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A METHOD FOR PRODUCTION OF HIGH PURITY ICATIBANT
A METHOD FOR PRODUCTION OF HIGH PURITY ICATIBANT
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机译:一种生产高纯度释放的方法
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摘要
The present invention provides a process for the manufacture of peptidomimetic drug icatibant with high yield and purity by fragment condensation on the solid phase. In particular, it describes a convergent synthesis by condensation of a protected C-terminal fragment bound to a solid support and a protected N-terminal fragment, followed by cleavage from the support and resulting in a crude peptide of high purity, which is further purified to obtain pure icatibant in high yield. The invention further provides intermediates useful in the manufacturing process.
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