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OLIGONUCLEOTIDE PROBE FOR DETECTING SINGLE NUCLEOTIDE POLYMORPHISMS, AND METHOD FOR DETERMINING CIS-TRANS CONFIGURATION
OLIGONUCLEOTIDE PROBE FOR DETECTING SINGLE NUCLEOTIDE POLYMORPHISMS, AND METHOD FOR DETERMINING CIS-TRANS CONFIGURATION
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机译:用于检测单一核苷酸多态性的寡核苷酸探针,以及确定顺式 - 反式配置的方法
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摘要
A probe comprising a reporter region for detecting a first single nucleotide polymorphism, an anchor region for detecting a second single nucleotide polymorphism, and a linker region is disclosed. The reporter region comprises an oligonucleotide consisting of a sequence perfectly matching with the first target sequence, and a fluorescent dye that quenches when hybridized to the first target sequence where the first single nucleotide polymorphism is present. The anchor region comprises an oligonucleotide consisting of a sequence perfectly matching with a second target sequence where the second single nucleotide polymorphism is present. A length of the oligonucleotide of the reporter region is shorter than a length of the oligonucleotide of the anchor region.
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