USE OF SERRULATAN DITERPENES IN MEDICINE

摘要

FIELD: medicine.;SUBSTANCE: invention relates to a method for the treatment of cancer, where the method includes the injection of therapeutically effective amount of a compound of the formula (I); ;(I),;its pharmaceutically acceptable salt or solvate, or a pharmaceutical composition including the specified compounds to a subject who needs it. In the formula (I): X is CH2; R1 is OH, OC1-5alkyl or OC(O)C1-5alkyl; R2 is OH, OC1-5alkyl or OC(O)C1-5alkyl; R3 is H; R4 is OH, OC1-5alkyl or OC(O)C1-5alkyl; and A---B is CH=C or CH2-CH. A compound of the formula (I), its use for the treatment of cancer and skin disease or disorder, and a pharmaceutical composition including the compound of the formula (I) are also proposed.;EFFECT: invention allows for producing serrulatan diterpenes of the formula (I) that can be used in the treatment of cancer and skin disease or disorder.;36 cl, 19 dwg, 52 tbl