Acrii ligand trap β－ Treatment of thalassemia

摘要

Subject β- Provide a pharmaceutical composition for use in the therapy of thalassemia.Activator receptor type II (actii) signal transduction inhibitorβ- Subject of treatment of thalassemia β- Medicinal composition for use in the treatment of thalassemia;Said method: (a) administering said acrii signal inhibitor to an object at an initial dose of about 0.8 mg / kg or about 1.0 mg / kg;Obtaining the first measurement value of the fetal hemoglobin concentration of said subject;(c) after the first period after step (b)Acquiring a second measurement of the fetal hemoglobin concentration of said subject;And (d) after the second periodAdministering the actri signal inhibitor to the subject at a subsequent dose;IncludingThe above described pharmaceutical composition.Diagram