Methods for making glucagon-like peptide-1 (GLP-1) receptor agonists and analogs thereof

摘要

The present invention relates to methods for preparing glucagon-like peptide-1 (glp-1) receptor agonists and analogs thereof. The present invention further relates to methods for preparing liraglutide, D-liraglutide, semaglutide and D-semaglutide. The present invention specifically relates to methods for preparing glucagon-like peptide-1 (glp-1) agonists and analogs thereof, wherein the liraglutide, D-liraglutide, semaglutide and D- Semagglutide is substantially pure. The present invention also relates to the preparation of glucagon-like peptide-1 (glp-1) agonists and analogs thereof by solid and solution phase methods.