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Compstatin Analogs with Increased Solubility and Improved Pharmacokinetic Properties
Compstatin Analogs with Increased Solubility and Improved Pharmacokinetic Properties
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机译:Compstatin类似物的溶解度增加和改善的药代动力学性质
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摘要
Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. The compounds comprise compstatin analogs in which the N-terminus and/or C-terminus contains an added component that improves (1) the peptide's solubility at physiological pH; (2) the peptide's plasma half-life; (3) the peptide's intraocular retention; and/or (4) the peptide's binding affinity to C3 or its fragments as compared to an unmodified compstatin peptide under equivalent conditions. Pharmaceutical compositions and methods of using the compounds are also disclosed.
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