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CD44 Targeted Multi-Arm Conjugate

机译:CD44靶向多臂缀合物

摘要

A class of multi-branched drug conjugates capable of specifically targeting CD44 are disclosed. This class of compounds binds specifically to CD44 and can target tumor cells and tissues with high CD44 expression, thereby resulting in a high concentration of the conjugate in the target tissue, improving its clinical therapeutic effect, and reducing toxicity. decreases. The compounds of the present invention include, but are not limited to, gastric cancer, pancreatic cancer, small cell lung cancer, colon cancer, breast cancer, lung adenocarcinoma, liver cancer, nasopharyngeal carcinoma, malignant glioma, lymphoma, renal carcinoma, ovarian cancer, head and neck cancer, squamous cell carcinoma, and the like. It is suitable for treating all tumors with high CD44 expression.
机译:公开了一类能够特异性靶向CD44的多分支药物缀合物。 这类化合物特异性地结合CD44,可以靶向具有高CD44表达的肿瘤细胞和组织,从而导致靶组织中的高浓度的缀合物,提高其临床治疗效果,降低毒性。 减少。 本发明的化合物包括但不限于胃癌,胰腺癌,小细胞肺癌,结肠癌,乳腺癌,肺腺癌,肝癌,鼻咽癌,恶性胶质瘤,淋巴瘤,肾癌,卵巢癌 ,头颈癌,鳞状细胞癌等。 它适用于用高CD44表达治疗所有肿瘤。

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