MAGNETIC MICROPARTICLE CHEMILUMINESCENCE REAGENT KIT FOR DETECTING SARS-COV-2 VIRUS NEUTRALISING ANTIBODIES AND APPLICATION THEREFOR

摘要

A magnetic microparticle chemiluminescence reagent kit for detecting SARS-CoV-2 virus neutralising antibodies and an application therefor. The reagent kit comprises the spike protein part of the novel coronavirus and an ACE2 protein or a functional fragment thereof that specifically binds to the spike protein part of the novel coronavirus; the spike protein part of the novel coronavirus connects to a marker, and the ACE2 protein or functional fragment thereof connects to a magnetic microparticle; or the spike protein part of the novel coronavirus connects to a magnetic microparticle, and the ACE2 protein or functional fragment thereof connects to a marker. The magnetic microparticle chemiluminescence reagent kit can be used for screening and identifying neutralising antibodies in a biological sample, evaluating the effectiveness of a vaccine, and implementing qualitative or quantitative testing of SARS-CoV-2 virus neutralising antibodies in the sample of a subject.