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Virus Inactivation Method for Continuous Production of Antibodies
Virus Inactivation Method for Continuous Production of Antibodies
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机译:抗体连续生产的病毒失活方法
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摘要
The present disclosure relates to methods for use in inactivating viruses. The virus inactivation method is for use in the continuous process preparation of a biologic, such as an antibody, comprising separating an eluate using a column and subjecting the eluate simultaneously to orthogonal treatment of low pH and detergent, wherein The time for virus inactivation is reduced. In addition, the detergent can be added to the buffer system of the purification process to achieve the same effect. The biologic in each treatment case is maintained.
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