An assay to determine the possibility of protein self association using concentration dependent self interacting nanoparticle spectroscopy

摘要

Provided is a method for producing a highly stable high concentration protein preparation. Early in the manufacturing process, an assay is used to select proteins and formulation conditions with high self-repulsive properties. Specifically, protein concentration-dependent self-interaction nanoparticle spectroscopy is used as a protein colloid interaction assay. [Selection figure] None