Optimally activated dendritic cells that induce improved or increased antitumor immune responses

摘要

The present disclosure provides a cell population comprising partially mature and optimally activated dendritic cells that can be used for administration to individuals with cancer and / or tumors. Partially matured dendritic cells (dendritic cells that have been in contact with the dendritic cell maturation agent for about 10 to about 19 hours) efficiently take up tumor antigens in the region of the tumor site upon administration and It can be processed, matured and then moved to the lymph nodes of the individual being treated. Once in the lymph node, now fully mature antigen-presenting dendritic cells secrete appropriate cytokines (eg, TNFα, IL-6, IL-8, and / or IL-12) and T Contacting cells induces a substantial and optimal clinical and / or anti-tumor immune response.