reservoir 101 is provided for seamless air free circulation of fluid, an external perfusion simulator 102 configured to fill fluid into the internal tank reservoir 101, a plurality of fluid pumps 104,111 configured to prime the system and create pulsations during simulation of various clinical scenarios. A plurality of silicone mixture moulds embedded on or inside the torso provide for realistic ultrasound guided vessel cannulation.
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