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Folic acid-conjugated aminoclay based nanocomposites for the site-specific drug delivery, method for their preparation and their use
Folic acid-conjugated aminoclay based nanocomposites for the site-specific drug delivery, method for their preparation and their use
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机译:基于叶酸 - 缀合的氨基粘土基于特异性药物递送的纳米复合材料,其制备方法及其使用
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摘要
The present invention relates to a target selective nanocomposite based on folate-conjugated aminoclay (FA-AC), a method for preparing the same, and a use thereof. In the present invention, the target selectivity is increased by binding folic acid-conjugated aminoclay with a drug to form a nanocomposite, and furthermore, the stability of the loaded drug in the gastrointestinal tract is improved by surface coating the nanocomposite with a pH-sensitive polymer. The therapeutic effect can be significantly improved. Since the nanocomposite of the present invention targets the folate receptor, it can be applied as an effective drug delivery system for the prevention and treatment of inflammatory diseases or cancer in which the folate receptor is overexpressed.
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