METHOD AND SYSTEM FOR DIAGNOSIS AND MANAGEMENT OF GASTROESOPHAGEAL DISEASES

摘要

Methods and systems for the diagnosis, treatment, and management of gastroesophageal diseases including gastroesophageal reflux disease, reflux laryngitis, nonerosive reflux disease and gastric cancer using saliva based biomarkers are presented herein. The biomarkers may include E-cadherin, TGF-α, EGF, IL-6, pepsin, MOB kinase activator 1A, EphA1, MOB kinase Activator 1B, integrin alpha 5, Golgi resident protein GCP 60, FR‐beta, protein SEC13 homolog, epiregulin, FGF‐12, inhibitor of nuclear factor kappa B kinase catalytic subunit, vimentin, annexin A1, protein S100-A6, malate dehydrogenase, proteasome activator complex subunit 2, cathepsin D light chain, MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, mucin-1, alpha-1-acid glycoprotein, antithrombin, serpin peptidase inhibitor, CTSF, HMGB1, TLR7, COPS2, NT5E, TERF1, TIMP-1, TIMP-2, TIMP-4, XPNPEP2, TGFR2, SIGLEC6, CPE, GHR, GPNMB, SLAMF8, TNFRSF19, TWEAK, IFNGR1, Notch-3, TNFRSF19L, annexin A6, α-defensin-1, caveolin 1, EGF receptor, integrin beta 4, S100A6, S100A8, S100A9, and/or haptoglobin.