A system 100 for simulation training of extra corporeal life support therapies, wherein the system 100 comprises a patient mannequin 212 with torso and head, a plurality of sensors 201-203 configured for sensing pre-determined parameters during the simulation training scenarios, an internal tank reservoir 101 configured to act like a fluid reservoir to help in seamless air free circulation of fluid for simulation, an external perfusion simulator 102 configured to fill fluid into the internal tank reservoir 101, a plurality of fluid pumps 104,111 configured to prime the system and create pulsations during simulation of various clinical scenarios, a plurality of electrically controlled solenoid valves 103,110 configured to direct the fluid flow and create resistance, a plurality of silicone mixture molds embedded on or inside the torso to perform realistic ultrasound guided vessel cannulation and a plurality of connectors 124,125 to connect the internal tank reservoir 101 to the external perfusion simulator 102.
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