UV A METHOD FOR MANUFACTURING GEL-TYPE SYNTHETIC BONE GRAFT MATERIAL USING UV CROSS-LINKING

摘要

The present invention relates to a method for producing a gel-type synthetic bone graft material using UV cross-linking, and more particularly, to a method for producing a gel-type synthetic bone graft material using UV cross-linking, (1) Synthesis using a spray drying method preparing the bone graft material particles in a spherical shape; (2) preparing a granular synthetic bone graft material by mixing and compressing the synthetic bone graft material particles prepared in the spherical shape in step (1) with PMMA (polymethyl methacrylate) and a binder, and heat-treating them; and (2) mixing the granular synthetic bone graft material prepared in step (2) with the collagen solution, and performing UV crosslinking in a liquid state to prepare a gel-type synthetic bone graft material. characterized. According to the method for producing a gel-type synthetic bone graft material using UV crosslinking proposed in the present invention, the synthetic bone graft material particles are prepared in a spherical shape using a spray-drying method, and the synthetic bone graft material particles prepared in the spherical shape are mixed with PMMA (polymethyl metabolite). acrylate) and a binder are mixed and compressed, heat treated to prepare a granular synthetic bone graft material, then a collagen solution is mixed, and UV cross-linking is performed in a liquid state to produce a gel-type synthetic bone graft material. It is possible to ensure that the formability and viscosity of the bone graft material manufactured with this type of synthetic bone graft material is excellent, but there is no possibility of inducing toxicity. In addition, according to the method for producing a gel-type synthetic bone graft material using UV cross-linking of the present invention, the inconvenience of operation, which is a disadvantage of conventional powder-type bone graft materials, is minimized, and a gel-type synthetic bone graft material is manufactured through UV cross-linking of collagen. By doing so, the convenience of use of the procedure can be improved because it is stable and morphological can be manipulated when used in implant procedures, and the physical cross-linking using UV rather than chemical cross-linking using EDC of collagen increases the stability of collagen without toxicity caused by EDC. Even with a small amount of expensive collagen, the viscosity of the synthetic bone graft material can be secured.