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REPROGRAMMING THE METABOLOME TO DELAY ONSET OR TREAT NEURODEGENERATION
REPROGRAMMING THE METABOLOME TO DELAY ONSET OR TREAT NEURODEGENERATION
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机译:重新编程代谢物以延迟发作或治疗神经变性
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摘要
The present disclosure relates to methods and compounds for reprogramming metabolism in one specific retinal and neuronal cell type leading to improved cell and tissue survival and function. In particular, the present disclosure relates to increasing PGC1α/Pgclα or NRF2/Nrf2 or inhibiting HIF/Hif or KEAP1/Keap1 to reprogram metabolism and survival of cells in a variety of neurodegenerative conditions, and specifically those which cause blindness.
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