ORGANIC ARSENIC-BASED TYPE II PYRUVATE KINASE INHIBITOR AS WELL AS PREPARATION METHOD THEREFOR AND USE THEREOF

摘要

Provided by the present invention are an organic arsenic-based type II pyruvate kinase inhibitor as well as a preparation method therefor and a use thereof. Specifically, a PKM2 inhibitor of the present invention is a compound represented by formula I, or a pharmaceutically acceptable salt thereof, or a stereoisomer or tautomer, a hydrate or a solvate thereof, wherein, X1, X2, R1, R2, R3, R4, R5 and n are as defined in the description. The compound of the present invention has a high inhibitory activity and high specificity for PKM2 and is well suited for the preparation of a drug inhibiting tumors by inhibiting a PKM2 pathway.