MICRORNA-7 COMPOSITIONS FOR PROMOTING FUNCTIONAL RECOVERY FOLLOWING SPINAL CORD INJURY AND METHODS OF USE THEREOF

摘要

Compositions, recombinant viral vectors, recombinant viruses, and nanoparticles for treating a subject having a spinal cord injury include a therapeutically effective amount of a nucleic acid sequence encoding pre-microRNA-7 (pre-miR-7). Methods of using these compositions, recombinant viral vectors, recombinant viruses, and nanoparticles are also described herein. These compositions, recombinant viral vectors, recombinant viruses, and nanoparticles and methods of use provide novel therapies for SCI based on the discovery that miR-7 expression provides neuroprotection and recovery of locomotor function in subjects having SCI.